Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards

Molecular Autism

Volumn 5, Issue 1, 2014, Pages

  Damiano, Cara R ^a   Aloi, Joseph ^a   Dunlap, Kaitlyn ^b   Burrus, Caley J ^b   Mosner, Maya G ^a   Kozink, Rachel V ^c   McLaurin, Ralph Edward ^c   Mullette Gillman, O'Dhaniel A ^d,e   Carter, Ronald McKell ^b,c   Huettel, Scott A ^b,c   McClernon, Francis Joseph ^c   Ashley Koch, Allison ^c   Dichter, Gabriel S ^a,b,f  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b DUKE UNIVERSITY   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Autism spectrum disorder (ASD); Functional magnetic resonance imaging (fMRI); Genetics; Mesolimbic; Motivation; Neuroimaging; Oxytocin; Oxytocin receptor; Reward; Single nucleotide polymorphism (SNP)

Indexed keywords

EID: 84893169738     PISSN: None     EISSN: 20402392     Source Type: Journal    
DOI: 10.1186/2040-2392-5-7     Document Type: Article

References (105)

1. Advances in autism genetics: on the threshold of a new neurobiology. Abrahams BS, Geschwind DH, Nat Rev Genet 2008 9 341 355 10.1038/nrg2346 18414403 (Pubitemid 351556064)
2. Genetics of autism spectrum disorders. Geschwind DH, Trends Cogn Sci 2011 15 409 416 10.1016/j.tics.2011.07.003 21855394
3. The conundrums of understanding genetic risks for autism spectrum disorders. State MW, Levitt P, Nat Neurosci 2011 14 1499 1506 10.1038/nn.2924 22037497
4. Autism-associated promoter variant in MET impacts functional and structural brain networks. Rudie JD, Hernandez LM, Brown JA, Beck-Pancer D, Colich NL, Gorrindo P, Thompson PM, Geschwind DH, Bookheimer SY, Levitt P, Dapretto M, Neuron 2012 75 904 915 10.1016/j.neuron.2012.07.010 22958829
5. Imaging genetics. Munoz KE, Hyde LW, Hariri AR, J Am Acad Child Adolesc Psychiatr 2009 48 356 361 10.1097/CHI.0b013e31819aad07
6. Optimizing the phenotyping of rodent ASD models: enrichment analysis of mouse and human neurobiological phenotypes associated with high-risk autism genes identifies morphological, electrophysiological, neurological, and behavioral features. Buxbaum JD, Betancur C, Bozdagi O, Dorr NP, Elder GA, Hof PR, Mol Autism 2012 3 1 8 10.1186/2040-2392-3-1 22348382
7. A genome-wide linkage and association scan reveals novel loci for autism. Weiss LA, Arking DE, Daly MJ, Chakravarti A, Nature 2009 461 802 808 10.1038/nature08490 19812673
8. A genome-wide scan for common alleles affecting risk for autism. Anney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Sykes N, Pagnamenta AT, Hum Mol Genet 2010 19 4072 4082 10.1093/hmg/ddq307 20663923
9. Genes controlling affiliative behavior as candidate genes for autism. Yrigollen CM, Han SS, Kochetkova A, Babitz T, Chang JT, Volkmar FR, Leckman JF, Grigorenko EL, Biol Psychiatry 2008 63 911 916 10.1016/j.biopsych.2007.11.015 18207134
10. Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder. Campbell DB, Datta D, Jones ST, Batey Lee E, Sutcliffe JS, Hammock EAD, Levitt P, J Neurodev Disord 2011 3 101 112 10.1007/s11689-010-9071-2 21484202
11. Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families. Ylisaukkooja T, Alarcón M, Cantor RM, Auranen M, Vanhala R, Kempas E, von Wendt L, Järvelä I, Geschwind DH, Peltonen L, Ann Neurol 2006 59 145 155 10.1002/ana.20722 16288458 (Pubitemid 43042881)
12. Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Wu S, Jia M, Ruan Y, Liu J, Guo Y, Shuang M, Gong X, Zhang Y, Yang X, Zhang D, Biol Psychiatry 2005 58 74 77 10.1016/j.biopsych. 2005.03.013 15992526 (Pubitemid 40909939)
13. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. Gregory S, Connelly J, Towers A, Johnson J, Biscocho D, Markunas C, Lintas C, Abramson R, Wright H, Ellis P, BMC Med 2009 7 62 10.1186/1741-7015-7- 62 19845972
