Oxytocin receptor gene polymorphism, perceived social support, and psychological symptoms in maltreated adolescents

Development and Psychopathology

Volumn 26, Issue 2, 2014, Pages 465-477

  Hostinar, Camelia E ^a   Cicchetti, Dante ^a,b   Rogosch, Fred A ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYTOCIN RECEPTOR;

ADOLESCENT; CHILD ABUSE; CHILD SEXUAL ABUSE; CONFLICT; DEPRESSION; FEMALE; GENETICS; GENOTYPE; HUMAN; MALE; MENTAL DISEASE; PSYCHOLOGIC TEST; PSYCHOLOGY; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL SUPPORT; SOCIOECONOMICS;

ADOLESCENT; CHILD ABUSE; CHILD ABUSE, SEXUAL; CONFLICT (PSYCHOLOGY); DEPRESSION; FEMALE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHOLOGICAL TESTS; PSYCHOPATHOLOGY; RECEPTORS, OXYTOCIN; SEX FACTORS; SOCIAL SUPPORT; SOCIOECONOMIC FACTORS;

EID: 84898443195     PISSN: 09545794     EISSN: 14692198     Source Type: Journal    
DOI: 10.1017/S0954579414000066     Document Type: Article

References (92)

1. Achenbach, T. M. (1991). Integrative guide for the 1991 CBCL/4-18, YSR, and TRF profiles. Burlington, VT: Universityof Vermont, Department of Psychiatry.
2. Achenbach, T. M., & Rescorla, L. A. (2001). Manual for the ASEBA School-Age Forms & Profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, & Families.
3. Apicella, C. L., Cesarini, D., Johannesson, M., Dawes, C. T., Lichtenstein, P., Wallace, B., et al. (2010). No association between oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences. PLOS ONE, 5, e11153.
4. Avishai-Eliner, S., Gilles, E. E., Eghbal-Ahmadi, M., Bar-El, Y., & Baram, T. Z. (2001). Altered regulation of gene and protein expression of hypothal-amic-pituitary-adrenal axis components in an immature rat model of chronic stress. Journal of Neuroendocrinology, 13, 799-807.
5. Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2008). Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Social Cognitive and Affective Neuroscience, 3, 128-134.
6. Barnett, D., Manly, J. T., & Cicchetti, D. (1993). Defining child maltreatment: The interface between policy and research. In D. Cicchetti & S. L. Toth (Eds.), Child abuse, child development, and social policy (pp. 7-73). Norwood, NJ: Ablex.
7. Barraza, J. A., & Zak, P. J. (2009). Empathy toward strangers triggers oxyto-cin release and subsequent generosity. Annals of the New York Academy of Sciences, 1167, 182-189.
8. Bolger, K. E., & Patterson, C. J. (2001). Pathways from child maltreatment to internalizing problems: Perceptions of control as mediators and moderators. Development and Psychopathology, 13, 913-940.
9. Bolger, K. E., Patterson, C. J., & Kupersmidt, J. B. (1998). Peer relationships and self-esteem among children who have been maltreated. Child Development, 69, 1171-1197.
10. Bradley, B., Westen, D., Mercer, K. B., Binder, E. B., Jovanovic, T., Crain, D., et al. (2011). Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: Moderation by oxytocin receptor gene. Development and Psychopa-thology, 23, 439-452.
11. Buchheim, A., Heinrichs, M., George, C., Pokorny, D., Koops, E., Henning-sen, P., et al. (2010). Oxytocin enhances the experience of attachment security. Psychoneuroendocrinology, 34, 1417-1422.
12. Carter, C. S. (2007). Sex differences in oxytocin and vasopressin: Implications forautism spectrum disorders? BehaviorandBrain Research, 176, 170-186.
13. Caspi, A., & Moffitt, T. E. (2006). Gene-environment interactions in psychiatry: Joining forces with neuroscience. Nature Reviews Neuroscience, 7, 583-590.
