The influence of oxytocin administration on responses to infant faces and potential moderation by OXTR genotype

Psychopharmacology

Volumn 224, Issue 4, 2012, Pages 469-476

  Marsh, Abigail A ^a,b   Yu, Henry H ^b   Pine, Daniel S ^b   Gorodetsky, Elena K ^c   Goldman, David ^c   Blair, R J R ^b  

^a GEORGETOWN UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Affiliation; Faces; OXTR; Oxytocin; Parental

Indexed keywords

OXYTOCIN; OXYTOCIN RECEPTOR; PLACEBO;

ADULT; ALLELE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FACE; FEMALE; GENOTYPE; HOMOZYGOTE; HUMAN; HUMAN EXPERIMENT; INFANT FACE; MALE; NORMAL HUMAN; OXTR GENE; PERCEPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STIMULUS RESPONSE;

ADMINISTRATION, INTRANASAL; ADOLESCENT; ADULT; CHOICE BEHAVIOR; DOUBLE-BLIND METHOD; FACE; FEMALE; GENOTYPE; HUMANS; MALE; OXYTOCIN; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OXYTOCIN; REWARD; YOUNG ADULT;

EID: 84871618620     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2775-0     Document Type: Article

References (54)

1. Bakermans-Kranenburg MJ, Van Ijzendoorn MH (2008) Oxytocin receptor (oxtr) and serotonin transporter (5-htt) genes associated with observed parenting. Soc Cogn Affect Neurosci 3:128-134. doi: 10.1093/scan/nsn004
2. Bartz J, Zaki J, Bolger N, Hollander E, Ludwig N, Kolevzon A, Ochsner K (2010) Oxytocin selectively improves empathic accuracy. Psychol Sci 21:1426-1428. doi: 10.1177/0956797610383439
3. Bartz J, Simeon D, Hamilton H, Kim S, Crystal S, Braun A, Vicens V, Hollander E (2011) Oxytocin can hinder trust and cooperation in borderline personality disorder. Soc Cogn Affect Neurosci 6:556-563. doi: 10.1093/scan/nsq085
4. Baumgartner T, Heinrichs M, Vonlanthen A, Fischbacher U, Fehr E (2008) Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron 58:639-650. doi: 10.1016/j.neuron.2008.04.009
5. Carter CS (1998) Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology 23:779-818. doi: 10.1016/S0306-4530(98)00055-9
6. Carter CS, Altemus M (1997) Integrative functions of lactational hormones in social behavior and stress management. Ann N Y Acad Sci 807:164-174. doi: 10.1111/j.1749-6632.1997.tb51918.x
7. Champagne F, Diorio J, Sharma S, Meaney MJ (2001) Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors. Proc Natl Acad Sci 98:12736-12741. doi: 10.1073/pnas.221224598
8. Chen F, Barth M, Johnson S, Gotlib I, Johnson S (2011) Oxytocin receptor (OXTR) polymorphisms and attachment in human infants. Front Psychol 2:200. doi: 10.3389/fpsyg.2011.00200
9. Costa B, Pini S, Gabelloni P, Abelli M, Lari L, Cardini A, Muti M, Gesi C, Landi S, Galderisi S, Mucci A, Lucacchini A, Cassano G, Martini C (2009) Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology 34:1506-1514. doi: 10.1016/j.psyneuen.2009. 05.006
10. De Dreu CK (2012) Oxytocin modulates cooperation within and competition between groups: an integrative review and research agenda. Horm Behav 61:419-428. doi: 10.1016/j.yhbeh.2011.12.009
11. De Waal FB (2008) Putting the altruism back into altruism: the evolution of empathy. Annu Rev Psychol 59:279-300. doi: 10.1146/annurev.psych.59.103006. 093625
12. Ebstein RP, Israel S, Chew SH, Zhong S, Knafo A (2010) Genetics of human social behavior. Neuron 65(6):831-844. doi: 10.1016/j.neuron.2010.02.020
13. Eibl-Eibesfeldt I (1996) Love and hate: the natural history of behavior patterns. Aldine, Venice
14. Feldman R, Weller A, Zagoory-Sharon O, Levine A (2007) Evidence for a neuroendocrinological foundation of human affiliation: plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychol Sci 18:965-970. doi: 10.1111/j.1467-9280.2007.02010.x
15. Fewtrell M, Loh K, Blake A, Ridout D, Hawdon J (2006) Randomised, double blind trial of oxytocin nasal spray in mothers expressing breast milk for preterm infants. Arch Dis Child Fetal Neonatal Ed 91:F169-74. doi: 10.1136/adc.2005.081265
