A transcriptional roadmap to the senescence and differentiation of human oral keratinocytes

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 70, Issue 1, 2015, Pages 20-32

  Jang, Da Hyun ^a   Bhawal, Ujjal K ^b   Min, Hong Ki ^c   Kang, Hyun Ki ^a   Abiko, Yoshimitsu ^b   Min, Byung Moo ^a  

^a Seoul National University   (South Korea)

^b NIHON UNIVERSITY   (Japan)

^c The Catholic University of Korea   (South Korea)

Author keywords

cell differentiation; gene network; Human oral keratinocytes; replicative senescence

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BHLHE40 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; INTERLEUKIN 1BETA; INVOLUCRIN; MESSENGER RNA; PROTEIN PRECURSOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

AGING; ANIMAL; APOPTOSIS; CELL AGING; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECTS; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; GENETICS; GINGIVA; HUMAN; KERATINOCYTE; METABOLISM; MOUSE; TUMOR SUPPRESSOR GENE;

AGING; ANIMALS; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; GENE REGULATORY NETWORKS; GENES, P16; GINGIVA; HOMEODOMAIN PROTEINS; HUMANS; INTERLEUKIN-1BETA; KERATINOCYTES; MICE; PROTEIN PRECURSORS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84922462201     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glt212     Document Type: Article

References (40)

