Variability of Clostridium difficile surface proteins and specific serum antibody response in patients with Clostridium difficile-associated disease

Journal of Clinical Microbiology

Volumn 43, Issue 10, 2005, Pages 5018-5025

  Péchiné, Séverine ^a   Janoir, Claire ^a   Collignon, Anne ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; CELL MEMBRANE PROTEIN; CELL PROTEIN; FLAGELLIN; PROTEIN CWP66; PROTEIN FLIC; PROTEIN FLID; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ARTICLE; BACTERIAL INFECTION; BACTERIUM ISOLATION; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CLOSTRIDIUM DIFFICILE; CONTROLLED STUDY; CWP66 GENE; CWP84 GENE; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GENE AMPLIFICATION; IMMUNOBLOTTING; IMMUNOGENICITY; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; VACCINE PRODUCTION;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY SPECIFICITY; BACTERIAL PROTEINS; CLOSTRIDIUM DIFFICILE; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FLAGELLIN; GENOTYPE; HUMANS; MEMBRANE PROTEINS; MICE; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RIBOTYPING; SENSITIVITY AND SPECIFICITY; VARIATION (GENETICS);

ANIMALIA; BACTERIA (MICROORGANISMS); CLOSTRIDIUM DIFFICILE;

EID: 26944469989     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.43.10.5018-5025.2005     Document Type: Article

References (29)

