Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 34, Issue 4, 2010, Pages 697-702

  Park, J ^a   Willmott, M ^a   Vetuz, G ^a   Toye, C ^a   Kirley, A ^b   Hawi, Z ^b   Brookes, K J ^a   Gill, M ^b   Kent, L ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b ST JAMES S HOSPITAL   (Ireland)

Author keywords

ADHD; Association; Human post mortem brain tissue; OXTR; Social cognition

Indexed keywords

MESSENGER RNA; OXYTOCIN RECEPTOR;

ADOLESCENT; ADULT; AGED; AMYGDALOID NUCLEUS; ARTICLE; ATTENTION DEFICIT DISORDER; BEHAVIOR GENETICS; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL BEHAVIOR;

ADOLESCENT; ADULT; AGED; ALLELES; AMYGDALA; ANALYSIS OF VARIANCE; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OXYTOCIN; SOCIAL BEHAVIOR; SOCIAL PERCEPTION;

EID: 77952674475     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2010.03.029     Document Type: Article

References (46)

1. Adolphs R. Recognizing emotion from facial expressions: psychological and neurological mechanisms. Behav Cogn Neurosci Rev 2002, 1:21-62.
2. Andari E., Duhamel J.R., Zalla T., Herbrecht E., Leboyer M., Sirigu A. Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc Natl Acad Sci 2010, 107(9):4389-4394.
3. Angold A., Prendergast M., Cox A., Harrington R., Simonoff E., Rutter M. The Child and Adolescent Psychiatric Assessment (CAPA). Psychol Med 1995, 25:739-753.
4. Asherson P. Attention-Deficit Hyperactivity Disorder in the post-genomic era. Eur Child Adolesc Psychiatry 2004, 13(Suppl 1):I50-I70.
5. Bakermans-Kranenburg M.J., van Ijzendoorn M.H. Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Soc Cogn Affect Neurosci 2008, 3:128-134.
6. Bale T.L., Davis A.M., Auger A.P., Dorsa D.M., McCarthy M.M. CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. J Neurosci 2001, 21:2546-2552.
7. Bahn S., Augood S.J., Ryan M., Standaert D.G., Starkey M., Emson P.C. Gene expression profiling in the post-mortem human brain - no cause for dismay. J Chem Neuroanat 2001, 22:79-94.
8. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
9. Conners C.K. The Conners Rating Scale: Instruments for the Assessments of Childhood Psychopathology 1995, Duke University.
10. Davis M., Whalen P.J. The amygdala: vigilance and emotion. Mol Psychiatry 2001, 6:13-34.
11. Domes G., Heinrichs M., Glascher J., Buchel C., Braus D.F., Herpertz S.C. Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biol Psychiatry 2007, 62:1187-1190.
12. Domes G., Heinrichs M., Michel A., Berger C., Herpertz S.C. Oxytocin improves "mind-reading" in humans. Biol Psychiatry 2007, 61:731-733.
13. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003, 25:115-121.
14. Freeman B., Smith N., Curtis C., Huckett L., Mill J., Craig I.W. DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping. Behav Genet 2003, 33:67-72.
15. Gregory S.G., Connelly J.J., Towers A.J., Johnson J., Biscocho D., Markunas C.A., et al. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med 2009, 7:62.
16. Guastella A.J., Einfeld S.L., Gray K.M., Rinehart N.J., Tonge B.J., Lambert T.J., et al. Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biol Psychiatry 2009, 67(7):692-694.
17. Guastella A.J., Mitchell P.B., Dadds M.R. Oxytocin increases gaze to the eye region of human faces. Biol Psychiatry 2008, 63:3-5.
18. Harrison P.J., Heath P.R., Eastwood S.L., Burnet P.W.J., McDonald B., Pearson R.C.A. The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins. Neurosci Lett 1995, 200:151-154.
19. Hattori J., Ogino T., Abiru K., Nakano K., Oka M., Ohtsuka Y. Are pervasive developmental disorders and attention-deficit/hyperactivity disorder distinct disorders?. Brain Dev 2006, 28:371-374.
20. Hollander E., Bartz J., Chaplin W., Phillips A., Sumner J., Soorya L., et al. Oxytocin increases retention of social cognition in autism. Biol Psychiatry 2007, 61:498-503.
21. Huber D., Veinante P., Stoop R. Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 2005, 308:245-248.
22. Jacob S., Brune C.W., Carter C.S., Leventhal B.L., Lord C., Cook E.H. Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. Neurosci Lett 2007, 417:6-9.
