Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol

Journal of Biological Chemistry

Volumn 290, Issue 6, 2015, Pages 3519-3528

  Zhang, Chongben ^a   Hwarng, Gwen ^a   Cooper, Daniel E ^a   Grevengoed, Trisha J ^a   Eaton, James M ^b   Natarajan, Viswanathan ^c   Harris, Thurl E ^b   Coleman, Rosalind A ^a  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCEROL; LIPIDS;

DE NOVO SYNTHESIS; DIACYLGLYCEROL KINASE; INSULIN RESISTANCE; INSULIN SIGNALING; PHOSPHATIDIC ACIDS; PHOSPHOLIPASE D; PRIMARY HEPATOCYTES; TRIACYLGLYCEROLS;

INSULIN;

1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; COMPLEMENTARY DNA; DIACYLGLYCEROL; DIACYLGLYCEROL KINASE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; GLYCEROPHOSPHATE; INSULIN; INSULIN RECEPTOR SUBSTRATE; ISOPROTEIN; PHOSPHATIDIC ACID; PHOSPHOLIPASE D; PHOSPHOLIPASE D1; PHOSPHOLIPASE D2; PROTEIN KINASE C; TRIACYLGLYCEROL; CARRIER PROTEIN; RICTOR PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HYDROLYSIS; IMMUNOPRECIPITATION; INSULIN RESISTANCE; LIVER CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; C57BL MOUSE; CELL CULTURE; GENETICS; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; DIACYLGLYCEROL KINASE; DIGLYCERIDES; GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE; HEPATOCYTES; INSULIN; MICE; MICE, INBRED C57BL; PHOSPHATIDIC ACIDS; PHOSPHOLIPASE D; PROTEIN KINASE C; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84922470711     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.602789     Document Type: Article

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