A platelet target for venous thrombosis? P2Y1 deletion or antagonism protects mice from vena cava thrombosis

Journal of Thrombosis and Thrombolysis

Volumn 34, Issue 2, 2012, Pages 199-207

  Bird, J Eileen ^a   Wang, Xinkang ^b   Smith, Patricia L ^a   Barbera, Frank ^a   Huang, Christine ^a   Schumacher, William A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b AGENNIX INC   (United States)

Author keywords

Animal model; Gene knockout; Haemostasis; MRS2500; Platelet aggregation

Indexed keywords

4 (2 IODO 6 METHYLAMINO 9H PURIN 9 YL) 2 PHOSPHONOOXYBICYCLO[3.1.0]HEXANE 1 METHANOL; CLOPIDOGREL; FERROUS CHLORIDE; PURINERGIC P2Y1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING TIME; CAVA VEIN; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; GENE DELETION; KIDNEY HEMORRHAGE; MALE; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; PATHOGENESIS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RECEPTOR BLOCKING; TAIL; THROMBOCYTE AGGREGATION; VEIN THROMBOSIS; VENA CAVA THROMBOSIS;

ANIMALS; BLOOD PLATELETS; CHLORIDES; DEOXYADENINE NUCLEOTIDES; FERRIC COMPOUNDS; GENE DELETION; MICE; MICE, KNOCKOUT; NOXAE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RECEPTORS, PURINERGIC P2Y1; VENAE CAVAE; VENOUS THROMBOSIS;

EID: 84865145364     PISSN: 09295305     EISSN: 1573742X     Source Type: Journal    
DOI: 10.1007/s11239-012-0745-3     Document Type: Article

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