23. Kaufman J., Birmaher B., Brent D., Rao U., Flynn C., Moreci P., et al. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997, 36:980-988.
24. Keverne E.B., Curley J.P. Vasopressin, oxytocin and social behaviour. Curr Opin Neurobiol 2004, 14:777-783.
25. Kimura T., Saji F., Nishimori K., Ogita K., Nakamura H., Koyama M., et al. Molecular regulation of the oxytocin receptor in peripheral organs. J Mol Endocrinol 2003, 30:109-115.
26. Kusui C., Kimura T., Ogita K., Nakamura H., Matsumura Y., Koyama M., et al. DNA methylation of the human oxytocin receptor gene promoter regulates tissue-specific gene suppression. Biochem Biophys Res Commun 2001, 289:681-686.
27. Landgraf R., Neumann I.D. Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Front Neuroendocrinol 2004, 25:150-176.
28. Lauritsen M.B., Als T.D., Dahl H.A., Flint T.J., Wang A.G., Vang M., et al. A genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the Faroe Islands. Mol Psychiatry 2006, 11:37-46.
29. Lee H.J., Caldwell H.K., Macbeth A.H., Tolu S.G., Young W.S. A conditional knockout mouse line of the oxytocin receptor. Endocrinology 2008, 149:3256-3263.
30. Lerer E., Levi S., Salomon S., Darvasi A., Yirmiya N., Ebstein R.P. Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. Mol Psychiatry 2007, 13:980-988.
31. Liu X., Kawamura Y., Shimada T., Otowa T., Koishi S., Sugiyama T., et al. Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population. J Hum Genet 2010, 10.1038/jhg.2009.140.
32. McCauley J.L., Li C., Jiang L., Olson L.M., Crockett G., Gainer K., et al. Genome-wide and ordered-subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates. BMC Med Genet 2005, 6:1.
33. Mizumoto Y., Kimura T., Ivell R. A genomic element within the third intron of the human oxytocin receptor gene may be involved in transcriptional suppression. Mol Cell Endocrinol 1997, 135:129-138.
34. Modahl C., Green L., Fein D., Morris M., Waterhouse L., Feinstein C., et al. Plasma oxytocin levels in autistic children. Biol Psychiatry 1998, 43:270-277.
35. Mulligan A., Anney R.J., O'Regan M., Chen W., Butler L., Fitzgerald M., et al. Autism symptoms in Attention-Deficit/Hyperactivity Disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders. J Autism Dev Disord 2009, 39:197-209.
36. Pelham WE, Bender ME. Peer relationships in hyperactive children: Description and treatment. In: Gadow KD, Bialer I, editors. Advances in learning and behavioural disabilities, vol. 1. Greenwich, Conn: JA1 Press; 1982. pp. 365-436.
37. Polanczyk G., Rohde L.A. Epidemiology of attention-deficit/hyperactivity disorder across the lifespan. Curr Opin Psychiatry 2007, 20:386-392.
38. Reiersen A.M., Constantino J.N., Volk H.E., Todd R.D. Autistic traits in a population-based ADHD twin sample. J Child Psychol Psychiatry 2007, 48:464-472.
39. Rodrigues S.M., Saslow L.R., Garcia N., John O.P., Keltner D. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. PNAS 2009, 106:21437-21441.
40. Ronald A., Simonoff E., Kuntsi J., Asherson P., Plomin R. Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample. J Child Psychol Psychiatry 2008, 49:535-542.
41. Santosh P.J., Mijovic A. Social impairment in Hyperkinetic Disorder - relationship to psychopathology and environmental stressors. Eur Child Adolesc Psychiatry 2004, 13:141-150.
42. Skuse D.H., Mandy W.P., Scourfield J. Measuring autistic traits: heritability, reliability and validity of the Social and Communication Disorders Checklist. Br J Psychiatry 2005, 187:568-572.
43. Veinante P., Freund-Mercier M.J. Distribution of oxytocin- and vasopressin-binding sites in the rat extended amygdala: a histoautoradiographic study. J Comp Neurol 1997, 383:305-325.
44. Wermter A.K., Kamp-Becker I., Hesse P., Schulte-Körne G., Strauch K., Remschmidt H. Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level. Am J Med Genet B Neuropsychiatr Genet 2010, 153B(2):629-639.
45. Winslow J.T., Insel T.R. The social deficits of the oxytocin knockout mouse. Neuropeptides 2002, 36:221-229.
46. Wu S., Jia M., Ruan Y., Liu J., Guo Y., Shuang M., et al. Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol Psychiatry 2005, 58:74-77.