Associations between oxytocin receptor genotypes and social cognitive performance in individuals with schizophrenia

Schizophrenia Research

Volumn 159, Issue 2-3, 2014, Pages 353-357

  Davis, Michael C ^a,b   Horan, William P ^a,b   Nurmi, Erika L ^a   Rizzo, Shemra ^c   Li, Wendy ^a   Sugar, Catherine A ^a,c   Green, Michael F ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b and Clinical Center ^*  (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Oxytocin; Oxytocin receptor; Schizophrenia; Single nucleotide polymorphism; Social cognition

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; NEUROLEPTIC AGENT; OXYTOCIN RECEPTOR; THREONINE; OXTR PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; CLINICAL FEATURE; COGNITIVE DEFECT; CONTROLLED STUDY; EMOTIONAL INTELLIGENCE; EMOTIONALITY; FEMALE; FUNCTIONAL ASSESSMENT; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL CAPACITY; MENTAL PERFORMANCE; OUTPATIENT; PERCEPTION; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL BEHAVIOR; SOCIAL COGNITION; SYMPTOM; ADOLESCENT; ANALYSIS OF VARIANCE; COGNITION DISORDERS; COMPLICATION; GENETICS; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGICAL RATING SCALE; YOUNG ADULT;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; COGNITION DISORDERS; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; RECEPTORS, OXYTOCIN; SCHIZOPHRENIA; SOCIAL PERCEPTION; YOUNG ADULT;

EID: 84922421731     PISSN: 09209964     EISSN: 15732509     Source Type: Journal    
DOI: 10.1016/j.schres.2014.09.006     Document Type: Article

References (55)

