Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

Nature Genetics

Volumn 43, Issue 10, 2011, Pages 940-948

  Bis, Joshua C ^a   Kavousi, Maryam ^b,c   Franceschini, Nora ^d   Isaacs, Aaron ^b,e   Abecasis, Gonçalo R ^f   Schminke, Ulf ^g   Post, Wendy S ^h   Smith, Albert V ⁱ   Cupples, L Adrienne ^j,k   Markus, Hugh S ^l   Schmidt, Reinhold ^m   Huffman, Jennifer E ⁿ   Lehtimäki, Terho ^o,p   Baumert, Jens ^q   Münzel, Thomas ^r   Heckbert, Susan R ^a,s   Dehghan, Abbas ^b,c   North, Kari ^t   Oostra, Ben ^b,e   Bevan, Steve ^l   Stoegerer, Eva Maria ^m   Hayward, Caroline ⁿ   Raitakari, Olli ^u,v   Meisinger, Christa ^q   Schillert, Arne ^w   Sanna, Serena ^x   Völzke, Henry ^g   Cheng, Yu Ching ^y   Thorsson, Bolli ⁱ   Fox, Caroline S ^k,z   Rice, Kenneth ^aa   Rivadeneira, Fernando ^b,c   Nambi, Vijay ^ab,ac,ad   Halperin, Eran ^ae,af   Petrovic, Katja E ^m   Peltonen, Leena ^ag,ah   Wichmann, H Erich ^q   Schnabel, Renate B ^r   Dörr, Marcus ^g   Parsa, Afshin ^y   Aspelund, Thor ^i,ai   Demissie, Serkalem ^j   Kathiresan, Sekar ^aj,ak   Reilly, Muredach P ^al   Taylor, Kent ^am   Uitterlinden, Andre ^b,c   Couper, David J ^d   Sitzer, Matthias ^an   Kähönen, Mika ^o,p   Illig, Thomas ^q,ao   Wild, Philipp S ^r   Orru, Marco ^x,ap   Lüdemann, Jan ^g   Shuldiner, Alan R ^y,aq   Eiriksdottir, Gudny ⁱ   White, Charles C ^j   Rotter, Jerome I ^am   Hofman, Albert ^b,c   Seissler, Jochen ^ar   Zeller, Tanja ^r   Usala, Gianluca ^x   Ernst, Florian ^g   Launer, Lenore J ^as   D'Agostino Sr , Ralph B ^at   O'Leary, Daniel H ^au   Ballantyne, Christie ^ab   Thiery, Joachim ^av,aw   Ziegler, Andreas ^w   Lakatta, Edward G ^ax   Chilukoti, Ravi Kumar ^g   Harris, Tamara B ^as   Wolf, Philip A ^k,ay   Psaty, Bruce M ^a,s,aa   Polak, Joseph F ^au   Li, Xia ^d   Rathmann, Wolfgang ^az   Uda, Manuela ^x   Boerwinkle, Eric ^ba   Klopp, Norman ^q   Schmidt, Helena ^m   Wilson, James F ^bb   Viikari, Jorma ^v,bc   Koenig, Wolfgang ^bd   Blankenberg, Stefan ^r   Newman, Anne B ^be   Witteman, Jacqueline ^b,c   Heiss, Gerardo ^d   Duijn, Cornelia Van ^b,c,e   Scuteri, Angelo ^ax   Homuth, Georg ^g   Mitchell, Braxton D ^y   Gudnason, Vilmundur ^i,ai   O'Donnell, Christopher J ^k,aj   more..

