Expression of homologous RND efflux pump genes is dependent upon AcrB expression: Implications for efflux and virulence inhibitor design

Journal of Antimicrobial Chemotherapy

Volumn 70, Issue 2, 2015, Pages 424-431

  Blair, Jessica M A ^a   Smith, Helen E ^a   Ricci, Vito ^a   Lawler, Amelia J ^a   Thompson, Louisa J ^a   Piddock, Laura J V ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

AcrB; AcrD; AcrF; Redundancy

Indexed keywords

ACRB PROTEIN; ACRD PROTEIN; ACRF PROTEIN; AMINOGLYCOSIDE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; RESISTANCE NODULATION DIVISION EFFLUX TRANSPORTER; UNCLASSIFIED DRUG; CARRIER PROTEIN;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BACTERIUM EXAMINATION; BACTERIUM MUTANT; COMPUTER MODEL; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE INACTIVATION; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; GENOTYPE; MICROBIAL SENSITIVITY TEST; MULTIDRUG RESISTANCE; MULTIGENE FAMILY; MUTATION; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; VIRULENCE;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; GENE SILENCING; GENOTYPE; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; MULTIGENE FAMILY; MUTATION; SALMONELLA TYPHIMURIUM; VIRULENCE;

EID: 84922473317     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dku380     Document Type: Article

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