1. Andreasen N.C. The Scale for the Assessment of Negative Symptoms (SANS) 1984, The University of Iowa, Iowa City, IA.
2. Bakermans-Kranenburg M.J., van IJzendoorn M.H. Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Soc. Cogn. Affect. Neurosci. 2008, 3(2):128-134.
3. Bakermans-Kranenburg M.J., van Ijzendoorn M.H. A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans. Psychiatr. Genet. 2014, 24(2):45-51.
4. Campbell D.B., Datta D., Jones S.T., Lee E.B., Sutcliffe J.S., Hammock E.A., Levitt P. Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder. J. Neurodev. Disord. 2011, 3(2):101-112.
5. Chang S.-C., Glymour M.M., Rewak M., Cornelis M.C., Walter S., Koenen K.C., Kawachi I., Liang L., Tchetgen Tchetgen E.J., Kubzansky L.D. Are genetic variations in OXTR, AVPR1A, and CD38 genes important to social integration? Results from two large US cohorts. Psychoneuroendocrinology 2014, 39:257-268.
6. Chen F.S., Kumsta R., von Dawans B., Monakhov M., Ebstein R.P., Heinrichs M. Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. Proc. Natl. Acad. Sci. 2011, 108(50):19937-19942.
7. Cohen J. Statistical Power Analysis for the Behavioral Sciences 1988, 567. L. Eribaum Associates, Hillsdale, NJ, (xxi).
8. 1000 Genomes Project Consortium An integrated map of genetic variation from 1,092 human genomes. Nature 2012, 491(7422):56-65.
9. Costa B., Pini S., Gabelloni P., Abelli M., Lari L., Cardini A., Muti M., Gesi C., Landi S., Galderisi S. Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology 2009, 34(10):1506-1514.
10. Damiano C.R., Aloi J., Dunlap K., Burrus C.J., Mosner M.G., Kozink R.V., McLaurin R.E., Carter R.M., Huettel S.A., McClernon F.J. Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards. Mol. Autism 2014, 5(1):7.
11. Ebstein R.P., Knafo A., Mankuta D., Chew S.H., Lai P.S. The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm. Behav. 2012, 61(3):359-379.
12. Feldman R., Zagoory-Sharon O., Weisman O., Schneiderman I., Gordon I., Maoz R., Shalev I., Ebstein R.P. Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes. Biol. Psychiatry 2012, 72(3):175-181.
13. Fett A.K., Viechtbauer W., Dominguez M.D., Penn D.L., van Os J., Krabbendam L. The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci. Biobehav. Rev. 2011, 35(3):573-588.
14. Green M.F., Hellemann G., Horan W.P., Lee J., Wynn J.K. From perception to functional outcome in schizophrenia: modeling the role of ability and motivation. Arch. Gen. Psychiatry 2012, 69(12):1216-1224.
15. Horan W.P., Green M.F., DeGroot M., Fiske A., Hellemann G., Kee K., Kern R.S., Lee J., Sergi M.J., Subotnik K.L., Sugar C.A., Ventura J., Nuechterlein K.H. Social cognition in schizophrenia, part 2: 12-month stability and prediction of functional outcome in first-episode patients. Schizophr. Bull. 2012, 38(4):865-872.
16. Hostinar C.E., Cicchetti D., Rogosch F.A. Oxytocin receptor gene polymorphism, perceived social support, and psychological symptoms in maltreated adolescents. Dev. Psychopathol. 2014, 26(02):465-477.
17. Israel S., Lerer E., Shalev I., Uzefovsky F., Riebold M., Laiba E., Bachner-Melman R., Maril A., Bornstein G., Knafo A. The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. PLoS One 2009, 4(5):e5535.
18. Jacob S., Brune C.W., Carter C., Leventhal B.L., Lord C., Cook E.H. Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. Neurosci. Lett. 2007, 417(1):6-9.
19. Kawamura Y., Liu X., Akiyama T., Shimada T., Otowa T., Sakai Y., Kakiuchi C., Umekage T., Sasaki T., Akiskal H.S. The association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments, as measured by TEMPS-A. J. Affect. Disord. 2010, 127(1):31-37.
20. Kim H.S., Sherman D.K., Sasaki J.Y., Xu J., Chu T.Q., Ryu C., Suh E.M., Graham K., Taylor S.E. Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proc. Natl. Acad. Sci. 2010, 107(36):15717-15721.
21. Kogan A., Saslow L.R., Impett E.A., Oveis C., Keltner D., Saturn S.R. Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition. Proc. Natl. Acad. Sci. 2011, 108(48):19189-19192.
22. Kumsta R., Heinrichs M. Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system. Curr. Opin. Neurobiol. 2013, 23(1):11-16.
23. Lerer E., Levi S., Salomon S., Darvasi A., Yirmiya N., Ebstein R. Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. Mol. Psychiatry 2007, 13(10):980-988.
24. Liu X., Kawamura Y., Shimada T., Otowa T., Koishi S., Sugiyama T., Nishida H., Hashimoto O., Nakagami R., Tochigi M. Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population. J. Hum. Genet. 2010, 55(3):137-141.
25. Lucht M.J., Barnow S., Sonnenfeld C., Rosenberger A., Grabe H.J., Schroeder W., Völzke H., Freyberger H.J., Herrmann F.H., Kroemer H. Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2009, 33(5):860-866.
26. MacDonald K., Feifel D. Oxytocin in schizophrenia: a review of evidence for its therapeutic effects. Acta Neuropsychiatr. 2012, 24(3):130-146.
27. Malik A.I., Zai C.C., Abu Z., Nowrouzi B., Beitchman J.H. The role of oxytocin and oxytocin receptor gene variants in childhood-onset aggression. Genes Brain Behav. 2012, 11(5):545-551.