16. Fleming A, Vaccarino F, Luebke C (1980) Amygdaloid inhibition of maternal behavior in the nulliparous female rat. Physiol Behav 25:731-743
17. Forsling ML (1986) Regulation of oxytocin release. In: Gantner D, Pfaff D (eds) Current topics in neuroendocrinology, vol. 6, neurobiology of oxytocin. Springer, Berlin
18. Francis DD, Champagne FC, Meaney MJ (2000) Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat. J Neuroendocrinol 12:1145-1148. doi: 10.1046/j.1365-2826.2000.00599.x
19. Francis DD, Young LJ, Meaney MJ, Insel TR (2002) Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin (v1a) receptors: gender differences. J Neuroendocrinol 14:349-353. doi: 10.1046/j.0007-1331.2002.00776.x
20. Grosvenor CE, Shah GV, Crowley WR (1990) Role of neurogenic stimuli and milk production in the regulation of prolactin secretion during lactation. In: Krasnegor NA, Bridges RS (eds) Mammalian parenting: biochemical, neurobiological, and behavioral determinants. Oxford University Press, New York, pp 324-342
21. Guastella A, Kemp A (2011) The role of oxytocin in human affect: a novel hypothesis. Curr Dir Psychol Sci 20:222-231. doi: 10.1177/0963721411417547
22. Heekeren HR, Wartenburger I, Schmidt H, Prehn K, Schwintowski HP, Villringer A (2005) Influence of bodily harm on neural correlates of semantic and moral decision-making. Neuroimage 24:887-897. doi: 10.1016/j.neuroimage. 2004.09.026
23. Insel TR (1992) Oxytocin - a neuropeptide for affiliation: evidence from behavioral, receptor autoradiographic, and comparative studies. Psychoneuroendocrinology 17:3-35. doi: 10.1016/0306-4530(92)90073-G
24. Insel TR (2010) The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior. Neuron 65(6):768-779. doi: 10.1016/j.neuron.2010.03.005
25. Kendrick KM (1997) Neural control of maternal behaviour and olfactory recognition of offspring. Brain Res Bull 44:383-395. doi: 10.1016/S0361-9230(97) 00218-9
26. Kendrick KM, Keverne EB, Baldwin BA (1987) Intracerebroventricular oxytocin stimulates maternal behaviour in the sheep. Neuroendocrinology 46:56-61. doi: 10.1159/000124796
27. Kogan A, Saslow L, Impett E, Oveis C, Keltner D, Rodrigues Saturn S (2011) Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition. Proc Natl Acad Sci U S A 108:19189-19192. doi: 10.1073/pnas.1112658108
28. Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E (2005) Oxytocin increases trust in humans. Nature 435:673-676. doi: 10.1038/nature03701
29. Labuschagne I, Phan K, Wood A, Angstadt M, Chua P, Heinrichs M, Stout J, Nathan P (2010) Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology 35:2403-2413. doi: 10.1038/npp.2010.123
30. Leng G, Meddle S, Douglas A (2008) Oxytocin and the maternal brain. Curr Opin Pharmacol 8:731-734. doi: 10.1016/j.coph.2008.07.001
31. Madden JR, Clutton-Brock TH (2011) Experimental peripheral administration of oxytocin elevates a suite of cooperative behaviours in a wild social mammal. Proc Biol Sci 278:1189-1194. doi: 10.1098/rspb.2010.1675
32. Marsh AA, Yu HH, Schechter JC, Blair RJR (2009) Larger than life: humans' nonverbal status cues alter perceived size. PLoS One 4:e5707. doi: 10.1371/journal.pone.0005707
33. Marsh AA, Yu HH, Pine D, Blair R (2010) Oxytocin improves specific recognition of positive facial expressions. Psychopharmacology 209:225-232. doi: 10.1007/s00213-010-1780-4
34. Naber F, Van Ijzendoorn MH, Deschamps P, Van Engeland H, Bakermans-Kranenburg MJ (2010) Intranasal oxytocin increases fathers' observed responsiveness during play with their children: a double-blind within-subject experiment. Psychoneuroendocrinology 35:1583-1586. doi: 10.1016/j.psyneuen.2010. 04.007
35. Pedersen CA (2004) Biological aspects of social bonding and the roots of human violence. Ann N Y Acad Sci 1036:106-127. doi: 10.1196/annals.1330.006
