Molecular basis for the catalytic specificity of the CTX-M extended-spectrum β-lactamases

Biochemistry

Volumn 54, Issue 2, 2015, Pages 447-457

  Adamski, Carolyn J ^a   Cardenas, Ana Maria ^a   Brown, Nicholas G ^a   Horton, Lori B ^a   Sankaran, Banumathi ^b   Prasad, B V Venkataram ^a   Gilbert, Hiram F ^a   Palzkill, Timothy ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CRYSTAL STRUCTURE; DRUG PRODUCTS; ENZYMES; HEALTH RISKS;

ACTIVE SITE RESIDUES; ANTIBIOTIC-RESISTANT BACTERIA; CATALYTIC EFFICIENCIES; EXTENDED-SPECTRUM CEPHALOSPORINS; HIGH RESOLUTION CRYSTAL STRUCTURE; SITE DIRECTED MUTAGENESIS; SUBSTRATE PROFILE; WILD-TYPE ENZYMES;

HYDROLYSIS;

ARGININE; BETA LACTAMASE CTX M; BETA LACTAMASE TEM 1; CEFALOTIN; CEFOTAXIME; MUTANT PROTEIN; PENICILLIN G; PENICILLINASE; SERINE; ANTIINFECTIVE AGENT; BETA LACTAMASE; BETA-LACTAMASE CTX-M-14;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG CONFORMATION; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ESCHERICHIA COLI K 12; HYDROLYSIS; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; ANTIBIOTIC RESISTANCE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CEFOTAXIME; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED;

EID: 84922454033     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi501195g     Document Type: Article

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