14. A gender-specific mechanism for pair bonding: oxytocin and partner preference formation in monogamous voles. Insel TR, Hulihan TJ, Behav Neurosci 1995 109 782 789 7576222
15. Oxytocin improves 'mind-reading' in humans. Domes G, Heinrichs M, Michel A, Berger C, Herpertz SC, Biol Psychiatry 2007 61 731 733 10.1016/j.biopsych. 2006.07.015 17137561 (Pubitemid 46330242)
16. Oxytocin increases gaze to the eye region of human faces. Guastella AJ, Mitchell PB, Dadds MR, Biol Psychiatry 2008 63 3 5 10.1016/j.biopsych.2007.06. 026 17888410 (Pubitemid 350234895)
17. Oxytocin receptor (OXTR) polymorphisms and attachment in human infants. Chen FS, Barth ME, Johnson SL, Gotlib IH, Johnson SC, Front Psychol 2011 2 1 6 21713130
18. The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior. Insel TR, Neuron 2010 65 768 779 10.1016/j.neuron.2010.03.005 20346754
19. Plasma oxytocin levels in autistic children. Modahl C, Green LA, Fein D, Morris M, Waterhouse L, Feinstein C, Levin H, Biol Psychiatry 1998 43 270 277 10.1016/S0006-3223(97)00439-3 9513736 (Pubitemid 28085673)
20. Oxytocin and autistic disorder: alterations in peptide forms. Green LA, Fein D, Modahl C, Feinstein C, Waterhouse L, Morris M, Biol Psychiatry 2001 50 609 613 10.1016/S0006-3223(01)01139-8 11690596 (Pubitemid 33022646)
21. Oxytocin increases retention of social cognition in autism. Hollander E, Bartz J, Chaplin W, Phillips A, Sumner J, Soorya L, Anagnostou E, Wasserman S, Biol Psychiatry 2007 61 498 503 10.1016/j.biopsych.2006.05.030 16904652 (Pubitemid 46185336)
22. Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Andari E, Duhamel JR, Zalla T, Herbrecht E, Leboyer M, Sirigu A, Proc Natl Acad Sci 2010 107 4389 4394 10.1073/pnas.0910249107 20160081
23. Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Guastella AJ, Einfeld SL, Gray KM, Rinehart NJ, Tonge BJ, Lambert TJ, Hickie IB, Biol Psychiatry 2010 67 692 694 10.1016/j.biopsych.2009. 09.020 19897177
24. Oxytocin: prosocial behavior, social salience, or approach-related behavior? Kemp AH, Guastella AJ, Biol Psychiatry 2010 67 33 34 10.1016/j.biopsych.2009.11.019
25. Is social attachment an addictive disorder? Insel TR, Physiol Behav 2003 79 351 357 10.1016/S0031-9384(03)00148-3 12954430 (Pubitemid 37087904)
26. Understanding the nature of face processing impairment in autism: insights from behavioral and electrophysiological studies. Dawson G, Webb SJ, McPartland J, Dev Neuropsychol 2005 27 403 424 10.1207/s15326942dn2703-6 15843104 (Pubitemid 40712809)
27. The social motivation theory of autism. Chevallier C, Kohls G, Troiani V, Brodkin ES, Schultz RT, Trends Cogn Sci 2012 16 231 239 10.1016/j.tics.2012.02. 007 22425667
28. Reward processing in autism. Scott-Van Zeeland AA, Dapretto M, Ghahremani DG, Poldrack RA, Bookheimer SY, Autism Res 2010 3 53 67 20437601
29. Reward circuitry function in autism during face anticipation and outcomes. Dichter GS, Richey JA, Rittenberg AM, Sabatino A, Bodfish JW, J Autism Dev Disord 2012 42 147 160 10.1007/s10803-011-1221-1 22187105
30. Reward circuitry function in autism spectrum disorders. Dichter GS, Felder JN, Green SR, Rittenberg AM, Sasson NJ, Bodfish JW, Soc Cogn Affect Neurosci 2012 7 160 172 10.1093/scan/nsq095 21148176
31. Response of neural reward regions to food cues in autism spectrum disorders. Cascio CJ, Foss-Feig JH, Heacock JL, Newsom CR, Cowan RL, Benningfield MM, Rogers BP, Cao A, J Neurodev Disord 2012 4 9 10.1186/1866-1955-4-9 22958533
32. Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles. Insel TR, Shapiro LE, Proc Natl Acad Sci 1992 89 5981 5985 10.1073/pnas.89.13.5981 1321430