1. Aboudola, S., K. L. Kotloff, M. Warny, E. C. Kelly, S. Sougioultzis, P. J. Giannasca, T. P. Monath, and C. P. Kelly. 2003. Clostridium difficile vaccine and serum immunoglobulin G antibody response to toxin A. Infect. Immun. 71:1608-1610.
2. Beachey, E. H. 1981. Bacterial adherence: adhesion-receptor interactions mediating the attachment of bacteria to mucosal surfaces. J. Infect. Dis. 143:325-345.
3. Bidet, P., V. Lalande, B. Salauze, B. Burghoffer, V. Avesani, M. Delmee, A. Ros, F. Barbut, and J.-C. Petit. 2000. Comparison of PCR-ribotyping, arbitrarily primed PCR, and pulsed-field gel electrophoresis for typing Clostridium difficile. J. Clin. Microbiol. 38:2484-2487.
4. Calabi, E., and N. Fairweather. 2002. Patterns of sequence conservation in the S-layer proteins and related sequences in Clostridium difficile. J. Bacteriol. 184:3886-3897.
5. Cerquetti, M., A. Serafino, A. Sebastianelli, and P. Mastrantonio. 2002. Binding of Clostridium difficile to Caco-2 epithelial cell line and to extracellular matrix proteins. FEMS Immunol. Med. Microbiol. 32:211-218.
6. Delmée, M., V. Avesani, N. Delferriere, and G. Burtonboy. 1990. Characterization of flagella of Clostridium difficile and their role in serogrouping reactions. J. Clin. Microbiol. 28:2210-2214.
7. Drudy, D., E. Calabi, L. Kyne, S. Sougioultzis, E. Kelly, N. Fairweather, and C. P. Kelly. 2004. Human antibody response to surface layer proteins in Clostridium difficile infection. FEMS Immunol. Med. Microbiol. 41:237-242.
8. Guzman, C. A., S. R. Talay, G. Molinary, E. Medina, and G. S. Chhatwal. 1999. Protective immune response against Streptococcus pyogenes in mice after intranasal vaccination with the fibronectin-binding protein SfbI. J. Infect. Dis. 179:901-906.
9. Hoepelman, A. I. M., and E. I. Tuomanen. 1992. Consequences of microbial attachment: directing host cell functions with adhesins. Infect. Immun. 60: 1729-1733.
10. Isberg, R. R., and G. Tran Van Nhieu. 1994. Binding and internalization of microorganisms by integrin receptors. Trends Microbiol. 2:10-14.
11. Janoir, C., J. Grénery, M.-P. Savariau-Lacomme, and A. Collignon. 2004. Caractérisation d'une protéase extracellulaire de Clostridium difficile. Pathol. Biol. 52:444-449.
12. Know, H.-Y., A. D. Ogunniyi, M.-H. Choi, S.-N. Pyo, D.-K. Rhee, and J. C. Paton. 2004. The ClpP protease of Streptococcus pneumoniae modulates virulence gene expression and protects against fatal pneumococcal challenge. Infect. Immun. 72:5646-5653.
13. Kyne, L., M. Warny, A. Qamar, and C. P. Kelly. 2001. Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea. Lancet 357:189-193.
14. McCoubrey, J., and I. R. Poxton. 2001. Variation in the surface layer proteins of Clostridium difficile. FEMS Immunol. Med. Microbiol. 31:131-135.
15. Mulligan, M. E., S. D. Miller, L. V. McFarland, H. C. Fung, and R. Y. Y. Kwok. 1993. Elevated levels of serum immunoglobulins in asymptomatic carriers of Clostridium difficile. Clin. Infect. Dis. 16:S239-S244.
16. Nusrat, A., C. von Eichel-Streiber, J. R. Turner, P. Verkade, J. L. Madara, and C. A. Parkos. 2001. Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins. Infect. Immun. 69:1329-1336.
17. Pechine, S., A. Gleizes, C. Janoir, R. Gorges-Kergot, M.-C. Barc, M. Delmée, and A. Collignon. 2005. Immunological properties of surface proteins of Clostridium difficile. J. Med. Microbiol. 54:193-196.
18. Pothoulakis, C. 1996. Pathogenesis of Clostridium difficile-associated diarrhoea. Eur. J. Gastroenterol. Hepatol. 8:1041-1047.
19. Ramos, H. C., M. Rumbo, and J.-C. Sirard. 2004. Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa. Trends Microbiol. 12:509-517.
20. Rostand, K. S., and J. D. Esko. 1997. Microbial adherence and invasion through proteoglycans. Infect. Immun. 65:1-8.
21. Savariau-Lacomme, M.-P., C. Lebarbier, T. Karjalainen, A. Collignon, and C. Janoir. 2003. Transcription and analysis of polymorphism in a cluster of genes encoding surface-associated proteins of Chstndium difficile. J. Bacteriol. 185:4461-4470.
22. Strindelius, L., M. Filler, and I. Sjöholm. 2004. Mucosal immunization with purified flagellin from Salmonella induces systemic and mucosal immune responses in C3H/HeJ mice. Vaccine 22:3797-3808.
23. Tasteyre, A., M.-C. Barc, T. Karjalainen, P. Dodson, S. Hyde, P. Bourlioux, and P. Borriello. 2000. A Clostridium difficile gene encoding flagellin. Microbiology 146:957-966.
24. Tasteyre, A., T. Karjalainen, V. Avesani, M. Delmée, A. Collignon, P. Bourlioux, and M.-C. Barc. 2000. Phenotypic and genotypic diversity of the flagellin gene (fliC) among Clostridium difficile isolates from different serogroups. J. Clin. Microbiol. 38:3179-3186.
25. Tasteyre, A., T. Karjalainen, V. Avesani, M. Delmée, A. Collignon, P. Bourlioux, and M.-C. Barc. 2001. Molecular characterization of fliD gene encoding flagellar cap and its expression among Clostridium difficile isolates from different serogroups. J. Clin. Microbiol. 39:1178-1183.
26. Waligora, A.-J., C. Hennequin, P. Mullany, P. Bourlioux, A. Collignon, and T. Karjalainen. 2001. Characterization of a cell surface protein of Clostridium difficile with adhesive properties. Infect. Immun. 69:2144-2153.
27. Wexler, H., M. E. Mulligan, and S. M. Finegold. 1984. Polyacrylamide gel electrophoresis patterns produced by Clostridium difficile. Rev. Infect. Dis. 6(Suppl):S229-S234.
28. Winstandley, C., and J. A. Morgan. 1997. The bacterial flagellin gene as a biomarker for detection, population genetics and epidemiological analysis. Microbiology 143:3071-3084.
29. Zhou, X., J. A. Giron, A. G. Torres, J. A. Crawford, E. Negrete, S. N. Vogel, and J. B. Kaper. 2003. Flagellin of enteropathogenic Escherichia coli stimulates interleukin-8 production in T84 cells. Infect. Imnnun. 71:2120-2129.