NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth

Cancer Discovery

Volumn 5, Issue 2, 2015, Pages 182-197

  Kangsamaksin, Thaned ^a,b   Murtomaki, Aino ^a,c   Kofler, Natalie M ^a   Cuervo, Henar ^a   Chaudhri, Reyhaan A ^a   Tattersall, Ian W ^a   Rosenstiel, Paul E ^a   Shawber, Carrie J ^a   Kitajewski, Jan ^a  

^a NewYork Presbyterian Hospital   (United States)

^b MAHIDOL UNIVERSITY   (Thailand)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; DELTA LIKE LIGAND; JAGGED1; LIGAND; NOTCH INHIBITOR; NOTCH RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; NOTCH1 RECEPTOR; PROTEIN BINDING; SIGNAL PEPTIDE;

ANGIOGENESIS; ANGIOGENESIS ASSAY; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; CANCER CELL; CANCER INHIBITION; CELL INTERACTION; DRUG EFFICACY; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING; LIGAND BINDING; MOUSE; NEWBORN; NONHUMAN; PERICYTE; PROTEIN DOMAIN; REAL TIME POLYMERASE CHAIN REACTION; RETINA; TUMOR GROWTH; TUMOR VASCULARIZATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMISTRY; GENETICS; METABOLISM; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; SIGNAL TRANSDUCTION; VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; FEMALE; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN BINDING; RECEPTOR, NOTCH1; RECEPTORS, NOTCH; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 84922340800     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-14-0650     Document Type: Article

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