33. Distribution of vasopressin and oxytocin binding sites in the brain and upper spinal cord of the common marmoset. Schorscher-Petcu A, Dupré A, Tribollet E, Neurosci Lett 2009 461 217 222 10.1016/j.neulet.2009.06.016 19539696
34. Variation in oxytocin receptor density in the nucleus accumbens has differential effects on affiliative behaviors in monogamous and polygamous voles. Ross HE, Freeman SM, Spiegel LL, Ren X, Terwilliger EF, Young LJ, J Neurosci 2009 29 1312 1318 10.1523/JNEUROSCI.5039-08.2009 19193878
35. The neuroendocrine basis of social recognition. Ferguson JN, Young LJ, Insel TR, Front Neuroendocrinol 2002 23 200 224 10.1006/frne.2002.0229 11950245 (Pubitemid 34309926)
36. Species and individual differences in juvenile female alloparental care are associated with oxytocin receptor density in the striatum and the lateral septum. Olazabal DE, Young LJ, Horm Behav 2006 49 681 687 10.1016/j.yhbeh.2005. 12.010 16442534
37. Oxytocin receptors in the nucleus accumbens facilitate 'spontaneous' maternal behavior in adult female prairie voles. Olazabal DE, Young LJ, Neuroscience 2006 141 559 568 10.1016/j.neuroscience.2006.04.017 16725274 (Pubitemid 44066664)
38. Oxytocin in the medial amygdala is essential for social recognition in the mouse. Ferguson JN, Aldag JM, Insel TR, Young LJ, J Neurosci 2001 21 8278 8285 11588199 (Pubitemid 32952782)
39. Characterization of the oxytocin system regulating affiliative behavior in female prairie voles. Ross HE, Cole CD, Smith Y, Neumann ID, Landgraf R, Murphy AZ, Young LJ, Neuroscience 2009 162 892 903 10.1016/j.neuroscience.2009. 05.055 19482070
40. Oxytocin injected into the ventral tegmental area induces penile erection and increases extracellular dopamine in the nucleus accumbens and paraventricular nucleus of the hypothalamus of male rats. Melis MR, Melis T, Cocco C, Succu S, Sanna F, Pillolla G, Boi A, Ferri GL, Argiolas A, Eur J Neurosci 2007 26 1026 1035 10.1111/j.1460-9568.2007.05721.x 17672853 (Pubitemid 47274616)
41. Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat. Shahrokh DK, Zhang T-Y, Diorio J, Gratton A, Meaney MJ, Endocrinology 2010 151 2276 2286 10.1210/en.2009-1271 20228171
42. Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areas. Pedersen CA, Caldwell JD, Walker C, Ayers G, Mason GA, Behav Neurosci 1994 108 1163 1171 7893408
43. Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles. Liu Y, Wang ZX, Neuroscience 2003 121 537 544 10.1016/S0306-4522(03)00555-4 14568015 (Pubitemid 38367494)
44. Oxytocin influences processing of socially relevant cues in the ventral tegmental area of the human brain. Groppe SE, Gossen A, Rademacher L, Hahn A, Westphal L, Gründer G, Spreckelmeyer KN, Biol Psychiatry 2013 74 172 179 10.1016/j.biopsych.2012.12.023 23419544
45. Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men. Rilling JK, DeMarco AC, Hackett PD, Thompson R, Ditzen B, Patel R, Pagnoni G, Psychoneuroendocrinology 2012 37 447 461 10.1016/j.psyneuen.2011.07.013 21840129
46. Adult attachment predicts maternal brain and oxytocin response to infant cues. Strathearn L, Fonagy P, Amico J, Montague PR, Neuropsychopharmacology 2009 34 2655 2666 10.1038/npp.2009.103 19710635
47. Variant in oxytocin receptor gene is associated with amygdala volume. Furman DJ, Chen MC, Gotlib IH, Psychoneuroendocrinology 2011 36 891 897 10.1016/j.psyneuen.2010.12.004 21208749
48. Association between the oxytocin receptor gene and amygdalar volume in healthy adults. Inoue H, Yamasue H, Tochigi M, Abe O, Liu X, Kawamura Y, Takei K, Suga M, Yamada H, Rogers MA, Biol Psychiatry 2010 68 1066 1072 10.1016/j.biopsych.2010.07.019 20832055
49. Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects. Wang J, Qin W, Liu B, Wang D, Zhang Y, Jiang T, Yu C, Neuroimage 2013 81 199 204 23684879
50. Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat. Champagne FA, Chretien P, Stevenson CW, Zhang TY, Gratton A, Meaney MJ, J Neurosci 2004 24 4113 4123 10.1523/JNEUROSCI.5322-03.2004 15115806 (Pubitemid 38620786)
51. FMRI visualization of brain activity during a monetary incentive delay task. Knutson B, Westdorp A, Kaiser E, Hommer D, Neuroimage 2000 12 20 27 10.1006/nimg.2000.0593 10875899 (Pubitemid 30602060)
52. fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder. Smoski MJ, Felder J, Bizzell J, Green SR, Ernst M, Lynch TR, Dichter GS, J Affect Disord 2009 118 69 78 10.1016/j.jad.2009.01.034 19261334
53. Dysfunction of ventral striatal reward prediction in schizophrenia. Juckel G, Schlagenhauf F, Koslowski M, Wüstenberg T, Villringer A, Knutson B, Wrase J, Heinz A, Neuroimage 2006 29 409 416 10.1016/j.neuroimage.2005.07.051 16139525 (Pubitemid 43063297)
54. Abnormal reward system activation in mania. Abler B, Greenhouse I, Ongur D, Walter H, Heckers S, Neuropsychopharmacology 2008 33 2217 2277 10.1038/sj.npp.1301620 17987058 (Pubitemid 351992090)
55. Adolescents, adults and rewards: comparing motivational neurocircuitry recruitment using fMRI. Bjork JM, Smith AR, Chen G, Hommer D, Lauwereyns J, PloS One 2010 51 827 837
56. Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Breiter HC, Aharon I, Kahneman D, Dale A, Shizgal P, Neuron 2001 30 619 639 10.1016/S0896-6273(01)00303-8 11395019 (Pubitemid 32530601)
57. Anticipation of increasing monetary reward selectively recruits nucleus accumbens. Knutson B, Adams CM, Fong GW, Hommer D, J Neurosci 2001 21 1 5
58. Dysfunctional reward circuitry in obsessive-compulsive disorder. Figee M, Vink M, de Geus F, Vulink N, Veltman DJ, Westenberg H, Denys D, Biol Psychiatry 2011 69 867 874 10.1016/j.biopsych.2010.12.003 21272861
59. Incentive-elicited brain activation in adolescents: similarities and differences from young adults. Bjork JM, Knutson B, Fong GW, Caggiano DM, Bennett SM, Hommer D, J Neurosci 2004 24 1793 1802 10.1523/JNEUROSCI.4862-03. 2004 14985419 (Pubitemid 38292790)
60. Functional magnetic resonance imaging of reward prediction. Knutson B, Cooper JC, Curr Opin Neurol 2005 18 411 417 10.1097/01.wco.0000173463.24758.f6 16003117 (Pubitemid 41104804)
61. The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. Israel S, Lerer E, Shalev I, Uzefovsky F, Riebold M, Laiba E, Bachner-Melman R, Maril A, Bornstein G, Knafo A, PLoS One 2009 4 5535 10.1371/journal.pone.0005535 19461999
62. Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. Lerer E, Levi S, Salomon S, Darvasi A, Yirmiya N, Ebstein RP, Mol Psychiatry 2007 13 980 988 17893705
63. The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. Wu N, Li Z, Su Y, J Affect Disord 2012 138 468 472 10.1016/j.jad.2012.01.009 22357335
64. Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population. Liu X, Kawamura Y, Shimada T, Otowa T, Koishi S, Sugiyama T, Nishida H, Hashimoto O, Nakagami R, Tochigi M, J Hum Genet 2010 55 137 141 10.1038/jhg.2009.140 20094064
65. Motivation concepts in behavioral neuroscience. Berridge KC, Physiol Behav 2004 81 179 209 10.1016/j.physbeh.2004.02.004 15159167 (Pubitemid 38670087)
66. First MB, Structured Clinical Interview for DSM-IV Axis I Disorders: SCID-I: Clinician Version: Administration Booklet Washington, DC: American Psychiatric Press 1997
