AcrD of Escherichia coli is an aminoglycoside efflux pump

Journal of Bacteriology

Volumn 182, Issue 6, 2000, Pages 1754-1756

  Rosenberg, Emiko Y ^a   Ma, Dzwokai ^a,b   Nikaido, Hiroshi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; DIHYDROSTREPTOMYCIN; ERYTHROMYCIN; GENTAMICIN; KANAMYCIN; NEOMYCIN; POLYMYXIN B; TOBRAMYCIN;

ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG TRANSPORT; ESCHERICHIA COLI; GENE DELETION; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CARRIER PROTEINS; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; GENE DELETION; MICROBIAL SENSITIVITY TESTS;

ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0034090541     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.182.6.1754-1756.2000     Document Type: Article

References (21)

1. Aires, J. R., T. Köhler, H. Nikaido, and P. Plésiat. 1999. Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides. Antimicrob. Agents Chemother. 43:2624-2628.
2. Altschul, S. F., T. L. Madden, A. A. Schäffer, J. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSl-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:3389-3402.
3. Campbell, B. D., and R. J. Kadner, 1980. Relation of aerobiosis and ionic strength to the uptake of dihydrostreptomycin in Escherichia coli. Biochim. Biophys. Acta 593:1-10.
4. Davis, B. D. 1987. Mechanism of bactericidal action of aminoglycosides. Microbiol. Rev. 51:341-350.
5. Fraimow, H. S., J. B. Greenman, I. M. Leviton, T. J. Dougherty, and M. H. Miller. 1991. Tobramycin uptake in Escherichia coli is driven by either electrical potential or ATP. J. Bacteriol. 173:2800-2808.
6. Fralick, J. A. 1996. Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli. J. Bacteriol. 178:5803-5805.
7. Kashiwagi, K., M. H. Tsuhako, K. Sakata, T. Saisho, A. Igarashi, S. O. Pinto da Costa, and K. Igarashi. 1998. Relationship between spontaneous amino-glycoside resistance in Escherichia coli and a decrease in oligopeptide binding protein. J. Bacteriol. 180:5484-5488.
8. Ma, D., D. N. Cook, M. Alberti, J. E. Hearst, and H. Nikaido. 1994. Efflux pumps and drug resistance in gram-negative bacteria. Trends Microbiol. 2:489-493.
9. Ma, D., D. N. Cook, M. Alberti, N. G. Pon, H. Nikaido, and J. E. Hearst. 1993. Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J. Bacteriol. 175:6299-6313.
10. Ma, D., D. N. Cook, M. Alberti, N. G. Pon, H. Nikaido, and J. E. Hearst. 1995. Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol. Microbiol. 16:45-55.
11. Mates, S. M., E. S. Eisenberg, L. J. Mandel, L. Patel, H. R. Kaback, and M. H. Miller. 1982. Membrane potential and gentamicin uptake in Staphylococcus aureus. Proc. Natl. Acad. Sci. USA 79:6693-6697.
12. Medeiros, A. A., T. F. O'Brien, W. E. C. Wacker, and N. F. Yulug. 1971. Effect of salt concentration on the apparent in-vitro susceptibility of Pseudomonas and other Gram-negative bacilli to gentamicin. J. Infect. Dis. 124: S59-S64.
13. Moore, R. A., D. DeShazer, S. Reckseidler, A. Weissman, and D. E. Woods. 1999. Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei. Antimicrob. Agents Chemother. 43:465-470.
14. Mühlradt, P. F., J. Menzel, J. R. Golecki, and V. Speth. 1974. Lateral mobility and surface density of lipopolysaccharide in the outer membrane of Salmonella typhimurium. Eur. J. Biochem. 43:533-539.
15. Neidhardt, F. C., P. L. Bloch, and D. F. Smith. 1974. Culture medium for enterobacteria. J. Bacteriol. 119:736-747.
16. Nikaido, H. 1996. Multidrug efflux pumps of gram-negative bacteria. J. Bacteriol. 178:5853-5859.
17. Nikaido, H. 1998. Multiple antibiotic resistance and efflux. Curr. Opin. Microbiol. 1:516-523.
18. Okusu, H., D. Ma, and H. Nikaido. 1996. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J. Bacteriol. 178:306-308.
19. Saier, M. H., Jr., R. Tam, A. Reizer, and J. Reizer. 1994. Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport. Mol. Microbiol. 11:841-847.
20. Thanassi, D. G., L. W. Cheng, and H. Nikaido. 1997. Active efflux of bile salts by Escherichia coli. J. Bacteriol. 179:2512-2518.
21. Wu, B., C. Georgopoulos, and D. Ang. 1992. The essential Escherichia coli msgB gene, a multicopy suppressor of a temperature-sensitive allele of the heat shock gene grpE, is identical to dapE. J. Bacteriol. 174:5258-5264.