1. Larjava H. Expression of beta 1 integrins in normal human keratinocytes. Am J Med Sci. 1991;301:63-68. doi:10.1097/00000441- 199101000-00012
2. Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 1995;92:9363-9367. doi:10.1073/pnas.92.20.9363
3. Watanabe Y, Lee SW, Detmar M, et al. Vascular permeability factor/ vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene. 1997;14:2025-2032. doi:10.1038/sj.onc.1201033
4. Bodnar AG, Ouellette M, Frolkis M, et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:349-352. doi:10.1126/science.279.5349.349
5. Min BM, Woo KM, Lee G, Park NH. Terminal differentiation of normal human oral keratinocytes is associated with enhanced cellular TGF-beta and phospholipase C-gamma 1 levels and apoptotic cell death. Exp Cell Res. 1999;249:377-385. doi:10.1006/excr.1999.4489
6. Kang MK, Guo W, Park NH. Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres. Cell Growth Differ. 1998;9:85-95.
7. Baek JH, Lee G, Kim SN, et al. Common genes responsible for differentiation and senescence of human mucosal and epidermal keratinocytes. Int J Mol Med. 2003;12:319-325
8. Schön M, Rheinwald JG. A limited role for retinoic acid and retinoic acid receptors RAR alpha and RAR beta in regulating keratin 19 expression and keratinization in oral and epidermal keratinocytes. J Invest Dermatol. 1996;107:428-438. doi:10.1111/1523-1747.ep12363411
9. Parkinson EK, Newbold RF, Keith WN. The genetic basis of human keratinocyte immortalisation in squamous cell carcinoma development: the role of telomerase reactivation. Eur J Cancer. 1997;33:727-734. doi:10.1016/S0959-8049(97)00063-4
10. Stein GH, Dulić V. Origins of G1 arrest in senescent human fibroblasts. Bioessays. 1995;17:537-543. doi:10.1002/bies.950170610
11. Hara E, Smith R, Parry D, et al. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol. 1996;16:859-867
12. Loughran O, Malliri A, Owens D, et al. Association of CDKN2A/ p16INK4A with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia. Oncogene. 1996;13:561-568
13. Rheinwald JG, Hahn WC, Ramsey MR, et al. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol. 2002;22:5157-5172. doi:10.1128/ MCB.22.14.5157-5172.2002
14. Kim RH, Lieberman MB, Lee R, et al. Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-beta signaling. Exp Cell Res. 2010;316:2600-2608. doi:10.1016/j.yexcr.2010.04.013
15. Di Cunto F, Topley G, Calautti E, et al. Inhibitory function of p21Cip1/ WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science. 1998;280:1069-1072. doi:10.1126/ science.280.5366.1069
16. Liu D, Sartor MA, Nader GA, et al. Microarray analysis reveals novel features of the muscle aging process in men and women. J Gerontol A Biol Sci Med Sci. 2013;68:1035-1044. doi:10.1093/gerona/glt015
17. Cogger VC, Svistounov D, Warren A, et al. Liver aging and pseudocapillarization in a Werner Syndrome mouse model. J Gerontol A Biol Sci Med Sci. 2013 October 22. doi:10.1093/gerona/glt169. doi:10.1093/gerona/glt169
18. Oh JE, Kook JK, Min BM. Big-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin α3β1 and the phosphatidylinositol 3-kinase/Akt signaling pathway. J Biol Chem. 2005;280:21629-21637. doi:10.1074/jbc. M412293200
19. Noordewier MO, Warren PV. Gene expression microarrays and the integration of biological knowledge. Trends Biotechnol. 2001;19:412-415. doi:10.1016/S0167-7799(01)01735-8
20. Minty F, Thurlow JK, Harrison PR, et al. Telomere dysfunction in human keratinocytes elicits senescence and a novel transcription profile. Exp Cell Res. 2008;314:2434-2447. doi:10.1016/j. yexcr.2008.05.007
21. Alcorta DA, Xiong Y, Phelps D, et al. Involvement of the cyclindependent kinase inhibitor p16INK4a in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci USA. 1996;93:13742-13747. doi:10.1073/pnas.93.24.13742
22. Uhrbom L, Nistér M, Westermark B. Induction of senescence in human malignant glioma cells by p16INK4A. Oncogene. 1997;15:505-514. doi:10.1038/sj.onc.1201227
23. Sarkar S, Das N. Mannosylated liposomal flavonoid in combating age-related ischemia-reperfusion induced oxidative damage in rat brain. Mech Ageing Dev. 2006;127:391-397. doi:10.1016/j. mad.2005.12.010
24. Dai SM, Shan ZZ, Nakamura H, et al. Catabolic stress induces features of chondrocyte senescence through overexpression of caveolin 1: possible involvement of caveolin 1-induced down-regulation of articular chondrocytes in the pathogenesis of osteoarthritis. Arthritis Rheum. 2006;54:818-831. doi:10.1002/art.21639
25. Green HF, Treacy E, Keohane AK, et al. A role for interleukin-1beta in determining the lineage fate of embryonic rat hippocampal neural precursor cells. Mol Cell Neurosci. 2012;49:311-321. doi:10.1016/j. mcn.2012.01.001
26. Koo JW, Duman RS. IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci USA. 2008;105:751-756. doi:10.1073/pnas.0708092105
27. Kuzumaki N, Ikegami D, Imai S, et al. Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice. Synapse. 2010;64:721-728. doi:10.1002/ syn.20800
28. Lee YM, Kim YK, Eun HC, et al. Changes in S100A8 expression in UV-irradiated and aged human skin in vivo. Arch Dermatol Res. 2009;301:523-529. doi:10.1007/s00403-009-0960-8
29. Yanamandra K, Alexeyev O, Zamotin V, et al. Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate. PLoS One. 2009;4:e5562. doi:10.1371/journal.pone.0005562
30. Ikoma T, Ozawa S, Suzuki K, et al. Calcium-calmodulin signaling induced by epithelial cell differentiation upregulates BRAK/CXCL14 expression via the binding of SP1 to the BRAK promoter region. Biochem Biophys Res Commun. 2012;420:217-222. doi:10.1016/j. bbrc.2012.01.157
31. Asumda FZ, Chase PB. Age-related changes in rat bone-marrow mesenchymal stem cell plasticity. BMC Cell Biol. 2011;12:44. doi:10.1186/1471-2121-12-44
32. Choudhery MS, Khan M, Mahmood R, et al. Bone marrow derived mesenchymal stem cells from aged mice have reduced wound healing, angiogenesis, proliferation and anti-apoptosis capabilities. Cell Biol Int. 2012;36:747-753. doi:10.1042/CBI20110183
33. Wilson A, Shehadeh LA, Yu H, et al. Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells. BMC Genomics. 2010;11:229. doi:10.1186/1471-2164-11-229
34. Reenstra WR, Yaar M, Gilchrest BA. Aging affects epidermal growth factor receptor phosphorylation and traffic kinetics. Exp Cell Res. 1996;227:252-255. doi:10.1006/excr.1996.0274
35. Ribault D, Habib M, Abdel-Majid K, et al. Age-related decrease in the responsiveness of rat articular chondrocytes to EGF is associated with diminished number and affinity for the ligand of cell surface binding sites. Mech Ageing Dev. 1998;100:25-40. doi:10.1016/ S0047-6374(97)00115-2
36. Ben-Porath I, Weinberg RA. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol. 2005;37:961-976. doi:10.1016/j.biocel.2004.10.013
37. Banito A, Rashid ST, Acosta JC, et al. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev. 2009;23:2134-2139. doi:10.1101/gad.1811609
38. Li Y, Zhang H, Xie M, et al. Abundant expression of Dec1/stra13/ sharp2 in colon carcinoma: its antagonizing role in serum deprivation- induced apoptosis and selective inhibition of procaspase activation. Biochem J. 2002;367(Pt 2):413-422. doi:10.1042/ BJ20020514
39. Seimiya M, Wada A, Kawamura K, et al. Impaired lymphocyte development and function in Clast5/Stra13/DEC1-transgenic mice. Eur J Immunol. 2004;34:1322-1332. doi:10.1002/eji.200324700
40. Qian Y, Zhang J, Yan B, Chen X. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem. 2008;283:2896-2905. doi:10.1074/jbc.M708624200