A myocardial infarction genetic risk score is associated with markers of carotid atherosclerosis

Journal of Internal Medicine

Volumn 271, Issue 3, 2012, Pages 271-281

  Hamrefors, V ^a   Hedblad, B ^a   Engstrom G ^a   Almgren, P ^a   Sjogren M ^a   Melander, O ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Carotid atherosclerosis; Carotid IMT; Chromosome 9p21; Genetic score; Myocardial infarction genetics; Single nucleotide polymorphisms

Indexed keywords

C REACTIVE PROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGED; ARTERY DIAMETER; ARTERY INTIMA; ARTERY MEDIA; ARTICLE; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; CAROTID ATHEROSCLEROSIS; CHROMOSOME 9P; COMMON CAROTID ARTERY; CORONARY ARTERY DISEASE; FEMALE; GENETIC RISK; GENOTYPE; HEART INFARCTION; HEREDITY; HUMAN; MALE; MEDICAL DECISION MAKING; PHENOTYPE; POPULATION; PRIORITY JOURNAL; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

AGED; BIOLOGICAL MARKERS; CAROTID ARTERY DISEASES; COHORT STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; RISK FACTORS; SWEDEN;

EID: 84857627637     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2011.02472.x     Document Type: Article

References (39)

1. Lloyd-Jones DM, Nam BH, D'Agostino RB Sr et al. Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA 2004; 291: 2204-11.
2. Kathiresan S, Willer CJ, Peloso GM et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2009; 41: 56-65.
3. Newton-Cheh C, Johnson T, Gateva V et al. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009; 41: 666-76.
4. Kathiresan S, Melander O, Anevski D et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med 2008; 358: 1240-9.
5. McPherson R, Pertsemlidis A, Kavaslar N et al. A common allele on chromosome 9 associated with coronary heart disease. Science 2007; 316: 1488-91.
6. Helgadottir A, Thorleifsson G, Manolescu A et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 2007; 316: 1491-3.
7. Samani NJ, Erdmann J, Hall AS et al. Genomewide association analysis of coronary artery disease. N Engl J Med 2007; 357: 443-53.
8. Visel A, Zhu Y, May D et al. Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 2010; 464: 409-12.
9. Patel RS, Su S, Neeland IJ et al. The chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease. Eur Heart J 2010; 31: 3017-23.
10. Muendlein A, Saely CH, Rhomberg S et al. Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease. Atherosclerosis 2009; 205: 174-80.
11. Ye S, Willeit J, Kronenberg F, Xu Q, Kiechl S. Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study. J Am Coll Cardiol 2008; 52: 378-84.
12. Cluett C, McDermott MM, Guralnik J et al. The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet 2009; 2: 347-53.
13. Chen SN, Ballantyne CM, Gotto AM Jr, Marian AJ. The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis. BMC Cardiovasc Disord 2009; 9: 3.
14. Anderson JL, Horne BD, Kolek MJ et al. Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility. Am Heart J 2008; 156: 1155-62 e2.
15. Samani NJ, Raitakari OT, Sipila K et al. Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis. Arterioscler Thromb Vasc Biol 2008; 28: 1679-83.
16. Cunnington MS, Mayosi BM, Hall DH et al. Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes. Atherosclerosis 2009; 203: 41-4.
17. Hiura Y, Fukushima Y, Yuno M et al. Validation of the association of genetic variants on chromosome 9p21 and 1q41 with myocardial infarction in a Japanese population. Circ J 2008; 72: 1213-7.
18. Lanktree MB, Hegele RA, Yusuf S, Anand SS. Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray. Stroke 2009; 40: 3173-9.
19. O'Donnell CJ, Cupples LA, D'Agostino RB et al. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. BMC Med Genet 2007; 8(Suppl 1): S4.
20. Kathiresan S, Voight BF, Purcell S et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet 2009; 41: 334-41.
21. Erdmann J, Grosshennig A, Braund PS et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet 2009; 41: 280-2.
22. Gudbjartsson DF, Bjornsdottir US, Halapi E et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 2009; 41: 342-7.
23. Tregouet DA, Konig IR, Erdmann J et al. Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet 2009; 41: 283-5.
24. Schunkert H, Konig IR, Kathiresan S et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 2011; 43: 333-8.
25. Stein JH, Korcarz CE, Hurst RT et al. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr 2008; 21: 93-111; quiz 89-90..
26. Graner M, Varpula M, Kahri J et al. Association of carotid intima-media thickness with angiographic severity and extent of coronary artery disease. Am J Cardiol 2006; 97: 624-9.
27. Kablak-Ziembicka A, Przewlocki T, Tracz W et al. Diagnostic value of carotid intima-media thickness in indicating multi-level atherosclerosis. Atherosclerosis 2007; 193: 395-400.
28. Amato M, Montorsi P, Ravani A et al. Carotid intima-media thickness by B-mode ultrasound as surrogate of coronary atherosclerosis: correlation with quantitative coronary angiography and coronary intravascular ultrasound findings. Eur Heart J 2007; 28: 2094-101.
29. Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 2007; 115: 459-67.
30. Ripatti S, Tikkanen E, Orho-Melander M et al. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. Lancet 2010; 376: 1393-400.
31. Rosvall M, Janzon L, Berglund G, Engstrom G, Hedblad B. Incident coronary events and case fatality in relation to common carotid intima-media thickness. J Intern Med 2005; 257: 430-7.
32. Rosvall M, Janzon L, Berglund G, Engstrom G, Hedblad B. Incidence of stroke is related to carotid IMT even in the absence of plaque. Atherosclerosis 2005; 179: 325-31.
33. Berglund G, Elmstahl S, Janzon L, Larsson SA. The Malmo Diet and Cancer Study. Design and feasibility. J Intern Med 1993; 233: 45-51.
34. Liao YC, Lin HF, Rundek T et al. Segment-specific genetic effects on carotid intima-media thickness: the Northern Manhattan study. Stroke 2008; 39: 3159-65.
35. Aulchenko YS, Ripatti S, Lindqvist I et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 2009; 41: 47-55.
36. Ebrahim S, Papacosta O, Whincup P et al. Carotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: the British Regional Heart Study. Stroke 1999; 30: 841-50.
37. O'Leary DH, Polak JF, Kronmal RA et al. Thickening of the carotid wall. A marker for atherosclerosis in the elderly? Cardiovascular Health Study Collaborative Research Group. Stroke 1996; 27: 224-31.
38. Reilly MP, Li M, He J et al. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet 2011; 377: 383-92.
39. Rosvall M, Ostergren PO, Hedblad B, Isacsson SO, Janzon L, Berglund G. Occupational status, educational level, and the prevalence of carotid atherosclerosis in a general population sample of middle-aged Swedish men and women: results from the Malmo Diet and Cancer Study. Am J Epidemiol 2000; 152: 334-46.