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c Netherlands Genomics Initiative   (Netherlands)

^d IL   (United States)

^e LEIDEN UNIVERSITY   (Netherlands)

^f UNIVERSITY OF MICHIGAN   (United States)

^g UNIVERSITY OF GREIFSWALD   (Germany)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ ICELANDIC HEART ASSOCIATION   (Iceland)

^j BOSTON UNIVERSITY   (United States)

^k FRAMINGHAM HEART STUDY   (United States)

^l ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^m MEDICAL UNIVERSITY OF GRAZ   (Austria)

ⁿ WESTERN GENERAL HOSPITAL   (United Kingdom)

^o TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^p TAMPERE UNIVERSITY HOSPITAL   (Finland)

^q INSTITUTE OF EPIDEMIOLOGY   (Germany)

^r UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^s GROUP HEALTH RESEARCH INSTITUTE   (United States)

^t UNIVERSITY OF NORTH CAROLINA   (United States)

^u UNIVERSITY OF TURKU   (Finland)

^v TURKU UNIVERSITY HOSPITAL   (Finland)

^w UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^x Milan Unit   (Italy)

^y UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^z BRIGHAM AND WOMEN S HOSPITAL   (United States)

^aa UNIVERSITY OF WASHINGTON   (United States)

^ab BAYLOR COLLEGE OF MEDICINE   (United States)

^ac HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^ad BEN TAUB GENERAL HOSPITAL   (United States)

^ae TEL AVIV UNIVERSITY   (Israel)

^af INTERNATIONAL COMPUTER SCIENCE INSTITUTE   (United States)

^ag WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^ah UNIVERSITY OF HELSINKI   (Finland)

^ai UNIVERSITY OF ICELAND   (Iceland)

^aj MASSACHUSETTS GENERAL HOSPITAL   (United States)

^ak BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^al UNIVERSITY OF PENNSYLVANIA   (United States)

^am CEDARS SINAI MEDICAL CENTER   (United States)

^an Klinikum Herford   (Germany)

^ao HANNOVER MEDICAL SCHOOL   (Germany)

^ap Santa Barbara Hospital   (Italy)

^aq BALTIMORE VA MEDICAL CENTER   (United States)

^ar LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^as NATIONAL INSTITUTE ON AGING   (United States)

^at Boston University   (United States)

^au TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^av UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^aw UNIVERSITY OF LEIPZIG   (Germany)

^ax NATIONAL INSTITUTE ON AGING   (United States)

^ay BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^az HEINRICH HEINE UNIVERSITY   (Germany)

^ba UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^bb UNIVERSITY OF EDINBURGH   (United Kingdom)

^bc UNIVERSITY OF TURKU   (Finland)

^bd UNIVERSITY HOSPITAL ULM   (Germany)

^be UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD PRESSURE REGULATION; CHROMOSOME 19; CHROMOSOME 8; CORONARY ARTERY DISEASE; GENE MAPPING; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; LIPID METABOLISM; MAJOR CLINICAL STUDY; META ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGING; ATHEROSCLEROSIS; CAROTID INTIMA-MEDIA THICKNESS; COHORT STUDIES; CORONARY ARTERY DISEASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEART; HUMANS; MIDDLE AGED; PHENOTYPE; PLAQUE, ATHEROSCLEROTIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 80053385049     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.920     Document Type: Article

References (36)

