Adenocarcinoma arising in small sessile serrated adenoma/polyp (SSA/P) of the colon: Clinicopathological study of eight lesions

Pathology International

Volumn 64, Issue 3, 2014, Pages 123-132

  Ban, Shinichi ^a   Mitomi, Hiroyuki ^b   Horiguchi, Hisashi ^c   Sato, Hideaki ^a   Shimizu, Michio ^d  

^a Saiseikai Kawaguchi General Hospital   (Japan)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

^c HITACHI LTD   (Japan)

^d SAITAMA MEDICAL UNIVERSITY INTERNATIONAL MEDICAL CENTER   (Japan)

Author keywords

Adenocarcinoma; Colon; Immunohistochemistry; Sessile serrated adenoma polyp

Indexed keywords

MUCIN 2; MUCIN 5AC; MUCIN 6; PROTEIN MLH1; PROTEIN P53;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CANCER GROWTH; CLINICAL ARTICLE; COLON POLYP; DYSPLASIA; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; MALE; MIDDLE AGED; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM ADENOMA; STROMA; TUMOR INVASION; TUMOR VOLUME; VERY ELDERLY; WNT SIGNALING PATHWAY; COLON; COLON TUMOR; PATHOLOGY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; COLON; COLONIC NEOPLASMS; COLONIC POLYPS; FEMALE; HUMANS; MALE; MIDDLE AGED;

EID: 84897500769     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/pin.12147     Document Type: Article

References (27)

1. Hayashi T, Yatani R, Apostol J, Stemmermann GN. Pathogenesis of hyperplastic polyps of the colon: A hypothesis based on ultrastructural and in vitro cell kinetics. Gastroenterology 1974; 66: 347-356.
2. Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am J Surg Pathol 1990; 14: 524-537.
3. Snover DC, Ahnen DJ, Burt RW, Odze RD. Serrated polyps of the colon and rectum and serrated polyposis. In: Bosman FT, Carneiro F, Hruban RH, Theise ND, eds. WHO Classification of Tumours of the Digestive System. Lyon: IARC, 2010; 160-165.
4. Torlakovic E, Skovlund E, Snover DC, Torlakovic G, Nesland JM. Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol 2003; 27: 65-81.
5. Goldstein NS, Bhanot P, Odish E, Hunter S. Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas. Am J Clin Pathol 2003; 119: 778-796.
6. O'Brien MJ. Hyperplastic and serrated polyps of the colorectum. Gastroenterol Clin North Am 2007; 36: 947-968.
7. Snover DC. Update on the serrated pathway to colorectal carcinoma. Hum Pathol 2011; 42: 1-10.
8. Rex DK, Ahnen DJ, Baron JA etal. Serrated lesions of the colorectum: Review and recommendations from an expert panel. Am J Gastroenterol 2012; 107: 1315-1329.
9. Goldstein NS. Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: A study of eight cases. Am J Clin Pathol 2006; 125: 132-145.
10. Fujita K, Yamamoto H, Matsumoto T etal. Sessile serrated adenoma with early neoplastic progression: A clinicopathologic and molecular study. Am J Surg Pathol 2011; 35: 295-304.
11. Sheridan TB, Fenton H, Lewin MR etal. Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: An immunohistochemical study of serrated lesions 'caught in the act'. Am J Clin Pathol 2006; 126: 564-571.
12. Oh K, Redston M, Odze RD. Support for hMLH1 and MGMT silencing as a mechanism of tumorigenesis in the hyperplastic-adenoma-carcinoma (serrated) carcinogenic pathway in the colon. Hum Pathol 2005; 36: 101-111.
13. Patil DT, Shadrach BL, Rybicki LA, Leach BH, Pai RK. Proximal colon cancers and the serrated pathway: A systematic analysis of precursor histology and BRAF mutation status. Mod Pathol 2012; 25: 1423-1431.
14. Higuchi T, Sugihara K, Jass JR. Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology 2005; 47: 32-40.
15. Mäkinen MJ. Colorectal serrated adenocarcinoma. Histopathology 2007; 50: 131-150.
16. Oono Y, Fu K, Nakamura H etal. Progression of a sessile serrated adenoma to an early invasive cancer within 8 months. Dig Dis Sci 2009; 54: 906-909.
17. Fujimori Y, Fujimori T, Imura J etal. An assessment of the diagnostic criteria for sessile serrated adenoma/polyps: SSA/Ps using image processing software analysis for Ki67 immunohistochemistry. Diagn Pathol 2012; 7: 59.
18. Aust DE, Baretton GB. Members of the Working Group GI-Pathology of the German Society of Pathology. Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)-proposal for diagnostic criteria. Virchows Arch 2010; 457: 291-297.
19. Japanese Society for Cancer of the Colon and Rectum. Japanese Classification of Colorectal Carcinoma, 2nd English edn. Tokyo: Kanehara & Co., 2009.
20. Lash RH, Genta RM, Schuler CM. Sessile serrated adenomas: Prevalence of dysplasia and carcinoma in 2139 patients. J Clin Pathol 2010; 63: 681-686.
21. Jass JR, Do KA, Simms LA etal. Morphology of sporadic colorectal cancer with DNA replication errors. Gut 1998; 42: 673-679.
22. Alexander J, Watanabe T, Wu TT, Rashid A, Li S, Hamilton SR. Histopathological identification of colon cancer with microsatellite instability. Am J Pathol 2001; 158: 527-535.
23. Kimura T, Yamamoto E, Yamano HO etal. A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma. Am J Gastroenterol 2012; 107: 460-469.
24. Rosty C, Hewett DG, Brown IS, Leggett BA, Whitehall VL. Serrated polyps of the large intestine: Current understanding of diagnosis, pathogenesis, and clinical management. J Gastroenterol 2013; 48: 287-302.
25. Fujita K, Hirahashi M, Yamamoto H etal. Mucin core protein expression in serrated polyps of the large intestine. Virchows Arch 2010; 457: 443-449.
26. Owens SR, Chiosea SI, Kuan SF. Selective expression of gastric mucin MUC6 in colonic sessile serrated adenoma but not in hyperplastic polyp aids in morphological diagnosis of serrated polyps. Mod Pathol 2008; 21: 660-669.
27. Gibson JA, Hahn HP, Shahsafaei A, Odze RD. MUC expression in hyperplastic and serrated colonic polyps: Lack of specificity of MUC6. Am J Surg Pathol 2011; 35: 742-749.