B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma/polyp (SSA/P) and cancer in SSA/P

British Journal of Cancer

Volumn 112, Issue 2, 2015, Pages 403-412

  Inoue, A ^a   Okamoto, K ^a   Fujino, Y ^a   Nakagawa, T ^a   Muguruma, N ^a   Sannomiya, K ^a   Mitsui, Y ^a   Takaoka, T ^a   Kitamura, S ^a   Miyamoto, H ^a   Okahisa, T ^a   Fujimori, T ^b   Imoto, I ^a   Takayama, T ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

ACF; Colon cancer; DNA methylation; SSA P

Indexed keywords

B RAF KINASE; GENOMIC DNA; K RAS PROTEIN; PROTEIN P53; BRAF PROTEIN, HUMAN;

ABERRANT CRYPT FOCUS; ADULT; ARTICLE; CANCER GENETICS; CANCER PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; DNA METHYLATION; FEMALE; FLI1 GENE; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CORRELATION; GJA3 GENE; HDHD3 GENE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAGNIFYING ENDOSCOPY; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MLH1 GENE; POINT MUTATION; POLYMERASE CHAIN REACTION; PQLC1 GENE; PRECANCER AND CANCER-IN-SITU; PREVALENCE; PRIORITY JOURNAL; RASL10B GENE; RECTUM ADENOMA; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SESSILE SERRATED ADENOMA POLYP; SLC26A2 GENE; TUMOR BIOPSY; ADENOMA; AGED; CASE CONTROL STUDY; COLON TUMOR; GENETIC PREDISPOSITION; GENETICS; MISSENSE MUTATION;

ABERRANT CRYPT FOCI; ADENOMA; AGED; CASE-CONTROL STUDIES; COLONIC NEOPLASMS; DNA METHYLATION; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; MUTATION, MISSENSE; PROTO-ONCOGENE PROTEINS B-RAF;

EID: 84922337339     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2014.545     Document Type: Article

References (47)

