Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice

Journal of Neurochemistry

Volumn 122, Issue 6, 2012, Pages 1211-1218

  Santhanam, Anantha Vijay R ^a   D'Uscio, Livius V ^a   Smith, Leslie A ^a   Katusic, Zvonimir S ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

cerebral microvasculature; endothelial dysfunction; GTP cyclohydrolase I; oxidative stress

Indexed keywords

3 NITROTYROSINE; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; MANGANESE SUPEROXIDE DISMUTASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; SUPEROXIDE; TETRAHYDROBIOPTERIN;

ANIMAL TISSUE; ARTICLE; BRAIN BLOOD VESSEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME LOCALIZATION; FEMALE; HETEROZYGOSITY; HOMOZYGOSITY; HYPERPHENYLALANINEMIA; MALE; MICROVASCULATURE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; CYCLIC GMP; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROVESSELS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PHENYLALANINE HYDROXYLASE; SIGNAL TRANSDUCTION; SUPEROXIDES;

MUS;

EID: 84865779006     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07872.x     Document Type: Article

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