14. Champagne, F., Diorio, J., Sharma, S., & Meaney, M. J. (2001). Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors. Proceedings of the National Academy of Sciences, 98, 12736-12741.
15. Chen, F. S., Kumsta, R., von Dawans, B., Monakhov, M., Ebstein, R. P., & Heinrichs, M. (2011). Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. Proceedings of the National Academy of Sciences, 108, 19937-19942.
16. Chibbar, R., Toma, J. G., Mitchell, B. F., & Miller, F. D. (1990). Regulation of neural oxytocin gene expression by gonadal steroids in pubertal rats. Molecular Endocrinology, 4, 2030-2038.
17. Cicchetti, D. (2010). Resilience under conditions of extreme stress: A multilevel perspective. World Psychiatry, 9, 1-10.
18. Cicchetti, D. (2013). Resilient functioning in maltreated children: Past, present, and future perspectives. Journal of Child Psychology and Psychiatry, 54, 402-422.
19. Cicchetti, D., & Barnett, D. (1991). Attachment organization in maltreated preschoolers. Development and Psychopathology, 3, 397-411.
20. Cicchetti, D., & Blender, J. A. (2006). A multiple-levels-of-analysis perspective on resilience: Implications for the developing brain, neural plasticity, and preventive interventions. Annals of the New York Academy of Sciences, 1094, 248-258.
21. Cicchetti, D., & Lynch, M. (1995). Failures in the expectable environment and their impact on individual development: The case of child maltreatment. In D. Cicchetti & D. J. Cohen (Eds.), Developmental psychopathology: Risk, disorder, and adaptation (Vol. 2, pp. 32-71). New York: Wiley.
22. Cicchetti, D., & Rogosch, F. A. (1997). The role of self-organization in the promotion of resilience in maltreated children. Development and Psycho-pathology, 9, 799-817.
23. Cicchetti, D., & Rogosch, F. A. (2012). Gene x Environment interaction and resilience: Effects of child maltreatment and serotonin, corticotropin releasing hormone, dopamine, and oxytocin genes. Development and Psychopathology, 24, 411-427.
24. Cicchetti, D., Rogosch, F. A., & Toth, S. L. (2006). Fostering secure attachment in infants in maltreating families through preventive interventions. Development and Psychopathology, 18, 623-649.
25. Cicchetti, D., Toth, S. L., & Manly, J. T. (2003). Maternal Maltreatment Interview. Unpublished manuscript.
26. Cicchetti, D., & Valentino, K. (2006). An ecological transactional perspective on child maltreatment: Failure of the average expectable environment and its influence upon child development. In D. Cicchetti & D. J. Cohen (Eds.), Developmental psychopathology (Vol. 3, 2nd ed., pp. 129-201). Hoboken, NJ: Wiley.
27. Cohen, S. (2004). Social relationships and health. American Psychologist, 59, 676-684.
28. Costa, B., Pini, S., Gabelloni, P., Abelli, M., Lari, L., Cardini, A., et al. (2009). Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology, 34, 1506-1514.
29. Crone, E. A., & Dahl, R. E. (2012). Understanding adolescence as aperiod of social-affective engagement and goal flexibility. Nature Reviews Neu-roscience, 13, 636-650.
30. Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2009). Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biological Psychiatry, 65, 728-731.
31. Domes, G., Heinrichs, M., Michel, A., Berger, C, & Herpertz, S. C. (2007). Oxytocin improves "mind-reading" in humans. Biological Psychiatry, 61, 731-733.
32. Donaldson, Z. R., & Young, L. J. (2008). Oxytocin, vasopressin, and the neurogenetics of sociality. Science, 322, 900-904.
33. Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012). The contributions of oxytocin and vasopressin pathway genes to human behavior. Hormones and Behavior, 61, 359-379.
34. Feldman, R., Gordon, I., Schneiderman, I., Weisman, O., & Zagoory-Sharon, O. (2010). Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent-infant contact. Psychoneuroendocrinology, 35, 1133-1141.