36. Pedersen CA, Ascher JA, Monroe YL, Prange AJJ (1982) Oxytocin induces maternal behavior in virgin female rats. Science 216:648-650
37. Pedersen CA, Caldwell JD, Peterson G, Walker CH, Mason GA (1992) Oxytocin activation of maternal behavior in the rat. Ann N Y Acad Sci 652:58-69. doi: 10.1111/j.1749-6632.1992.tb34346.x
38. Razzoli M, Cushing B, Carter C, Valsecchi P (2003) Hormonal regulation of agonistic and affiliative behavior in female Mongolian gerbils (Meriones unguiculatus). Horm Behav 43:549-553. doi: 10.1016/S0018-506X(03)00064-3
39. Riem M, Bakermans-Kranenburg MJ, Pieper S, Tops M, Boksem M, Vermeiren R, Van Ijzendoorn MH, Rombouts S (2011) Oxytocin modulates amygdala, insula, and inferior frontal gyrus responses to infant crying: a randomized controlled trial. Biol Psychiatry 70:291-297. doi: 10.1016/j.biopsych.2011.02.006
40. Rockliff H, Karl A, McEwan K, Gilbert J, Matos M, Gilbert P (2011) Effects of intranasal oxytocin on compassion focused imagery. Emotion 11: 1388-1396. doi: 10.1037/a0023861
41. Rodrigues S, Saslow L, Garcia N, John O, Keltner D (2009) Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc Natl Acad Sci U S A 106:21437-21441. doi: 10.1073/pnas.0909579106
42. Ross H, Freeman S, Spiegel L, Ren X, Terwilliger E, Young L (2009) Variation in oxytocin receptor density in the nucleus accumbens has differential effects on affiliative behaviors in monogamous and polygamous voles. J Neurosci 29:1312-1318. doi: 10.1523/JNEUROSCI.5039-08.2009
43. Shamay-Tsoory SG, Fischer M, Dvash J, Harari H, Perach-Bloom N, Levkovitz Y (2009) Intranasal administration of oxytocin increases envy and schadenfreude (gloating). Biol Psychiatry 66:864-870. doi: 10.1016/j.biopsych.2009.06.009
44. Strathearn L, Fonagy P, Amico J, Montague P (2009) Adult attachment predicts maternal brain and oxytocin response to infant cues. Neuropsychopharmacology 34:2655-2666. doi: 10.1038/npp.2009.103
45. Swain J, Tasgin E, Mayes LC, Feldman R, Todd Constable R, Leckman J (2008) Maternal brain response to own baby-cry is affected by cesarean section delivery. J Child Psychol Psychiatry 49:1042-1052. doi: 10.1111/j.1469-7610. 2008.01963.x
46. Tansey KE, Brookes K, Hill M, Cochrane L, Gill M, Skuse D, Correia C, Vicente A, Kent L, Gallagher L, Anney R (2010) Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: genetic and molecular studies. Neurosci Lett 474:163-167. doi: 10.1016/j.neulet.2010.03.035
47. Tops M, Van Ijzendoorn MH, Riem M, Boksem M, Bakermans-Kranenburg MJ (2011) Oxytocin receptor gene associated with the efficiency of social auditory processing. Front Psychiatry 2:60. doi: 10.3389/fpsyt.2011.00060
48. Tost H, Kolachana B, Hakimi S, Lemaitre H, Verchinski B, Mattay V, Weinberger D, Meyer-Lindenberg A (2010) A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proc Natl Acad Sci U S A 107:13936-13941. doi: 10.1073/pnas.1003296107
49. Toth A, Varala K, Newman T, Miguez F, Hutchison S, Willoughby D, Simons J, Egholm M, Hunt J, Hudson M, Robinson G (2007) Wasp gene expression supports an evolutionary link between maternal behavior and eusociality. Science 318:441-444. doi: 10.1126/science.1146647
50. Wechsler D (1999) Wechsler abbreviated scale of intelligence. Psychological Corporation, San Antonio
51. Wu S, Jia M, Ruan Y, Liu J, Guo Y, Shuang M, Gong X, Zhang Y, Yang X, Zhang D (2005) Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol Psychiatry 58:74-77. doi: 10.1016/j.biopsych.2005.03.013
52. Young LJ, Lim MM, Gingrich B, Insel TR (2001) Cellular mechanisms of social attachment. Horm Behav 40:133-138. doi: 10.1006/hbeh.2001.1691
53. Zak P, Stanton A, Ahmadi S (2007) Oxytocin increases generosity in humans. PLoS One 2:e1128. doi: 10.1371/journal.pone.0001128
54. Zebrowitz LA, Luevano VX, Bronstad PM, Aharon I (2009) Neural activation to babyfaced men matches activation to babies. Soc Neurosci 4:1-10. doi: 10.1080/17470910701676236