67. Derogatis LR, SCL-90-R: Symptom Checklist-90-R: Administration, Scoring, and Procedures Manual Minneapolis, MN: National Computer Systems 3 1994
68. Patiënten met chronische benigne pijn: nader psychometrisch onderzoek met de SCL-90. [Patients with chronic benign pain: further psychometric research with the SCL-90]. Groenman N, Rober I, Reitsma B, Tuymelaar Koldenhof C, Lousberg R, NVB Pijnbulletin 1993 13 9 12
69. Predicting premorbid IQ: a revision of the national adult reading test. Blair JR, Spreen O, Clin Neuropsychol 1989 3 129 136 10.1080/13854048908403285
70. The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Baron-Cohen S, Wheelwright S, Skinner R, Martin J, Clubley E, J Autism Dev Disord 2001 31 5 17 10.1023/A:1005653411471 11439754
71. International Haplotype Map Project. http://www.hapmap.org
72. Parallel imaging reconstruction for arbitrary trajectories using k space sparse matrices (kSPA). Liu C, Bammer R, Moseley ME, Magn Reson Med 2007 58 1171 1181 10.1002/mrm.21334 17969012 (Pubitemid 350234204)
73. Bayesian analysis of neuroimaging data in FSL. Woolrich MW, Jbabdi S, Patenaude B, Chappell M, Makni S, Behrens T, Beckmann C, Jenkinson M, Smith SM, Neuroimage 2009 45 173 186 10.1016/j.neuroimage.2008.10.055
74. Advances in functional and structural MR image analysis and implementation as FSL. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TEJ, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Neuroimage 2004 23 208 219
75. Fast robust automated brain extraction. Smith SM, Hum Brain Mapp 2002 17 143 155 10.1002/hbm.10062 12391568 (Pubitemid 35253488)
76. Improved optimization for the robust and accurate linear registration and motion correction of brain images. Jenkinson M, Bannister P, Brady M, Smith SM, Neuroimage 2002 17 825 841 10.1006/nimg.2002.1132 12377157 (Pubitemid 35317016)
77. A global optimisation method for robust affine registration of brain images. Jenkinson M, Smith SM, Med Image Anal 2001 5 143 156 10.1016/S1361-8415(01)00036-6 11516708 (Pubitemid 35282800)
78. Multilevel linear modelling for FMRI group analysis using Bayesian inference. Woolrich MW, Behrens TE, Beckmann CF, Jenkinson M, Smith SM, Neuroimage 2004 21 1732 1747 10.1016/j.neuroimage.2003.12.023 15050594 (Pubitemid 38446594)
79. The valuation system: a coordinate-based meta-analysis of BOLD fMRI experiments examining neural correlates of subjective value. Bartra O, McGuire JT, Kable JW, Neuroimage 2013 76 412 427 23507394
80. Parsing reward. Berridge KC, Robinson TE, Trends Neurosci 2003 26 507 513 10.1016/S0166-2236(03)00233-9 12948663 (Pubitemid 37025790)
81. The endophenotype concept in psychiatry: etymology and strategic intentions. Gottesman II, Gould TD, Am J Psychiatr 2003 160 636 636 10.1176/appi.ajp.160.4.636 12668349 (Pubitemid 41079594)
82. From the genome to the phenome and back: linking genes with human brain function and structure using genetically informed neuroimaging. Siebner HR, Callicott JH, Sommer T, Mattay VS, Neuroscience 2009 164 1 6 10.1016/j.neuroscience.2009.09.009 19751805
83. The discipline of neurobehavioral development: the emerging interface of processes that build circuits and skills. Hammock EA, Levitt P, Hum Dev 2006 49 294 309 10.1159/000095581 (Pubitemid 44763195)
84. Dopamine, oxytocin, and vasopressin receptor binding in the medial prefrontal cortex of monogamous and promiscuous voles. Smeltzer MD, Curtis JT, Aragona BJ, Wang Z, Neurosci Lett 2006 394 146 151 10.1016/j.neulet.2005.10.019 16289323 (Pubitemid 43061477)
85. Dopamine and oxytocin interactions underlying behaviors: potential contributions to behavioral disorders. Baskerville TA, Douglas AJ, CNS Neurosci Ther 2010 16 92 e123 10.1111/j.1755-5949.2010.00154.x 20557568
86. Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans. Gamer M, Zurowski B, Büchel C, Proc Natl Acad Sci 2010 107 9400 9405 10.1073/pnas.1000985107 20421469
87. Oxytocin modulates amygdala, insula, and inferior frontal gyrus responses to infant crying: a randomized controlled trial. Riem MME, Bakermans-Kranenburg MJ, Pieper S, Tops M, Boksem MAS, Vermeiren RRJM, van IJzendoorn MH, Rombouts SARB, Biol Psychiatry 2011 70 291 297 10.1016/j.biopsych.2011.02.006 21470595
88. Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Baumgartner T, Heinrichs M, Vonlanthen A, Fischbacher U, Fehr E, Neuron 2008 58 639 650 10.1016/j.neuron.2008.04.009 18498743 (Pubitemid 351672358)
89. Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity. Petrovic P, Kalisch R, Singer T, Dolan RJ, J Neurosci 2008 28 6607 6615 10.1523/JNEUROSCI.4572-07.2008 18579733
90. Oxytocin modulates neural circuitry for social cognition and fear in humans. Kirsch P, Esslinger C, Chen Q, Mier D, Lis S, Siddhanti S, Gruppe H, Mattay VS, Gallhofer B, Meyer-Lindenberg A, J Neurosci 2005 25 11489 11493 10.1523/JNEUROSCI.3984-05.2005 16339042 (Pubitemid 43083720)
91. Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Domes G, Heinrichs M, Glascher J, Buchel C, Braus DF, Herpertz SC, Biol Psychiatry 2007 62 1187 1190 10.1016/j.biopsych.2007.03.025 17617382 (Pubitemid 350029722)
92. Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces. Chakrabarti B, Baron-Cohen S, Molecular Autism 2011 2 10 10.1186/2040-2392-2-10 21714860
93. Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting. Betancur C, Brain Res 2011 1380 42 77 21129364
94. Genetic advances in autism: heterogeneity and convergence on shared pathways. Bill BR, Geschwind DH, Curr Opin Genet Dev 2009 19 271 278 10.1016/j.gde.2009.04.004 19477629
95. Using genetic data in cognitive neuroscience: from growing pains to genuine insights. Green AE, Munafò MR, DeYoung CG, Fossella JA, Fan J, Gray JR, Nat Rev Neurosci 2008 9 710 720 10.1038/nrn2461 19143051
96. Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings. Dichter GS, Damiano CR, Allen JA, J Neurodev Disord 2012 4 1 43 10.1186/1866-1955-4-1 22958445
97. Social effects of oxytocin in humans: context and person matter. Bartz J, Zaki J, Bolger N, Ochsner KN, Trends Cogn Sci 2011 15 301 309 21696997
98. Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans. Heinrichs M, Domes G, Prog Brain Res 2008 170 337 350 18655894 (Pubitemid 352010240)
99. Candidate gene studies of a promising intermediate phenotype: failure to replicate. Hart AB, de Wit H, Palmer AA, Neuropsychopharmacology 2012 38 802 816 23303064
100. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JPA, Hirschhorn JN, Nat Rev Genet 2008 9 356 369 10.1038/nrg2344 18398418 (Pubitemid 351556063)
101. A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans. Bakermans-Kranenburg MJ, van Ijzendoorn MH, Psychiatr Genet 2013
102. Imaging genetics-days of future past. Bigos KL, Weinberger DR, Neuroimage 2010 53 804 809 10.1016/j.neuroimage.2010.01.035 20080192
103. Anticipatory affect: neural correlates and consequences for choice. Knutson B, Greer SM, Phil Trans Roy Soc B: Biol Sci 2008 363 3771 3786 10.1098/rstb.2008.0155
104. Tend and befriend biobehavioral bases of affiliation under stress. Taylor SE, Curr Dir Psychol Sci 2006 15 273 277 10.1111/j.1467-8721.2006.00451.x (Pubitemid 44952722)
105. Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade. Tomizawa K, Iga N, Lu Y-F, Moriwaki A, Matsushita M, Li S-T, Miyamoto O, Itano T, Matsui H, Nat Neurosci 2003 6 384 390 10.1038/nn1023 12598900 (Pubitemid 36373984)