The PH domain of phosphoinositide-dependent kinase-1 exhibits a novel, phospho-regulated monomer-dimer equilibrium with important implications for kinase domain activation: Single-molecule and ensemble studies

Biochemistry

Volumn 52, Issue 28, 2013, Pages 4820-4829

  Ziemba, Brian P ^a   Pilling, Carissa ^a   Calleja, Véronique ^b   Larijani, Banafshé ^b   Falke, Joseph J ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; ELECTROSTATIC CONTROL; MEMBRANE AFFINITY; MOLECULAR PICTURES; MONOMER-DIMER EQUILIBRIUM; OLIGOMERIC STATE; SIGNALING LIPIDS; SINGLE-MOLECULE ANALYSIS;

ACTIVATION ANALYSIS; BINDING SITES; CELL MEMBRANES; CYTOLOGY; DIMERIZATION; ENZYMES; LIPID BILAYERS; MOLECULES; MONOMERS; PROTEINS;

DIMERS;

DIMER; MONOMER; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL MEMBRANE; CYTOPLASM; DIFFUSION; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; LIPID BILAYER; LIPID COMPOSITION; MEMBRANE BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION;

3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES; DIMERIZATION; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; LIPID BILAYERS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY;

EID: 84880534471     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400488f     Document Type: Article

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