35. Furman, W., & Buhrmester, D. (1992). Age and sex differences in perceptions of networks of personal relationships. Child Development, 63, 103-115.
36. Galbally, M., Lewis, A. J., IJzendoorn, M., & Permezel, M. (2011). The role of oxytocin in mother-infant relations: A systematic review of human studies. Harvard Review of Psychiatry, 19, 1-14.
37. Gillath, O., Shaver, P. R., Baek, J.-M., & Chun, D. S. (2008). Genetic correlates of adult attachment style. Personality & Social Psychology Bulletin, 34, 1396-1405.
38. Gimpl, G., & Fahrenholz, F. (2001). The oxytocin receptor system: Structure, function, and regulation. Physiological Reviews, 81, 629-683.
39. Gordon, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2010). Oxy-tocin and the development of parenting in humans. Biological Psychiatry, 68, 377-382.
40. Grant, K. E., Compas, B. E., Stuhlmacher, A. F., Thurm, A. E., McMahon, S. D., & Halpert, J. A. (2003). Stressors and child and adolescent psychopa-thology: Moving from markers to mechanisms of risk. Psychological Bulletin, 129, 447-466.
41. Heim, C., Young, L. J., Newport, D. J., Mletzko, T., Miller, A. H., & Nemer-off, C. B. (2009). Lower CSF oxytocin concentrations in women with a history of childhood abuse. Molecular Psychiatry, 14, 954-958.
42. Heinrichs, M., & Domes, G. (2008). Neuropeptides and social behaviour: Effects of oxytocin and vasopressin in humans. Progress in Brain Research, 170, 337-350.
43. Hennessy, M. B., Kaiser, S., & Sachser, N. (2009). Social buffering of the stress response: Diversity, mechanisms, and functions. Frontiers in Neu-roendocrinology, 30, 470-482.
44. Hostinar, C. E., Sullivan, R. M., & Gunnar, M. R. (2014). Psychobiological mechanisms underlying the social buffering of the HPA axis: A review of animal models and human studies across development. Psychological Bulletin, 140, 256-282. doi:10.1037/a0032671
45. Inoue, T., Kimura, T., Azuma, C., Inazawa, J., Takemura, M., Kikuchi, T., et al. (1994). Structural organization of the human oxytocin receptor gene. Journal of Biological Chemistry, 269, 32451-32456.
46. Insel, T. R., & Shapiro, L. E. (1992). Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles. Proceedings of the National Academy of Sciences, 89, 5981-5985.
47. Jacob, S., Brune, C. W., Carter, C. S., Leventhal, B. L., Lord, C., & Cook, E. H. (2007). Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. Neuroscience Letters, 417, 6-9.
48. Jostins, L., Pickrell, J. K., MacArthur, D. G., & Barretta, J. C. (2012). Misuse of hierarchical linear models overstates the significance of a reported association between OXTR and prosociality. Proceedings of the National Academy of Sciences, 109, E1048.
49. Kaplow, J. B., & Widom, C. S. (2007). Age of onset of child maltreatment predicts long-term mental health outcomes. Journal of Abnormal Psychology, 116, 176-187.
50. Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Archives of General Psychiatry, 68, 444-454.
51. Kim, H. S., Sherman, D. K., Sasaki, J. Y., Xu, J., Chu, T. Q., Ryu, et al. (2010). Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proceedings of the National Academy of Sciences, 107, 15717-15721.
52. Kogan, A., Saslow, L. R., Impett, E. A, Oveis, C., Keltner, D., & Rodrigues Saturn, S. (2011). Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition. Proceedings of the National Academy of Sciences, 108, 19189-19192.
53. Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435, 673-676.
54. Krueger, F., Parasuraman, R., Iyengar, V., Thornburg, M., Weel, J., Lin, M., et al. (2012). Oxytocin receptor genetic variation promotes human trust behavior. Frontiers in Human Neuroscience, 6, 4.
