GWAS-identified loci for coronary heart disease are associated with intima-media thickness and plaque presence at the carotid artery bulb

Atherosclerosis

Volumn 239, Issue 2, 2015, Pages 304-310

  Den Hoed, Marcel ^a   Strawbridge, Rona J ^b   Almgren, Peter ^c   Gustafsson, Stefan ^a   Axelsson, Tomas ^a   Engström, Gunnar ^c   de Faire, Ulf ^d   Hedblad, Bo ^c   Humphries, Steve E ^e   Lindgren, Cecilia M ^f   Morris, Andrew P ^f,g   Östling, Gerd ^c   Syvänen, Ann Christine ^a   Tremoli, Elena ^h   Hamsten, Anders ^b   Ingelsson, Erik ^a   Melander, Olle ^c   Lind, Lars ⁱ  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g UNIVERSITY OF LIVERPOOL   (United Kingdom)

^h UNIVERSITY OF MILAN   (Italy)

ⁱ UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Atherogenic plaque; Atherosclerosis; Carotid artery; Genome wide association; Intima media thickness

Indexed keywords

ADAMTS7 PROTEIN; APOLIPOPROTEIN; KCNK5 PROTEIN; LPA PROTEIN; LPAL2 PROTEIN; METALLOPROTEINASE; MRAS PROTEIN; PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROTIC PLAQUE; B SCAN; CAROTID ATHEROSCLEROSIS; CHROMOSOME 19; CHROMOSOME 9P; COMMON CAROTID ARTERY; CONTROLLED STUDY; EUROPEAN; FEMALE; FRAMINGHAM RISK SCORE; GENE CLUSTER; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC PREDISPOSITION; GENETIC RISK; GENOTYPE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PREVALENCE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; CORONARY ARTERY DISEASE; EUROPE; GENETICS; META ANALYSIS; ODDS RATIO; PATHOLOGY; RISK FACTOR;

AGED; ALLELES; CAROTID ARTERY, COMMON; CAROTID INTIMA-MEDIA THICKNESS; CORONARY DISEASE; EUROPE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; PLAQUE, ATHEROSCLEROTIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84922537514     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2015.01.032     Document Type: Article

References (32)

1. Kannel W.B. Some lessons in cardiovascular epidemiology from Framingham. Am. J. Cardiol. 1976, 37:269-282.
2. Peden J.F., et al. Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour. Hum. Mol. Genet. 2011, 20:R198-R205.
3. Ozaki K., et al. Genome-wide association study to identify single-nucleotide polymorphisms conferring risk of myocardial infarction. Methods Mol. Med. 2006, 128:173-180.
4. The CARDIoGRAMplusC4D Consortium, et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat. Genet. 2012, 45:25-33.
5. Lorenz M.W., et al. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 2007, 115:459-467.
6. O'Leary D.H., et al. Thickening of the carotid wall. A marker for atherosclerosis in the elderly? Cardiovascular Health Study Collaborative Research Group. Stroke 1996, 27:224-231.
7. Rosvall M., et al. Incident coronary events and case fatality in relation to common carotid intima-media thickness. J.Intern. Med. 2005, 257:430-437.
8. Rosvall M., et al. Incidence of stroke is related to carotid IMT even in the absence of plaque. Atherosclerosis 2005, 179:325-331.
9. Amato M., et al. Carotid intima-media thickness by B-mode ultrasound as surrogate of coronary atherosclerosis: correlation with quantitative coronary angiography and coronary intravascular ultrasound findings. Eur. Heart J. 2007, 28:2094-2101.
10. Graner M., et al. Association of carotid intima-media thickness with angiographic severity and extent of coronary artery disease. Am. J. Cardiol. 2006, 97:624-629.
11. Hansen T., et al. Atotal atherosclerotic score for whole-body MRA and its relation to traditional cardiovascular risk factors. Eur. Radiol. 2008, 18:1174-1180.
12. Kablak-Ziembicka A., et al. Diagnostic value of carotid intima-media thickness in indicating multi-level atherosclerosis. Atherosclerosis 2007, 193:395-400.
13. Hamrefors V., et al. Amyocardial infarction genetic risk score is associated with markers of carotid atherosclerosis. J.Intern. Med. 2012, 271:271-281.
14. Baldassarre D., et al. Measurements of carotid intima-media thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events: results of the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. J.Am. Coll. Cardiol. 2012, 60:1489-1499.
15. Magnusson M., et al. Adiabetes-predictive amino acid score and future cardiovascular disease. Eur. Heart J. 2013, 34:1982-1989.
16. Wohlin M., et al. Apolipoprotein E epsilon4 genotype is independently associated with increased intima-media thickness in a recessive pattern. Lipids 2007, 42:451-456.
17. Andersson J., et al. Echogenecity of the carotid intima-media complex is related to cardiovascular risk factors, dyslipidemia, oxidative stress and inflammation: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Atherosclerosis 2009, 204:612-618.
18. The 1000 Genomes Project Consortium, et al. An integrated map of genetic variation from 1,092 human genomes. Nature 2012, 491:56-65.
19. Burgess S., et al. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet. Epidemiol. 2013, 37:658-665.
20. Bis J.C., et al. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat. Genet. 2011, 43:940-947.
21. Purcell S., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 2007, 81:559-575.
22. Marchini J., et al. Anew multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet. 2007, 39:906-913.
23. Willer C.J., et al. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 2010, 26:2190-2191.
24. Gauderman W.J., Morrison J.M. QUANTO 1.1: a Computed Program for Power and Sample Size Calculations for Genetic-epidemiology Studies 2006, http://hydrauscedu/gxe.
25. Ebrahim S., et al. Carotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: the British Regional Heart Study. Stroke 1999, 30:841-850.
26. Dudbridge F. Power and predictive accuracy of polygenic risk scores. PLoS Genet. 2013, 9:e1003348.
27. Helgadottir A., et al. Acommon variant on chromosome 9p21 affects the risk of myocardial infarction. Sci. (New York, N. Y.) 2007, 316:1491-1493.
28. McPherson R., et al. Acommon allele on chromosome 9 associated with coronary heart disease. Sci. (New York, N. Y.) 2007, 316:1488-1491.
29. Samani N.J., et al. Genomewide association analysis of coronary artery disease. N.Engl. J. Med. 2007, 357:443-453.
30. Holdt L.M., et al. Recent studies of the human chromosome 9p21 locus, which is associated with atherosclerosis in human populations. Arterioscler. Thromb. Vasc. Biol. 2012, 32:196-206.
31. Congrains A., et al. Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B. Atherosclerosis 2012, 220:449-455.
32. Palomaki G.E., et al. Association between 9p21 genomic markers and heart disease: a meta-analysis. JAMA 2010, 303:648-656.