Loss of autophagy causes a synthetic lethal deficiency in DNA repair

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 3, 2015, Pages 773-778

  Liu, Emma Y ^a   Xu, Naihan ^a,b   O'Prey, Jim ^a   Lao, Laurence Y ^a   Joshi, Sanket ^a   Long, Jaclyn S ^a   O'Prey, Margaret ^a   Croft, Daniel R ^a   Beaumatin, Florian ^a   Baudot, Alice D ^a   Mrschtik, Michaela ^a   Rosenfeldt, Mathias ^a   Zhang, Yaou ^b   Gillespie, David A ^a,c   Ryan, Kevin M ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b TSINGHUA UNIVERSITY   (China)

^c UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

Autophagy; Cell death; DNA repair; Synthetic lethality

Indexed keywords

CHECKPOINT KINASE 1; DOUBLE STRANDED DNA; PRIMER DNA;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL DEATH; COMPARATIVE STUDY; CYTOPLASM; DNA DAMAGE; DNA END JOINING REPAIR; DNA REPAIR; DNA STRAND; DNA SYNTHESIS; DOUBLE STRANDED DNA BREAK; EMBRYO; ENZYME PHOSPHORYLATION; FIBROBLAST; HOMOLOGOUS RECOMBINATION; IMMUNOFLUORESCENCE; LYSOSOME; MICRONUCLEUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNTHETIC LETHALITY; WESTERN BLOTTING; WILD TYPE; ANIMAL; CELL CULTURE; GENETICS; LETHAL GENE; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; AUTOPHAGY; BASE SEQUENCE; CELLS, CULTURED; DNA PRIMERS; DNA REPAIR; GENES, LETHAL; HOMOLOGOUS RECOMBINATION; MICE; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84922433890     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409563112     Document Type: Article

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