PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells

American Journal of Physiology - Cell Physiology

Volumn 305, Issue 3, 2013, Pages

  Zachos, Nicholas C ^a   Lee, Luke J ^a   Kovbasnjuk, Olga ^a   Li, Xuhang ^a   Donowitz, Mark ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

C Src; Complexes; NHE3; PLC

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; CARBACHOL; PHOSPHOLIPASE C GAMMA; PROTEIN SH2; PROTEIN TYROSINE KINASE; SODIUM PROTON EXCHANGE PROTEIN 3;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL STRAIN CACO 2; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; ENDOCYTOSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

C-SRC; COMPLEXES; NHE3; PLC-Γ;

ANALGESICS, NON-NARCOTIC; CACO-2 CELLS; CALCIUM; CARBACHOL; CELL LINE, TUMOR; ENZYME ACTIVATION; GENES, SRC; HUMANS; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS PP60(C-SRC); PYRIMIDINES; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER;

EID: 84881021023     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00277.2012     Document Type: Article

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