Aberrant expression of the polarity complex atypical PKC and non-muscle myosin IIA in active and inactive inflammatory bowel disease

Virchows Archiv

Volumn 459, Issue 3, 2011, Pages 331-338

  Wald, Flavia A ^a   Forteza, Radia ^a   Diwadkar Watkins, Runa ^a   Mashukova, Anastasia ^a   Duncan, Robert ^a   Abreu, Maria T ^a   Salas, Pedro J ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Crohn's disease; Epithelial polarity; Non muscle myosin IIA; PKC ; PKC ; Ulcerative colitis

Indexed keywords

MYOSIN IIA; MYOSIN LIGHT CHAIN KINASE; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL STRAIN CACO 2; CLINICAL ARTICLE; CROHN DISEASE; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ULCERATIVE COLITIS; UPREGULATION;

CELL MEMBRANE; CELL POLARITY; COHORT STUDIES; COLITIS; COLON; DOWN-REGULATION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; ISOENZYMES; MALE; MICROSCOPY, CONFOCAL; NONMUSCLE MYOSIN TYPE IIA; PERMEABILITY; PHOSPHORYLATION; PROTEIN KINASE C; STAINING AND LABELING; TISSUE DISTRIBUTION; UP-REGULATION;

EID: 80052397136     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-011-1102-1     Document Type: Article

References (28)

