γ-Glutamyl cysteine and γ-glutamyl valine inhibit TNF-α signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1852, Issue 5, 2015, Pages 792-804

  Zhang, Hua ^a   Kovacs Nolan, Jennifer ^a   Kodera, Tomohiro ^b   Eto, Yuzuru ^b   Mine, Yoshinori ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b AJINOMOTO CO INC   (Japan)

Author keywords

Calcium sensing receptor (CaSR); Dextran sodium sulfate (DSS) colitis; Inflammatory bowel disease (IBD); Intestinal epithelium; Tumor necrosis factor (TNF); Glutamyl dipeptides

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AGENTS USED IN INFLAMMATORY BOWEL DISEASE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BETA ARRESTIN 2; CALCIUM SENSING RECEPTOR; CHEMOKINE; CYTOKINE; DEXTRAN SULFATE; DIPEPTIDE DERIVATIVE; GAMMA GLUTAMYLCYSTEINE; GAMMA GLUTAMYLVALINE; GAMMA INTERFERON; I KAPPA B ALPHA; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG; AUTACOID; BETA ARRESTIN; DIPEPTIDE; GAMMA-GLUTAMYLCYSTEINE; GAMMA-GLUTAMYLVALINE; RETINA S ANTIGEN; TUMOR NECROSIS FACTOR RECEPTOR;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CACO 2 CELL LINE; CLINICAL FEATURE; COLON; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DEXTRAN SODIUM SULFATE-INDUCED COLITIS; DOSE RESPONSE; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE EPITHELIUM CELL; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TREATMENT RESPONSE; WEIGHT REDUCTION; ANIMAL; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; COLITIS; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; GENETICS; INTESTINE; METABOLISM; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ALLOSTERIC REGULATION; ANIMALS; ARRESTINS; BLOTTING, WESTERN; CACO-2 CELLS; COLITIS; CYTOKINES; DEXTRAN SULFATE; DIPEPTIDES; EPITHELIAL CELLS; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTESTINES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE, INBRED BALB C; PHOSPHORYLATION; RECEPTORS, CALCIUM-SENSING; RECEPTORS, TUMOR NECROSIS FACTOR; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84922351579     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.12.023     Document Type: Article

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