MiR-106b modulates cancer stem cell characteristics through TGF-β/Smad signaling in CD44-positive gastric cancer cells

Laboratory Investigation

Volumn 94, Issue 12, 2014, Pages 1370-1381

  Yu, Dayeon ^a   Shin, Hyun Soo ^b   Lee, Yeo Song ^a   Lee, Yong Chan ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CD44V ANTIGEN; MICRO RNA 106B; MICRORNA; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CD44 PROTEIN, HUMAN; HERMES ANTIGEN; MIRN106 MICRORNA, HUMAN;

ARTICLE; CANCER STEM CELL; CELL INVASION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FLUORESCENCE ACTIVATED CELL SORTING; GASTRIC CANCER CELL LINE; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MICROARRAY ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; PATHOLOGY; PHYSIOLOGY; STOMACH TUMOR; TUMOR CELL LINE; TUMOR INVASION;

ANTIGENS, CD44; CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASTIC STEM CELLS; SIGNAL TRANSDUCTION; SMAD PROTEINS; STOMACH NEOPLASMS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84922479594     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2014.125     Document Type: Article

References (31)

1. Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-2917.
2. Jemal A, Center MM, DeSantis C, et al. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev 2010;19:1893-1907.
3. Jordan CT, Guzman ML, Noble M. Cancer stem cells. New Engl J Med 2006;355:1253-1261.
4. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-737.
5. Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003;63:5821-5828.
6. Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci 2003;100:3983-3988.
7. Takaishi S, Okumura T, Tu S, et al. Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells 2009;27: 1006-1020.
8. Zhang C, Li C, He F, et al. Identification of CD44 CD24 gastric cancer stem cells. J Cancer Res Clin 2011;137:1679-1686.
9. Rocco A, Compare D, Nardone G. Cancer stem cell hypothesis and gastric carcinogenesis: experimental evidence and unsolved questions. World J Gastrointest Oncol 2012;4:54-59.
10. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2:442-454.
11. Mani SA, Guo W, Liao M-J, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008;133:704-715.
12. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-297.
13. Shimono Y, Zabala M, Cho RW, et al. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 2009;138: 592-603.
14. Liu C, Kelnar K, Liu B, et al. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 2011;17:211-215.
15. Guo J, Miao Y, Xiao B, et al. Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues. J Gastroen Hepatol 2009;24:652-657.
16. Kim YK, Yu J, Han TS, et al. Functional links between clustered microRNAs: suppression of cell-cycle inhibitors by microRNA clusters in gastric cancer. Nucleic Acids Res 2009;37:1672-1681.
17. Ambs S, Prueitt RL, Yi M, et al. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res 2008;68:6162-6170.
18. Hayashita Y, Osada H, Tatematsu Y, et al. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res 2005;65:9628-9632.
19. Ivanovska I, Ball AS, Diaz RL, et al. MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol 2008;28:2167-2174.
20. Petrocca F, Vecchione A, Croce CM. Emerging role of miR-106b-25/ miR-17-92 clusters in the control of transforming growth factor b signaling. Cancer Res 2008;68:8191-8194.
21. Guo W, Lasky JL, Wu H. Cancer stem cells. Pediatr Res 2006;59: 59R-64R.
22. Nishikawa S, Konno M, Hamabe A, et al. Aldehyde dehydrogenase high gastric cancer stem cells are resistant to chemotherapy. Int J Oncol 2013;42:1437-1442.
23. Blenkiron C, Goldstein LD, Thorne NP, et al. MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol 2007;8:R214.
24. Rothe F, Ignatiadis M, Chaboteaux C, et al. Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer. PLoS One 2011;6:e20980.
25. Singh A, Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010;29: 4741-4751.
26. Morel A-P, Lievre M, Thomas C, et al. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PloS One 2008;3:e2888.
27. James D, Levine AJ, Besser D, et al. TGFb/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development 2005;132:1273-1282.
28. Smith A, Iwanaga R, Drasin D, et al. The miR-106b-25 cluster targets Smad7, activates TGF-b signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer. Oncogene 2012;31:5162-5171.
29. Yau WL, Lam CSC, Ng L, et al. Over-expression of miR-106b promotes cell migration and metastasis in hepatocellular carcinoma by activating epithelial-mesenchymal transition process. PloS One 20138.
30. Ebisawa T, Fukuchi M, Murakami G, et al. Smurf1 interacts with transforming growth factor-b type I receptor through Smad7 and induces receptor degradation. J Biol Chem 2001;276:12477-12480.
31. Nakao A, Afrakhte M, Morn A, et al. Identification of Smad7, a TGFbinducible antagonist of TGF-b signalling. Nature 1997;389:631-635.