1. Lloyd-Jones, D. et al. Executive summary: heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 121, 948-954 (2010
2. Falk, E. Pathogenesis of atherosclerosis. J. Am. Coll. Cardiol. 47, C7-C12 (2006
3. Insull, W. Jr. The pathology of atherosclerosis: plaque development and plaque responses to medical treatment. Am. J. Med. 122, S3-S14 (2009
4. Ross, R. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340, 115-126 (1999
5. Lorenz, M.W., Markus, H.S., Bots, M.L., Rosvall, M. & Sitzer, M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 115, 459-467 (2007 (Pubitemid 46184197)
6. Stein, J.H. et al. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J. Am. Soc. Echocardiogr. 21, 93-111 quiz 189-190 (2008 (Pubitemid 351193107)
7. Greenland, P. et al. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 122, e584-e636 (2010
8. Johnsen, S.H. et al. Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: a 6-year follow-up study of 6,226 persons: the Tromso Study. Stroke 38, 2873-2880 (2007 (Pubitemid 350035678)
9. Mathiesen, E.B. et al. Carotid plaque area and intima-media thickness in prediction of first-ever ischemic stroke: a 10-year follow-up of 6,584 men and women: the Tromso Study. Stroke 42, 972-978 (2011
10. Nambi, V. et al. Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study. J. Am. Coll. Cardiol. 55, 1600-1607 (2010
11. Manolio, T.A., Boerwinkle, E., O Donnell, C.J. & Wilson, A.F. Genetics of ultrasonographic carotid atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 24, 1567-1577 (2004 (Pubitemid 39180878)
12. Wang, D. et al. A genome-wide scan for carotid artery intima-media thickness: the Mexican-American Coronary Artery Disease family study. Stroke 36, 540-545 (2005 (Pubitemid 40344153)
13. Fox, C.S. et al. Genomewide linkage analysis for internal carotid artery intimal medial thickness: evidence for linkage to chromosome 12. Am. J. Hum. Genet. 74, 253-261 (2004 (Pubitemid 38168613)
14. Schunkert, H. et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat. Genet. 43, 333-338 (2011
15. Bennet, A.M. et al. Association of apolipoprotein E genotypes with lipid levels and coronary risk. J. Am. Med. Assoc. 298, 1300-1311 (2007 (Pubitemid 47443344)
16. Paternoster, L. et al. Genetic effects on carotid intima-media thickness: systematic assessment and meta-analyses of candidate gene polymorphisms studied in more than 5,000 subjects. Circ. Cardiovasc. Genet. 3, 15-21 (2010
17. Chasman, D.I. et al. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet. 5, e1000730 (2009
18. Zhou, X.Z. & Lu, K.P. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107, 347-359 (2001 (Pubitemid 33049978)
19. Yuan, K. et al. PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation. J. Biol. Chem. 284, 23072-23082 (2009
20. Kolz, M. et al. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 5, e1000504 (2009
21. Dehghan, A. et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet 372, 1953-1961 (2008
22. Meisinger, C., Koenig, W., Baumert, J. & Doring, A. Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study. Arterioscler. Thromb. Vasc. Biol. 28, 1186-1192 (2008
23. Stark, K. et al. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. PLoS ONE 4, e7729 (2009
24. Soranzo, N. et al. A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function. Blood 113, 3831-3837 (2009
25. Johnson, A.D. et al. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat. Genet. 42, 608-613 (2010
26. Nakov, R., Pfarr, E. & Eberle, S. Darusentan: an effective endothelinA receptor antagonist for treatment of hypertension. Am. J. Hypertens. 15, 583-589 (2002 (Pubitemid 34734804)
27. Rahman, T., Baker, M., Hall, D.H., Avery, P.J. & Keavney, B. Common genetic variation in the type A endothelin-1 receptor is associated with ambulatory blood pressure: a family study. J. Hum. Hypertens. 22, 282-288 (2008 (Pubitemid 351419496)
28. Yasuda, H. et al. Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension. J. Hum. Hypertens. 21, 883-892 (2007 (Pubitemid 350020340)
29. Oguri, M. et al. Association of genetic variants with myocardial infarction in Japanese individuals with metabolic syndrome. Atherosclerosis 206, 486-493 (2009
30. Chasman, D.I. et al. Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6,382 white women in genome-wide analysis with replication. Circ. Cardiovasc. Genet. 1, 21-30 (2008
31. Sabatti, C. et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat. Genet. 41, 35-46 (2009
32. Kathiresan, S. et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat. Genet. 41, 56-65 (2009
33. Aulchenko, Y.S. et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat. Genet. 41, 47-55 (2009
34. Kathiresan, S. et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat. Genet. 41, 334-341 (2009
35. Psaty, B.M. et al. Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ. Cardiovasc. Genet. 2, 73-80 (2009
36. Johnson, A.D. & O Donnell, C.J. An open access database of genome-wide association results. BMC Med. Genet. 10, 6 (2009