1. Ban S, Mitomi H, Horiguchi H, Sato H, Shimizu M (2014) Adenocarcinoma arising in small sessile serrated adenoma/polyp (SSA/P) of the colon: clinicopathological study of eight lesions. Pathology International 64: 123-132.
2. Beggs AD, Jones A, Shepherd N, Arnaout A, Finlayson C, Abulafi AM, Morton DG, Matthews GM, Hodgson SV, Tomlinson IP (2013) Loss of expression and promoter methylation of SLIT2 are associated with sessile serrated adenoma formation. PLoS Genet 9: e1003488.
3. Banerjee D, Gakhar G, Madgwick D, Hurt A, Takemoto D, Nguyen TA (2010) A novel role of gap junction connexin46 protein to protect breast tumors from hypoxia. Int J Cancer 127: 839-848.
4. Bettington M, Walker N, Clouston A, Brown I, Leggett B, Whitehall V (2013) The serrated pathway to colorectal carcinoma: current concepts and challenges. Histopathology 62 : 367-386.
5. Bird RP (1987) Observations and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett 37: 147-151.
6. Brinkhuizen T, van den Hurk K, Winnepenninckx VJ, Hoon JP, van Marion AM, Veeck J, van Engeland M, van Steensel MA (2012) Epigenetic changes in Basal Cell Carcinoma affect SHH and WNT signaling components. PLoS One 7: e51710.
7. Cho NL, Redston M, Zauber AG, Carothers AM, Hornick J, Wilton A, Sontag S, Nishioka N, Giardiello FM, Saltzman JR, Gostout C, Eagle CJ, Hawk ET, Bertagnolli MM (2008) Aberrant crypt foci in the adenoma prevention with celecoxib trial. Cancer Prev Res (Phila Pa) 1: 21-31.
8. Cunningham JM, Christensen ER, Tester DJ, Kim CY, Roche PC, Burgart LJ, Thibodeau SN (1998) Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res 58: 3455-3460.
9. Dote H, Tsukuda K, Toyooka S, Yano M, Pass HI, Shimizu N (2004) Mutation analysis of the BRAF codon 599 in malignantpleural mesothelioma by enriched PCR-RFLP. Oncol Rep. 11: 361-363.
10. Drew DA, Devers TJ, O'Brien MJ, Horelik NA, Levine J, Rosenberg DW (2014) HD chromoendoscopy coupled with DNA mass spectrometry profiling identifies somatic mutations in microdissected human proximal aberrant crypt foci. Mol Cancer Res 12: 823-829.
11. Fujita K, Yamamoto H, Matsumoto T, Hirahashi M, Gushima M, Kishimoto J, Nishiyama K, Taguchi T, Yao T, Oda Y (2011) Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study. Am J Surg Pathol 35: 295-304.
12. Gaiser T, Meinhardt S, Hirsch D, Killian JK, Gaedcke J, Jo P, Ponsa I, Miró R, Rüschoff J, Seitz G, Hu Y, Camps J, Ried T (2013) Molecular patterns in the evolution of serrated lesion of the colorectum. Int J Cancer 132: 1800-1810.
13. Haila S, Hästbacka J, Böhling T, Karjalainen-Lindsberg ML, Kere J, Saarialho-Kere U (2001) SLC26A2 (diastrophic dysplasia sulfate transporter) is expressed in developing and mature cartilage but also in other tissues and cell types. J Histochem Cytochem 49: 973-982.
14. Hatada I, Fukasawa M, Kimura M, Morita S, Yamada K, Yoshikawa T, Yamanaka S, Endo C, Sakurada A, Sano M, Kondo T, Horii A, Ushijima T, Sasaki H (2006) Genome-wide profiling of promoter methylation inhuman. Oncogene 25: 3059-3064.
15. Higuchi T, Sugihara K, Jass JR (2005) Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology 47: 32-40.
16. Horii T, Morita S, Kimura M, Izuho H (2009) Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF. PLoS One 4: e5809.
17. Hsieh CL, Kumar NM, Gilula NB, Francke U (1991) Distribution of genes for gap junction membrane channel proteins on human and mouse chromosomes. Somat Cell Mol Genet 17: 191-200.
18. Huang CS, Farraye FA, Yang S, O'Brien MJ (2011) The clinical significance of serrated polyps. Am J Gastroenterol 106: 229-240.
19. Hurlstone DP, Karajeh M, Sanders DS, Drew SK, Cross SS (2005) Rectal aberrant crypt foci identified using high-magnification-chromoscopic colonoscopy: biomarkers for flat and depressed neoplasia. Am J Gastroenterol 100: 1283-1289.
20. Jass JR, Baker K, Zlobec I, Higuchi T, Barker M, Buchanan D, Young J (2006) Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer. Histopathology 49: 121-131.
21. Kaji E, Uraoka T, Kato J, Hiraoka S, Suzuki H, Akita M, Saito S, Tanaka T, Ohara N, Yamamoto K (2012) Externalization of saw-tooth architecture in small serrated polyps implies the presence of methylation of IGFBP7. Dig Dis Sci. 57: 1261-1270.
22. Kambara T, Simms LA, Whitehall VL, Spring KJ, Wynter CV, Walsh MD, Baeker MA, Arnold S, McGivern A, Matsubara N, Tanaka N, Higuchi T, Young J, Jass JR, Leggett BA (2004) BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 53: 1137-1144.
23. Kim J, Ng J, Arozulllah A, Ewing R, Llor X, Carroll RE, Benya RV (2008) Aberrant crypt focus size predicts distal polyp histopathology. Cancer Epidemiol Biomarkers Prev 17: 1155-1162.
24. Kim KM, Lee EJ, Ha S, Kang SY, Jang KT, Park CK, Kim JY, Kim YH, Chang DK, Odze RD (2011) Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea. Am J Surg Pathol 35: 1274-1286.
25. Kobayashi Y, Aizawa A, Takizawa T, Yoshizawa C, Horiguchi H, Ikeuchi Y, Kakegawa S, Watanabe T, Maruyama K, Morikawa A, Hatada I, Arakawa H (2012) DNA methylation changes between relapse and remission of minimal change nephrotic syndrome. Pediatr Nephrol 27: 2233-2241.
