Aldehyde dehydrogenasehigh gastric cancer stem cells are resistant to chemotherapy

International Journal of Oncology

Volumn 42, Issue 4, 2013, Pages 1437-1442

  Nishikawa, Shimpei ^a   Konno, Masamitsu ^a   Hamabe, Atsushi ^a   Hasegawa, Shinichiro ^a   Kano, Yoshihiro ^a   Ohta, Katsuya ^a   Fukusumi, Takahito ^a   Sakai, Daisuke ^a   Kudo, Toshihiro ^a   Haraguchi, Naotsugu ^a   Satoh, Taroh ^a   Takiguchi, Shuji ^a   Mori, Masaki ^a   Doki, Yuichiro ^a   Ishii, Hideshi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Aldehyde dehydrogenase; Cancer stem cells; Chemotherapy resistance; Gastric cancer

Indexed keywords

ALDEHYDE DEHYDROGENASE; CD133 ANTIGEN; CISPLATIN; DIPEPTIDYL PEPTIDASE IV; EPITHELIAL CELL ADHESION MOLECULE; FLUOROURACIL; HERMES ANTIGEN; MICROSOMAL AMINOPEPTIDASE; NOTCH1 RECEPTOR; SONIC HEDGEHOG PROTEIN; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; CANCER CELL CULTURE; CANCER STEM CELL; CARCINOGENICITY; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOMACH CANCER;

ALDEHYDE DEHYDROGENASE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CISPLATIN; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; HEDGEHOG PROTEINS; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84874592312     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.1837     Document Type: Article

References (34)

1. Bonnet D and Dick JE: Human acute leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3:730-737, 1997.
2. Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer and cancer stem cells. Nature 414:105-111, 2001.
3. Prince ME, Sivanandan R, Kaczorowski A, et al: Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA 104:973-978, 2007.
4. Haraguchi N, Utsunomiya T, Inoue H, Tanaka F, Mimori K, Barnard GF and Mori M: Characterization of a side population of cancer cells from human gastrointestinal system. Stem Cell 24:506-513, 2006.
5. Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C and De Maria R: Identification and expansion of human colon-cancer-initiating cells. Nature 445:111-115, 2007.
6. O'Brien CA, Pollett A, Gallinger S and Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445:106-110, 2007.
7. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ and Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100:3983-3988, 2003.
8. Piccirillo SG, Reynolds BA, Zanetti N, et al: Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444:761-765, 2006.
9. Bao S, Wu Q, McLendon RE, et al: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-760, 2006.
10. Ishii H, Iwatsuki M, Ieta K, Ohta D, Haraguchi N, Mimori K and Mori M: Cancer stem cells and chemoradiation resistance. Cancer Sci 99:1871-1877, 2008.
11. Dewi DL, Ishii H, Kano Y, et al: Cancer stem cell theory in gastrointestinal malignancies: recent progress and upcoming challenges. J Gastroenterol 46:1145-1157, 2011.
12. Haraguchi N, Ishii H, Mimori K, et al: CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest 120:3326-3339, 2010.
13. Tamada M, Nagano O, Tateyama S, et al: Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells. Cancer Res 72:1438-1448, 2012.
14. Ishimoto T, Nagano O, Yae T, et al: CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc (-) and thereby promotes tumor growth. Cancer Cell 19:387-400, 2011.
15. Marcato P, Dean CA, Giacomantonio CA and Lee PW: Aldehyde dehydrogenase: its role as a cancer stem cell marker comes down to the specific isoform. Cell Cycle 10:1378-1384, 2011.
16. Ginestier C, Hur MH, Charafe-Jauffret E, et al: ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1:555-567, 2007.
17. Feldmann G, Dhara S, Fendrich V, et al: Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 67:2187-2196, 2007.
18. Ma S, Chan KW, Lee TK, Tang KH, Wo JY, Zheng BJ and Guan XY: Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Mol Cancer Res 6:1146-1153, 2008.
19. Huang EH, Hynes MJ, Zhang T, et al: Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 69:3382-3389, 2009.
20. Todaro M, Iovino F, Eterno V, et al: Tumorigenic and metastatic activity of human thyroid cancer stem cells. Cancer Res 70:8874-8885, 2010.
21. Sullivan J P, Spinola M, Dodge M, et al: Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res 70:9937-9948, 2010.
22. Ma I and Allan AL: The role of human aldehyde dehydrogenase in normal and cancer stem cells. Stem Cell Rev 7:292-306, 2011.
23. Wakamatsu Y, Sakamoto N, Oo HZ, et al: Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer. Pathol Int 62:112-119, 2012.
24. Takaishi S, Okumura T, Tu S, et al: Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cell 27:1006-1020, 2009.
25. Han ME, Jeon TY, Hwang SH, et al: Cancer spheres from gastric cancer patients provide an ideal model system for cancer stem cell research. Cell Mol Life Sci 68:3589-3605, 2011.
26. Chen T, Yang K, Yu J, et al: Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients. Cell Res 22:248-258, 2012.
27. Fukuda K, Saikawa Y, Ohashi M, et al: Tumor initiating potential of side population cells in human gastric cancer. Int J Oncol 34:1201-1207, 2009.
28. Jiang J, Zhang Y, Chuai S, et al: Trastuzumab (herceptin) targets gastric cancer stem cells characterized by CD90 phenotype. Oncogene 31:671-682, 2012.
29. Katsuno Y, Ehata S, Yashiro M, Yanagihara K, Hirakawa K and Miyazono K: Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-ß. J Pathol 228:391-404, 2012.
30. Marshall BJ and Warren JR: Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 16:1311-1315, 1984.
31. Suganuma M, Yamaguchi K, Ono Y, et al: TNF-alpha-inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells. Int J Cancer 123:117-122, 2008.
32. Sinkovics JG: Molecular biology of oncogenic inflammatory processes. I. Non-oncogenic and oncogenic pathogens, intrinsic inflammatory reactions without pathogens and microRNA/DNA interactions (Review). Int J Oncol 40:305-349, 2012.
33. Bhattacharyya A, Chattopadhyay R, Hall EH, Mebrahtu ST, Ernst PB and Crowe SE: Mechanism of hypoxia-inducible factor 1 alpha-mediated Mcl1 regulation in Helicobacter pyloriinfected human gastric epithelium. Am J Physiol Gastrointest Liver Physiol 299:G1177-G1186, 2010.
34. Barker HE, Cox TR and Erler JT: The rationale for targeting the LOX family in cancer. Nat Rev Cancer 12:540-552, 2012.