HD chromoendoscopy coupled with DNA mass spectrometry profiling identifies somatic mutations in microdissected human proximal aberrant crypt foci

Molecular Cancer Research

Volumn 12, Issue 6, 2014, Pages 823-829

  Drew, David A ^a   Devers, Thomas J ^a   O'Brien, Michael J ^b   Horelik, Nicole A ^a   Levine, Joel ^a   Rosenberg, Daniel W ^a  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b BOSTON MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; FLT3 LIGAND;

ABERRANT CRYPT FOCUS; APC GENE; ARTICLE; ASCENDING COLON; CANCER DIAGNOSIS; CANCER LOCALIZATION; CHROMOENDOSCOPY; COLON CANCER; COLON CARCINOGENESIS; COLONOSCOPE; COLONOSCOPY; CONTROLLED STUDY; DESCENDING COLON; DNA MASS SPECTROMETRY; EPIDERMAL GROWTH FACTOR RECEPTOR GENE; FLT3 GENE; GENE; GENE DELETION; HIGH DEFINITION CHROMOENDOSCOPY; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; MICROARRAY ANALYSIS; MICRODISSECTION; PRIORITY JOURNAL; PROTO ONCOGENE; SOMATIC MUTATION; TUMOR BIOPSY; TUMOR SUPPRESSOR GENE; ABERRANT CRYPT FOCI; CHEMISTRY; COLORECTAL NEOPLASMS; GENETICS; IMMUNOHISTOCHEMISTRY; INTESTINE MUCOSA; MUTATION; PATHOLOGY; PROCEDURES;

ABERRANT CRYPT FOCI; COLONOSCOPY; COLORECTAL NEOPLASMS; DNA, NEOPLASM; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MASS SPECTROMETRY; MICRODISSECTION; MUTATION;

EID: 84902682625     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-13-0624     Document Type: Article

References (24)

1. Rougier P, Mitry E. Epidemiology, treatment and chemoprevention in colorectal cancer. Ann Oncol 2003;14 Suppl 2:ii3-5. (Pubitemid 36874131)
2. Baxter NN, Goldwasser MA, Paszat LF, Saskin R, Urbach DR, Rabeneck L. Association of colonoscopy and death from colorectal cancer. Ann Intern Med 2009;150:1-8.
3. Cooper GS, Xu F, Barnholtz Sloan JS, Schluchter MD, Koroukian SM. Prevalence and predictors of interval colorectal cancers in medicare beneficiaries. Cancer 2012;118:3044-52.
4. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
5. Bird RP. Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett 1987;37:147-51. (Pubitemid 17157833)
6. Yokota T, Sugano K, Kondo H, Saito D, Sugihara K, Fukayama N, et al. Detection of aberrant crypt foci by magnifying colonoscopy. Gastrointest Endosc 1997;46:61- 5.
7. Greenspan EJ, Jablonski MA, Rajan TV, Levine J, Belinsky GS, Rosenberg DW. Epigenetic alterations in RASSF1A in human aberrant crypt foci. Carcinogenesis 2006;27:1316-22. (Pubitemid 43985406)
8. Lance P, Hamilton SR. Sporadic aberrant crypt foci are not a surrogate endpoint for colorectal adenoma prevention. Cancer Prev Res 2008;1:4-8.
9. Stevens RG, Pretlow TP, Hurlstone DP, Giardina C, Rosenberg DW. Comment re: "Sporadic aberrant crypt foci are not a surrogate end-point for colorectal adenoma prevention" and "Aberrant crypt foci in the adenoma prevention with celecoxib trial". Cancer Prev Res 2008;1:215-6.
10. Anderson JC, Swede H, Rustagi T, Protiva P, Pleau D, Brenner BM, et al. Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. Cancer Causes Control 2012;23:355-61.
11. Drew DA, Devers T, Horelik N, Yang S, O'Brien M, Wu R, et al. Nanoproteomic analysis of extracellular receptor kinase-1/2 posttranslational activation in microdissected human hyperplastic colon lesions. Proteomics 2013;13:1428-36.
12. Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ. BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am J Surg Pathol 2004;28:1452-9. (Pubitemid 39425511)
13. Fumagalli D, Gavin PG, Taniyama Y, Kim SI, Choi HJ, Paik S, et al. A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes. BMC Cancer 2010;10:101.
14. Rosenberg DW, Yang S, Pleau DC, Greenspan EJ, Stevens RG, Rajan TV, et al. Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans. Cancer Res 2007;67:3551-4. (Pubitemid 46762136)
15. Takayama T, Ohi M, Hayashi T, Miyanishi K, Nobuoka A, Nakajima T, et al. Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. Gastroenterology 2001;121:599-611. (Pubitemid 32822575)
16. Network TCGA. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012;487:330-7.
17. Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T. Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res 2004;64:8919-23. (Pubitemid 39665498)
18. Grundler R, Thiede C, Miething C, Steudel C, Peschel C, Duyster J. Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor. Blood 2003;102:646-51. (Pubitemid 36841987)
19. Miyaki M, Konishi M, Kikuchi-Yanoshita R, Enomoto M, Igari T, Tanaka K, et al. Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res 1994;54: 3011-20. (Pubitemid 24187789)
20. Aretz S, Stienen D, Uhlhaas S, Pagenstecher C, Mangold E, Caspari R, et al. Large submicroscopic genomic APC deletions are a common cause of typical familial adenomatous polyposis. J Med Genet 2005;42:185-92. (Pubitemid 40204375)
21. Kanter-Smoler G, Fritzell K, Rohlin A, Engwall Y, Hallberg B, Bergman A, et al. Clinical characterization and the mutation spectrum in Swedish adenomatous polyposis families. BMC Med 2008;6:10.
22. Siu IM, Robinson DR, Schwartz S, Kung HJ, Pretlow TG, Petersen RB, et al. The identification of monoclonality in human aberrant crypt foci. Cancer Res 1999;59:63-6. (Pubitemid 29062957)
23. Greenspan EJ, Cyr JL, Pleau DC, Levine J, Rajan TV, Rosenberg DW, et al. Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer. Carcinogenesis 2007;28:769-76. (Pubitemid 46523333)
24. De Rosa M, Scarano MI, Panariello L, Morelli G, Riegler G, Rossi GB, et al. The mutation spectrum of the APC gene in FAP patients from southern Italy: detection of known and four novel mutations. Hum Mutat 2003;21:655-6.