Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice

Gastroenterology

Volumn 145, Issue 4, 2013, Pages 808-819

  Melendez, Jaime ^a,b   Liu, Ming ^a   Sampson, Leesa ^a   Akunuru, Shailaja ^a   Han, Xiaonan ^a   Vallance, Jefferson ^a   Witte, David ^a   Shroyer, Noah ^a   Zheng, Yi ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Proliferation Polarity Conditional Deletion MVID Model

Indexed keywords

ALKALINE PHOSPHATASE; PROTEIN CDC42; CDC42 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL MIGRATION; CELL POLARITY; CELL PROLIFERATION; COLON; CONTROLLED STUDY; ENTEROENDOCRINE CELL; GENE TARGETING; HUMAN; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; INTESTINE BIOPSY; INTESTINE CRYPT; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA PERMEABILITY; MICROVILLUS; MOUSE; NONHUMAN; PANETH CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SMALL INTESTINE; STEM CELL; STOMACH; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; CELL MOTION; CYTOLOGY; INTESTINE MUCOSA; PHYSIOLOGY;

ANIMALS; CDC42 GTP-BINDING PROTEIN; CELL DIFFERENTIATION; CELL MOVEMENT; CELL POLARITY; CELL PROLIFERATION; INTESTINAL MUCOSA; INTESTINE, SMALL; MICE;

EID: 84884372252     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.06.021     Document Type: Article

References (44)

1. C. Crosnier, D. Stamataki, and J. Lewis Organizing cell renewal in the intestine: stem cells, signals and combinatorial control Nat Rev Genet 7 2006 349 359
2. S. Umar Intestinal stem cells Curr Gastroenterol Rep 12 2010 340 348
3. D.I. Johnson, and J.R. Pringle Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity J Cell Biol 111 1990 143 152
4. D.G. Drubin Development of cell polarity in budding yeast Cell 65 1991 1093 1096
5. D.I. Johnson Cdc42: an essential Rho-type GTPase controlling eukaryotic cell polarity Microbiol Mol Biol Rev 63 1999 54 105
6. M. Gotta, M.C. Abraham, and J. Ahringer CDC-42 controls early cell polarity and spindle orientation in C. elegans Curr Biol 11 2001 482 488
7. A.J. Kay, and C.P. Hunter CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans Curr Biol 11 2001 474 481
8. D. Lin, A.S. Edwards, and J.P. Fawcett A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity Nat Cell Biol 2 2000 540 547
9. Y. Noda, R. Takeya, and S. Ohno Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C Genes Cells 6 2001 107 119
10. A. Suzuki, and S. Ohno The PAR-aPKC system: lessons in polarity J Cell Sci 119 Pt 6 2006 979 987
11. X.R. Bustelo, V. Sauzeau, and I.M. Berenjeno GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo Bioessays 29 2007 356 370
12. R.A. Cerione Cdc42: new roads to travel Trends Cell Biol 14 2004 127 132
13. J.W. Erickson, and R.A. Cerione Multiple roles for Cdc42 in cell regulation Curr Opin Cell Biol 13 2001 153 157
14. L. Wang, and Y. Zheng Cell type-specific functions of Rho GTPases revealed by gene targeting in mice Trends Cell Biol 17 2007 58 64
15. S.J. Heasman, and A.J. Ridley Mammalian Rho GTPases: new insights into their functions from in vivo studies Nat Rev Mol Cell Biol 9 2008 690 701
16. L. Yang, L. Wang, and Y. Zheng Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts Mol Biol Cell 17 2006 4675 4685
17. A.B. Jaffe, N. Kaji, J. Durgan, and A. Hall Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis J Cell Biol 183 2008 625 633
18. F. Martin-Belmonte, A. Gassama, and A. Datta PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42 Cell 128 2007 383 397
19. R. Rojas, W.G. Ruiz, and S.M. Leung Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized Madin-Darby canine kidney cells Mol Biol Cell 12 2001 2257 2274
20. G. Kesavan, F.W. Sand, and T.U. Greiner Cdc42-mediated tubulogenesis controls cell specification Cell 139 2009 791 801
21. E.E. Govek, S.E. Newey, and L. Van Aelst The role of the Rho GTPases in neuronal development Genes Dev 19 2005 1 49
22. N. Osmani, N. Vitale, J.P. Borg, and S. Etienne-Manneville Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration Curr Biol 16 2006 2395 2405
23. S. Cappello, A. Attardo, and X. Wu The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface Nat Neurosci 9 2006 1099 1107
24. L. Chen, G. Liao, and L. Yang Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly Proc Natl Acad Sci U S A 103 2006 16520 16525
25. J. Melendez, M. Grogg, and Y. Zheng Signaling role of Cdc42 in regulating mammalian physiology J Biol Chem 286 2011 2375 2381
26. J. Guo, S. Longshore, R. Nair, and B.W. Warner Retinoblastoma protein (pRb), but not p107 or p130, is required for maintenance of enterocyte quiescence and differentiation in small intestine J Biol Chem 284 2009 134 140
27. B.B. Madison, L. Dunbar, and X.T. Qiao Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine J Biol Chem 277 2002 33275 33283
28. F. el Marjou, K.P. Janssen, and B.H. Chang Tissue-specific and inducible Cre-mediated recombination in the gut epithelium Genesis 39 2004 186 193
29. B.D. Lake Microvillus inclusion disease: specific diagnostic features shown by alkaline phosphatase histochemistry J Clin Pathol 41 1988 880 882
30. A. Hall Rho GTPases and the actin cytoskeleton Science 279 5350 1998 509 514
31. J. van Hengel, P. D'Hooge, and B. Hooghe Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver Gastroenterology 134 2008 781 792
32. V. Vasioukhin, C. Bauer, and L. Degenstein Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin Cell 104 2001 605 617
33. M. Perez-Moreno, W. Song, and H.A. Pasolli Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer Proc Natl Acad Sci U S A 105 2008 15399 15404
34. W.G. Smalley-Freed, A. Efimov, and P.E. Burnett p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice J Clin Invest 120 2010 1824 1835
35. M.R. Schneider, M. Dahlhoff, and D. Horst A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation PLoS One 5 2010 e14325
36. D.M. Bryant, A. Datta, and A.E. Rodríguez-Fraticelli A molecular network for de novo generation of the apical surface and lumen Nat Cell Biol 12 2010 1035 1045
37. J. Durgan, N. Kaji, D. Jin, and A. Hall Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis J Biol Chem 286 2011 12461 12474
38. X. Wu, F. Quondamatteo, and T. Lefever Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin Genes Dev 20 2006 571 585
39. Y.S. Chu, W.A. Thomas, and O. Eder Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42 J Cell Biol 167 2004 1183 1194
40. S. Kuroda, M. Fukata, and M. Nakagawa Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion Science 281 5378 1998 832 835
41. T. Sato, J.H. van Es, and H.J. Snippert Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts Nature 469 7330 2011 415 418
42. T. Müller, M.W. Hess, and N. Schiefermeier MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity Nat Genet 40 2008 1163 1165
43. T. Sato, S. Mushiake, and Y. Kato The Rab8 GTPase regulates apical protein localization in intestinal cells Nature 448 7151 2007 366 369
44. R. Sakamori, S. Das, and S. Yu Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice J Clin Invest 122 2012 1052 1065