55. Lucht, M. J., Barnow, S., Sonnenfeld, C., Rosenberger, A., Grabe, H. J., Schroeder, W., et al. (2009). Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33, 860-866.
56. Maestripieri, D. (2005). Early experience affects the intergenerational transmission of infant abuse in rhesus monkeys. Proceedings of the National Academy of Sciences, 102, 9726-9729.
57. Malik, A. I., Zai, C. C., Abu, Z., Nowrouzi, B., & Beitchman, J. H. (2012). The role of oxytocin and oxytocin receptor gene variants in childhood-onset aggression. Genes, Brain, and Behavior, 11, 545-551.
58. Manly, J. T., Cicchetti, D., & Barnett, D. (1994). The impact of subtype, frequency, chronicity, and severity of child maltreatment on social competence and behavior problems. Development and Psychopathology, 6, 121-143.
59. Manly, J. T., Kim, J. E., Rogosch, F. A., & Cicchetti, D. (2001). Dimensions of child maltreatment and children's adjustment: Contributions of developmental timing and subtype. Development and Psychopathology, 13, 759-782.
60. Manly, T. J. (2005). Advances in research definitions in child development. Child Abuse and Neglect, 29, 425-439.
61. Masten, A. S. (2001). Ordinary magic: Resilience processes in development. American Psychologist, 56, 227-238.
62. Meinlschmidt, G., & Heim, C. (2007). Sensitivity to intranasal oxytocin in adult men with early parental separation. Biological Psychiatry, 61, 1109-1111.
63. Merikangas, K. R., He, J. P., Burstein, M., Swanson, S. A., Avenevoli, S., Cui, L., et al. (2010). Lifetime prevalence of mental disorders in U.S. adolescents: Results from the National Comorbidity Survey Replication-Adolescent supplement (NCS-A). Journal of the American Academy of Child & Adolescent Psychiatry, 49, 980-989.
64. Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011). Oxy-tocin and vasopressin in the human brain: Social neuropeptides for trans-lational medicine. Nature Reviews Neuroscience, 12, 524-538.
65. Monroe, S. M., & Reid, M. W. (2008). Gene-environment interactions in depression: Genetic polymorphisms and life stress polyprocedures. Psychological Science, 19, 947-956.
66. Montag, C., Brockmann, E. M., Lehmann, A., Müller, D. J., Rujescu, D., & Gallinat, J. (2012). Association between oxytocin receptor gene polymorphisms and self-rated "empathic concern" in schizophrenia. PLOS One, 7, e51882.
67. Morhenn, V., Park, J., Piper, E., & Zak, P. (2008). Monetary sacrifice among strangers is mediated by endogenous oxytocin release after physical contact. Evolution and Human Behavior, 29, 375-383.
68. Naber, F., van IJzendoorn, M. H., Deschamps, P., van Engeland, H., & Ba-kermans-Kranenburg, M. J. (2010). Intranasal oxytocin increases fathers' observed responsiveness during play with their children: A double-blind within-subject experiment. Psychoneuroendocrinology, 35, 1583-1586.
69. Neumann, I. D. (2008). Brain oxytocin: A key regulator of emotional and social behaviours in both females and males. Journal of Neuroendocrinol-ogy, 20, 858-865.
70. Nolen-Hoeksema, S. (2012). Emotion regulation and psychopathology: The role of gender. Annual Reviews in Clinical Psychology, 8, 161-187.
71. Poulin, M., Holman, E. A., & Buffone, A. (2012). The neurogenetics of nice: Receptor genes for oxytocin and vasopressin interact with threat to predict prosocial behavior. Psychological Science, 23, 446-452.
72. Raineki, C., Moriceau, S., & Sullivan, R. M. (2010). Developing a neurobe-havioral animal model of infant attachment to an abusive caregiver. Biological Psychiatry, 67, 1137-1145.
73. Riem, M. M. E., Pieper, S., Out, D., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Oxytocin receptor gene and depressive symptoms associated with physiological reactivity to infant crying. Social Cognitive and Affective Neuroscience, 6, 294-300.
74. Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proceedings of the National Academy of Sciences, 106, 21437-21441.
75. Rogosch, F. A., Cicchetti, D., & Aber, J. L. (1995). The role of child maltreatment in early deviations in cognitive and affective processing abilities and later peer relationship problems. Development and Psychopathology, 7, 591.
76. Rogosch, F. A., Dackis, M. N., & Cicchetti, D. (2011). Child maltreatment and allostatic load: Consequences for physical and mental health in children from low-income families. Development and Psychopathology, 23, 1107-1124.
77. Rogosch, F. A., Oshri, A., & Cicchetti, D. (2010). From child maltreatment to adolescent cannabis abuse and dependence: A developmental cascade model. Development and Psychopathology, 22, 883-897.
78. Roth, T., & Sullivan, R. M. (2005). Memory of early maltreatment: Neonatal behavioral and neural correlates of maternal maltreatment within the context of classical conditioning. Biological Psychiatry, 57, 823-831.
79. Rutter, M. (2010). Gene-environment interplay. Depression and Anxiety, 27, 1-4.
80. Sakai, J. T., Crowley, T. J., Stallings, M. C., McQueen, M., Hewitt, J. K., Hopfer, C., et al. (2012). Test of association between 10 single nucleotide polymorphisms in the oxytocin receptor gene and conduct disorder. Psychiatric Genetics, 22, 99-102.
81. Saphire-Bernstein, S., Way, B. M., Kim, H. S., Sherman, D. K., & Taylor, S. E. (2011). Oxytocin receptor gene (OXTR) is related to psychological resources. Proceedings of the National Academy of Sciences, 108, 15118-15122.
82. Scott, K. L., Wolfe, D. A., & Wekerle, C. (2003). Maltreatment and trauma: Tracking the connections in adolescence. Child and Adolescent Psychiatric Clinics of North America, 12, 211-230.
83. Sedlak, A. J., Mettenburg, J., Basena, M., Petta, I., McPherson, K., Green, A., et al. (2010). The Fourth National Incidence Study of Child Abuse and Neglect (NIS-4): Report to Congress. Washington, DC: US Department of Health and Human Services, Administration for Children and Families.
84. Seltzer, L. J., Ziegler, T. E., & Pollak, S. D. (2011). Social vocalizations can release oxytocin in humans. Proceedings of the Royal Society B: Biological Sciences, 277, 2661-2666.
85. Sturge-Apple, M. L., Cicchetti, D., Davies, P. T., & Suor, J. H. (2012). Differential susceptibility in spillover between interparental conflict and maternal parenting practices: Evidence for OXTR and 5-HTT genes. Journal of Family Psychology, 26, 431-442.
86. Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., et al. (2005). Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proceedings of the National Academy of Sciences, 102, 16096-16101.
87. Tharner, A., Luijk, M. P., Raat, H., Ijzendoorn, M. H., Bakermans-Kranen-burg, M. J., Moll, H., et al. (2012). Breastfeeding and its relation to maternal sensitivity and infant attachment. Journal of Developmental and Behavioral Pediatrics, 33, 396-404.
88. Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., et al. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-lim-bic structure and function. Proceedings of the National Academy of Sciences, 107, 13936-13941.
89. van IJzendoorn, M. H., Belsky, J., & Bakermans-Kranenburg, M. J. (2012). Serotonin transporter genotype 5HTTLPR as a marker of differential susceptibility? A meta-analysis of child and adolescent gene-by-environment studies. Translational Psychiatry, 2, e147.
90. Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Shuang, M., et al. (2005). Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biological Psychiatry, 58, 74-77.
91. Zak, P. J., Kurzban, R., & Matzner, W. T. (2005). Oxytocin is associated with human trustworthiness. Hormones and Behavior, 48, 522-527.
92. Zak, P. J., Stanton, A. A., & Ahmadi, S. (2007). Oxytocin increases generosity in humans. PLOS ONE, 2, e1128.