26. Kubo M, Czuwara-Ladykowska J, Moussa O, Markiewicz M, Smith E, Silver RM, Jablonska S, Blaszczyk M, Watson DK, Trojanowska M (2003) Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol 163: 571-581.
27. Lin ZY, Chuang WL (2012) Genes responsible for the characteristics of primary cultured invasive phenotype hepatocellular carcinoma cells. Biomed Pharmacother 66: 454-458.
28. Maeda T, Suzuki K, Togashi K, Nokubi M, Saito M, Tsujinaka S, Kamiyama H, Konishi F (2011) Sessile serrated adenoma shares similar genetic and epigenetic features with microsatellite unstable colon cancer in a location-dependent manner. Exp Ther Med 2: 695-700.
29. May WA, Lessnick SL, Braun BS, Klemsz M, Lewis BC, Lunsford LB, Hromas R, Denny CT (1993) The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. Mol Cell Biol 13: 7393-7398.
30. Miyanishi K, Takayama T, Ohi M, Hayashi T, Nobuoka A, Nakajima T, Takimoto R, Kogawa K, Kato J, Sakamaki S, Niitsu Y (2001) Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis. Gastroenterology 121: 865-874.
31. Mutch MG, Schoen RE, Fleshman JW, Rall CJ, Dry S, Seligson D, Charabaty A, Chia D, Umar A, Viner J, Hawk E, Pinsky PF (2009) A multicenter study of prevalence and risk factors for aberrant crypt foci. Clin Gastroenterol Hepatol 7: 568-574.
32. Nagasaka T, Sasamoto H, Notohara K, Cullings HM, Takeda M, Kimura K, Kambara T, MacPhee DG, Young J, Leggett BA, Jass JR, Tanaka N, Matsubara N (2004) Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. J Clin Oncol 22: 4584-4594.
33. O'Brien MJ, Yang S, Mack C, Xu H, Huang CS, Mulcahy E, Amorosino M, Farraye FA (2006) Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. Am J Surg Pathol 30: 1491-1501.
34. Oster B, Thorsen K, Lamy P, Wojdacz TK, Hansen LL, Birkenkamp-Demtröder K, Sørensen KD, Laurberg S, Orntoft TF, Andersen CL (2011) Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas. Int J Cancer 129: 2855-2866.
35. Roncucci L, Stamp D, Medline A, Cullen JB, Bruce WR (1991) Identification and quantification of aberrant crypt foci and microadenomas in the human colon. Hum Pathol 22: 287-294.
36. Seike K, Koda K, Oda K, Kosugi C, Shimizu K, Nishimura M, Shioiri M, Takano S, Ishikura H, Miyazaki M (2006) Assessment of rectal aberrant crypt foci by standard chromoscopy and its predictive value for colonic advanced neoplasms. Am J Gastroenterol 101: 1362-1369.
37. Sentani K, Oue N, Sakamoto N, Anami K, Naitou Y, Aoyagi K, Sasaki H, Yasui W (2010) Upregulation of connexin 30 in intestinal phenotype gastric cancer and its reduction during tumor progression. Pathobiology 77: 241-248.
38. Snover DC, Ahnen DJ, Burt RW (2010) Serrated polyps of the colon and rectum and serrated polyposis. In Bosman FT, Carneiro F, Hruban RH, Theise ND (eds). WHO classification of tumours of the digestive system. IARC P: Lyon, France, pp 160-165.
39. Shpitz B, Bomstein Y, Mekori Y, Cohen R, Kaufman Z, Neufeld D, Galkin M, Bernheim J (1998) Aberrant crypt foci in human colons: distribution and histomorphologic characteristics. Hum Pathol 29: 469-475.
40. Spring KJ, Zhao ZZ, Karamatic R, Walsh MD, Whitehall VL, Pike T, Simms LA, Young J, James M, Montgomery GW, Appleyard M, Hewett D, Togashi K, Jass JR, Leggett BA (2006) High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology 131: 1400-1407.
41. Takayama T, Katsuki S, Takahashi Y, Ohi M, Nojiri S, Sakamaki S, Kato J, Kogawa K, Miyake H, Niitsu Y (1998) Aberrant crypt foci of the colon as precursors of adenoma and cancer. N Engl J Med 339: 1277-1284.
42. Takayama T, Nagashima H, Maeda M, Nojiri S, Hirayama M, Nakano Y, Takahashi Y, Sato Y, Sekikawa H, Mori M, Sonoda T, Kimura T, Kato J, Niitsu Y (2011) Randomized double-blind trial of sulindac and etodolac to eradicate aberrant crypt foci and to prevent sporadic colorectal polyps. Clin Cancer Res 17: 3803-3811.
43. Takayama T, Ohi M, Hayashi T, Miyanishi K, Nobuoka A, Nakajima T, Satou T, Takimoto R, Kato J, Sakamaki S, Niitsu Y (2001) Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. Gastroenterology 121: 599-611.
44. Takayama T, Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y (2005) Aberrant crypt foci: detection, gene abnormalities, and clinical usefulness. Clin Gastroenterol Hepatol 3(7 Suppl 1): S42-S45.
45. You JF, Buhard O, Ligtenberg MJ, Kets CM, Niessen RC, Hofstra RM, Wagner A, Dinjens WN, Colas C, Lascols O, Collura A, Flejou JF, Duval A, Hamelin R (2010) Tumours with loss of MSH6 expression are MSI-H when screened with a pentaplex of five mononucleotide repeats. Br J Cancer 103: 1840-1845.
46. Yusa A, Miyazaki K, Kimura N, Izawa M, Kannagi R (2010) Epigenetic silencing of the sulfate transporter gene DTDST induces sialyl Lewisx expression and accelerates proliferation of colon cancer cells. Cancer Res 70: 4064-4073.
47. Zou H, Hu L, Li J, Zhan S, Cao K (2006) Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential. Biotechnol Lett 28: 1901-1908.