28. Marsh A.A., Henry H.Y., Pine D.S., Gorodetsky E.K., Goldman D., Blair R. The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype. Psychopharmacology 2012, 224(4):469-476.
29. Mayer J.D., Salovey P., Caruso D.R., Sitarenios G. Measuring emotional intelligence with the MSCEIT V2.0. Emotion 2003, 3(1):97-105.
30. McDonald S., Flanagan S., Rollins J., Kinch J. TASIT: a new clinical tool for assessing social perception after traumatic brain injury. J. Head Trauma Rehabil. 2003, 18(3):219-238.
31. Meyer-Lindenberg A., Domes G., Kirsch P., Heinrichs M. Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat. Rev. Neurosci. 2011, 12(9):524-538.
32. Montag C., Brockmann E.-M., Bayerl M., Rujescu D., Müller D.J., Gallinat J. Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: a case-control study. World J. Biol. Psychiatry 2013, 14(7):500-508.
33. Montag C., Brockmann E.M., Bayerl M., Rujescu D., Muller D.J., Gallinat J. Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: a case-control study. World J. Biol. Psychiatry 2013, 14(7):500-508.
34. Montag C., Brockmann E.M., Lehmann A., Muller D.J., Rujescu D., Gallinat J. Association between oxytocin receptor gene polymorphisms and self-rated 'empathic concern' in schizophrenia. PLoS One 2012, 7(12):e51882.
35. Moons W.G., Way B.M., Taylor S.E. Oxytocin and Vasopressin Receptor Polymorphisms Interact With Circulating Neuropeptides to Predict Human Emotional Reactions to Stress 2014.
36. Park J., Willmott M., Vetuz G., Toye C., Kirley A., Hawi Z., Brookes K., Gill M., Kent L. Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2010, 34(4):697-702.
37. Rodrigues S.M., Saslow L.R., Garcia N., John O.P., Keltner D. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc. Natl. Acad. Sci. 2009, 106(50):21437-21441.
38. Rosenthal R., Hall J.A., DiMatteo M.R., Rogers P.L., Archer D. Sensitivity to Nonverbal Communication: The PONS Test 1979, Johns Hopkins University Press, Baltimore.
39. Ross H.E., Young L.J. Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior. Front. Neuroendocrinol. 2009, 30(4):534-547.
40. Saphire-Bernstein S., Way B.M., Kim H.S., Sherman D.K., Taylor S.E. Oxytocin receptor gene (OXTR) is related to psychological resources. Proc. Natl. Acad. Sci. 2011, 108(37):15118-15122.
41. Skuse D.H., Lori A., Cubells J.F., Lee I., Conneely K.N., Puura K., Lehtimäki T., Binder E.B., Young L.J. Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills. Proc. Natl. Acad. Sci. 2013, 201302985.
42. Smith K.E., Porges E.C., Norman G.J., Connelly J.J., Decety J. Oxytocin receptor gene variation predicts empathic concern and autonomic arousal while perceiving harm to others. Soc. Neurosci. 2014, 9(1):1-9.
43. Souza R.P., de Luca V., Meltzer H.Y., Lieberman J.A., Kennedy J.L. Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes. Int. J. Neuropsychopharmacol. 2010, 13(6):793-798.
44. Souza R.P., Ismail P., Meltzer H.Y., Kennedy J.L. Variants in the oxytocin gene and risk for schizophrenia. Schizophr. Res. 2010, 121(1-3):279-280.
45. Sturge-Apple M.L., Cicchetti D., Davies P.T., Suor J.H. Differential susceptibility in spillover between interparental conflict and maternal parenting practices: evidence for OXTR and 5-HTT genes. J. Fam. Psychol. 2012, 26(3):431.
46. Tabak B.A., McCullough M.E., Carver C.S., Pedersen E.J., Cuccaro M.L. Variation in oxytocin receptor gene (OXTR) polymorphisms is associated with emotional and behavioral reactions to betrayal. Soc. Cogn. Affect. Neurosci. 2013, nst042.
47. Thompson R.J., Parker K.J., Hallmayer J.F., Waugh C.E., Gotlib I.H. Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. Psychoneuroendocrinology 2011, 36(1):144-147.
48. Tops M., Van IJzendoorn M.H., Riem M.M., Boksem M.A., Bakermans-Kranenburg M.J. Oxytocin receptor gene associated with the efficiency of social auditory processing. Front. Psychiatry 2011, 2.
49. Tost H., Kolachana B., Hakimi S., Lemaitre H., Verchinski B.A., Mattay V.S., Weinberger D.R., Meyer-Lindenberg A. A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proc. Natl. Acad. Sci. 2010, 107(31):13936-13941.
50. Ventura J., Lukoff D., Nuechterlein K.H., Liberman R.L., Green M.F., Shaner A. Brief Psychiatric Rating Scale (BPRS). Int. J. Methods Psychiatr. Res. 1993, 3:227-243.
51. Walum H., Lichtenstein P., Neiderhiser J.M., Reiss D., Ganiban J.M., Spotts E.L., Pedersen N.L., Anckarsäter H., Larsson H., Westberg L. Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior. Biol. Psychiatry 2012, 71(5):419-426.
52. Ward L.D., Kellis M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 2012, 40(Database issue):D930-934.
53. Watanabe Y., Kaneko N., Nunokawa A., Shibuya M., Egawa J., Someya T. Oxytocin receptor (OXTR) gene and risk of schizophrenia: case-control and family-based analyses and meta-analysis in a Japanese population. Psychiatry Clin. Neurosci. 2012, 66(7):622.
54. Wu N., Li Z., Su Y. The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. J. Affect. Disord. 2012, 138(3):468-472.
55. Wu S., Jia M., Ruan Y., Liu J., Guo Y., Shuang M., Gong X., Zhang Y., Yang X., Zhang D. Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol. Psychiatry 2005, 58(1):74-77.