1. A Suzuki S Ohno 2006 The PAR-aPKC system: lessons in polarity J Cell Sci 119 979 987 16525119 10.1242/jcs.02898 1:CAS:528:DC%2BD28Xjs1yrsbo%3D
2. S Guo KJ Kemphues 1996 Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo Curr Opin Genet Dev 6 408 415 8791533 10.1016/S0959-437X(96)80061-X 1:CAS:528:DyaK28Xlt1Kmtro%3D (Pubitemid 26280792)
3. IG Macara 2004 Parsing the polarity code Nat Rev Mol Cell Biol 5 220 231 14991002 10.1038/nrm1332 1:CAS:528:DC%2BD2cXhs1Clt7Y%3D (Pubitemid 38325803)
4. G Tanentzapf U Tepass 2003 Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization Nat Cell Biol 5 46 52 12510193 10.1038/ncb896 1:CAS:528:DC%2BD3sXivFCn (Pubitemid 36054328)
5. TW Hurd L Gao MH Roh, et al. 2003 Direct interaction of two polarity complexes implicated in epithelial tight junction assembly Nat Cell Biol 5 137 142 12545177 10.1038/ncb923 1:CAS:528:DC%2BD3sXot12quw%3D%3D (Pubitemid 36210848)
6. JM Anderson CM Van Itallie AS Fanning 2004 Setting up a selective barrier at the apical junction complex Curr Opin Cell Biol 16 140 145 15196556 10.1016/j.ceb.2004.01.005 1:CAS:528:DC%2BD2cXjslWktLc%3D (Pubitemid 38757290)
7. AE Mertens TP Rygiel C Olivo, et al. 2005 The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex J Cell Biol 170 1029 1037 16186252 10.1083/jcb.200502129 1:CAS:528:DC%2BD2MXhtVKnsbrK (Pubitemid 41362635)
8. CM Gould AC Newton 2008 The life and death of protein kinase C Curr Drug Targets 9 614 625 18691009 10.2174/138945008785132411 1:CAS:528: DC%2BD1cXpsVymurc%3D
9. NA Bulgakova E Knust 2009 The Crumbs complex: from epithelial-cell polarity to retinal degeneration J Cell Sci 122 2587 2596 19625503 10.1242/jcs.023648 1:CAS:528:DC%2BD1MXhtVGhsL%2FM
10. SM Rothenberg G Mohapatra MN Rivera, et al. 2010 A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers Cancer Res 70 2158 2164 20215515 10.1158/0008-5472.CAN-09-3458 1:CAS:528:DC%2BC3cXjtFygtr0%3D
11. MG Laukoetter P Nava A Nusrat 2008 Role of the intestinal barrier in inflammatory bowel disease World J Gastroenterol 14 401 407 18200662 10.3748/wjg.14.401 1:CAS:528:DC%2BD1cXjvFKkt7c%3D (Pubitemid 351320848)
12. A Mashukova FA Wald PJ Salas 2011 Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism Mol Cell Biol 31 756 765 21135124 10.1128/MCB.00811-10 1:CAS:528:DC%2BC3MXisVyitrw%3D
13. A Mashukova AS Oriolo FA Wald, et al. 2009 Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones J Cell Sci 122 2491 2503 19549684 10.1242/jcs.046979 1:CAS:528:DC%2BD1MXpvFGmu7c%3D
14. MJ Ciancio EB Chang 2008 Do heat shock proteins play any role in gut inflammation? Inflamm Bowel Dis 14 Suppl 2 S102 S103 18816666 10.1002/ibd.20697
15. AM Marchiando WV Graham JR Turner 2010 Epithelial barriers in homeostasis and disease Annu Rev Pathol 5 119 144 20078218 10.1146/annurev.pathol.4.110807. 092135 1:CAS:528:DC%2BC3cXivFekt7o%3D
16. SA Blair SV Kane DR Clayburgh, et al. 2006 Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease Lab Invest 86 191 201 16402035 10.1038/labinvest.3700373 1:CAS:528: DC%2BD28Xlt1elsA%3D%3D (Pubitemid 43117598)
17. G Totsukawa Y Yamakita S Yamashiro, et al. 2000 Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts J Cell Biol 150 797 806 10953004 10.1083/jcb.150.4.797 1:CAS:528:DC%2BD3cXmtVemu7k%3D (Pubitemid 30663416)
18. F Matsumura G Totsukawa Y Yamakita, et al. 2001 Role of myosin light chain phosphorylation in the regulation of cytokinesis Cell Struct Funct 26 6 639 644 11942620 10.1247/csf.26.639 1:CAS:528:DC%2BD38XjtVGmsLw%3D (Pubitemid 34464431)
19. AI Ivanov CA Parkos A Nusrat 2010 Cytoskeletal regulation of epithelial barrier function during inflammation Am J Pathol 177 512 524 20581053 10.2353/ajpath.2010.100168 1:CAS:528:DC%2BC3cXhtFCrtbfO
20. AI Ivanov M Bachar BA Babbin, et al. 2007 A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctions PLoS One 2 e658 17668046 10.1371/journal.pone.0000658 (Pubitemid 351314882)
21. K Hayashi S Yonemura T Matsui, et al. 1999 Immunofluorescence detection of ezrin/radixin/moesin (ERM) proteins with their carboxyl-terminal threonine phosphorylated in cultured cells and tissues J Cell Sci 112 1149 1158 10085250 1:CAS:528:DyaK1MXjtFGhs7c%3D
22. FA Wald AS Oriolo A Mashukova, et al. 2008 Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells J Cell Sci 121 644 654 18270268 10.1242/jcs.016246 1:CAS:528:DC%2BD1cXkslOls7Y%3D (Pubitemid 351524163)
23. A Suzuki T Yamanaka T Hirose, et al. 2001 Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures J Cell Biol 152 1183 1196 11257119 10.1083/jcb.152.6.1183 1:CAS:528: DC%2BD3MXit1egt74%3D (Pubitemid 34280176)
24. S Even-Ram AD Doyle MA Conti, et al. 2007 Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk Nature Cell Biol 9 299 309 17310241 10.1038/ncb1540 1:CAS:528:DC%2BD2sXit12ku7s%3D (Pubitemid 46344609)
25. T Watanabe H Hosoya S Yonemura 2007 Regulation of myosin II dynamics by phosphorylation and dephosphorylation of its light chain in epithelial cells Mol Biol Cell 18 605 616 17151359 10.1091/mbc.E06-07-0590 1:CAS:528: DC%2BD2sXhsFartrw%3D (Pubitemid 46213228)
26. BA Babbin S Koch M Bachar, et al. 2009 Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion Am J Pathol 174 436 448 19147824 10.2353/ajpath.2009.080171 1:CAS:528:DC%2BD1MXivVWnsb0%3D
27. F Wang WV Graham Y Wang, et al. 2005 Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression Am J Pathol 166 409 419 15681825 10.1016/S0002-9440(10)62264-X 1:CAS:528:DC%2BD2MXitVGnurk%3D (Pubitemid 40189038)
28. A Suzuki C Ishiyama K Hashiba, et al. 2002 aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization J Cell Sci 115 3565 3573 12186943 10.1242/jcs.00032 1:CAS:528:DC%2BD38XnvFGns7o%3D