RhoA signaling through platelet P2Y1 receptor controls leukocyte recruitment in allergic mice

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 2, 2015, Pages 528-538.e4

  Amison, Richard T ^a   Momi, Stefania ^b   Morris, Abigail ^a   Manni, Giorgia ^b   Keir, Sandra ^a   Gresele, Paolo ^b   Page, Clive P ^a   Pitchford, Simon C ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

allergic inflammation; P2X1; P2Y12; P2Y1; Platelets; RhoA

Indexed keywords

2 PROPYLTHIO DEXTRO BETA,GAMMA DIFLUOROMETHYLENE ADENOSINE TRIPHOSPHATE; 2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; 2,2 DIMETHYL PROPIONIC ACID 3 [2 CHLORO 6 METHYLAMINOPURIN 9 YL] 2 [2,2 DIMETHYL PROPIONYLOXYMETHYL]PROPYL ESTER; 4 (2 IODO 6 METHYLAMINO 9H PURIN 9 YL) 2 PHOSPHONOOXYBICYCLO[3.1.0]HEXANE 1 METHANOL; 4 [4 (TRIFLUOROMETHYL)PHENYL] N [6 FLUORO 1H INDAZOL 5 YL] 2 METHYL 6 OXO 1,4,5,6 TETRAHYDRO 3 PYRIDINECARBOXAMIDE; 8 8' [CARBONYLBIS(IMINO 4,1 PHENYLENECARBONYLIMINO 4,1 PHENYLENECARBONYLIMINIO)]BIS 1,3,5 NAPHTHALENETRISULFONIC ACID; ADENOSINE DERIVATIVE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ANTIALLERGIC AGENT; ANTIINFLAMMATORY AGENT; CLOPIDOGREL; OVALBUMIN; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; PURINE NUCLEOTIDE; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE; ALLERGEN; CHEMOKINE; PURINERGIC P2Y RECEPTOR AGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY CELL; LEUKOCYTE AGGREGATION; LEUKOCYTE MIGRATION; LEUKOCYTE MIGRATION INHIBITION; LUNG ALVEOLUS CELL; LUNG LAVAGE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OVALBUMIN-INDUCED AIRWAY INFLAMMATION; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE FUNCTION; THROMBOCYTOPENIA; ANIMAL; BIOLOGICAL MODEL; DISEASE MODEL; HYPERSENSITIVITY; IMMUNOLOGY; LEUKOCYTE; LUNG; MACROPHAGE; METABOLISM; THROMBOCYTE;

ADENOSINE DIPHOSPHATE; ALLERGENS; ANIMALS; BLOOD PLATELETS; CHEMOKINES; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; FEMALE; HYPERSENSITIVITY; LEUKOCYTES; LUNG; MACROPHAGES; MICE; MODELS, BIOLOGICAL; OVALBUMIN; P-SELECTIN; PLATELET AGGREGATION; PURINERGIC P2Y RECEPTOR AGONISTS; RECEPTORS, PURINERGIC P2Y1; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84922357090     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.09.032     Document Type: Article

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