RobA-induced multiple antibiotic resistance largely depends on the activation of the AcrAB efflux

Microbiology and Immunology

Volumn 41, Issue 9, 1997, Pages 697-702

  Tanaka, Toshihiko ^a   Horii, Toshinobu ^a   Shibayama, Keigo ^a   Sato, Kumiko ^a   Ohsuka, Shinji ^a   Arakawa, Yoshichika ^b   Yamaki, Ken Ichi ^a   Takagi, Kenzo ^a   Ohta, Michio ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

AcrAB; Efflux; Multiple antibiotic resistance; RobA

Indexed keywords

AMPICILLIN; BETA LACTAM ANTIBIOTIC; CEFOPERAZONE; CEFOTAXIME; CHLORAMPHENICOL; DNA BINDING PROTEIN; DNA FRAGMENT; ENOXACIN; MINOCYCLINE; NALIDIXIC ACID; NORFLOXACIN; OFLOXACIN; OUTER MEMBRANE PROTEIN; PORIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL OUTER MEMBRANE; DNA REPLICATION ORIGIN; ESCHERICHIA COLI; GENE CONTROL; GENE EXPRESSION; GENE LOCATION; GENE OVEREXPRESSION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLASMID;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0030924112     PISSN: 03855600     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1348-0421.1997.tb01913.x     Document Type: Article

References (19)

1. Aiba, H., Nakasai, F., Mizushima, S., and Mizuno, T. 1989. Evidence for the physiological importance of the phosphotransfer between the two regulatory components, EnvZ and OmpR, in osmoregulation in Escherichia coli. J. Biol. Chem. 264: 14090-14094.
2. Arakawa, Y., Wacharotayankun, R., Nagatsuka, T., Ito, H., Kato, N., and Ohta, M. 1995. Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid. J. Bacteriol. 177: 1788-1796.
3. Ariza, R.R., Li, Z., Ringstad, N., and Demple, B. 1995. Activation of multiple antibiotic resistance and binding of stress-induced promoters by Escherichia coli Rob protein. J. Bacteriol. 177: 1655-1661.
4. Harder, K.J., Nikaido, H., and Matsuhashi, M. 1981. Mutants of Escherichia coli that are resistant to certain β-lactam compounds lack the OmpF porin. Antimicrob. Agents Chemother. 20: 549-552.
5. MOX-1 gene encoding AmpC-type β-lactamase. Gene 139: 93-98.
6. Jair, K.-W., Yu, X., Skarstad, K., Thöny, B., Fujita, N., Ishihama, A., and Wolf, R.E., Jr. 1996. Transcriptional activation of promoters of the superoxide and multiple antibiotic resistance regulons by Rob, a binding protein of the Escherichia coli origin of chromosomal replication. J. Bacteriol. 178: 2507-2513.
7. Komatsu, T., Ohta, M., Kido, N., Arakawa, Y., Ito, H., and Kato, N. 1991. Increased resistance to multiple drugs by introduction of the Enterobacter cloacae romA gene into OmpF porin-deficient mutants of Escherichia coli K-12. Antimicrob. Agents Chemother. 35: 2155-2158.
8. Lee, E.-H., Collatz, E., Podglajen, I., and Gutmann, L. 1996. A rob-like gene of Enterobacter cloacae affecting porin synthesis and susceptibility to multiple antibiotics. Antimicrob. Agents Chemother. 40: 2029-2033.
9. Ma, D., Alberti, M., Lynch, C., Nikaido, H., and Hearst, J.E. 1996. The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals. Mol. Microbiol. 19: 101-112.
10. Mizuno, T., Chou, M.Y., and Inouye, M. 1984. A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA). Proc. Natl. Acad. Sci. U.S.A. 81: 1966-1970.
11. Mizuno, T., Kato, M., Jo, Y.-L., and Mizushima, S. 1988. Interaction of OmpR, a positive regulator, with the osmoregulated ompC and ompF genes of Escherichia coli. J. Biol. Chem. 263: 1008-1012.
12. Nagasawa, S., Ishige, K., and Mizuno, T. 1993. Novel members of the two-component signal transduction genes in Escherichia coli. J. Biochem. (Tokyo) 114: 350-357.
13. Nakajima, H., Kobayashi, K., Kobayashi, M., Asako, H., and Aono, R. 1995. Overexpression of the robA gene increases organic solvent tolerance and multiple antibiotic and heavy metal ion resistance in Escherichia coli. Appl. Environ. Microbiol. 61: 2302-2307.
14. Nakamura, H., Tojo, T., and Greenberg, J. 1975. Interaction of the expression of two membrane genes, acrA and plsA, in Escherichia coli K-12. J. Bacteriol. 122: 874-879.
15. Nara, F., Matsuyama, S., Mizuno, T., and Mizushima, S. 1986. Molecular analysis of mutant ompR genes exhibiting different phenotypes as to osmoregulation of the ompF and ompC genes of Escherichia coli. Mol. Gen. Genet. 202: 194-199.
16. Okusu, H., Ma, D., and Nikaido, H. 1996. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple antibiotic-resistance (Mar) mutants. J. Bacteriol. 178: 306-308.
17. Rosner, J.L., and Slonczewski, J.L. 1994. Dual regulation of inaA by the multiple antibiotic resistance (Mar) and superoxide (SoxRS) stress response systems of Escherichia coli. J. Bacteriol. 176: 6262-6269.
18. Sambrook, J., Fritsch, E.F., and Maniatis, T. 1989. Molecular cloning: a laboratory manual, 2nd ed, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
19. Skarstad, K., Thöny, B., Hwang, D.S., and Kornberg, A. 1993. A novel binding protein of the origin of the Escherichia coli chromosome. J. Biol. Chem. 268: 5365-5370.