Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis

Journal of Biological Chemistry

Volumn 290, Issue 6, 2015, Pages 3430-3439

  Jepsen, Malene R ^a   Kløverpris, Søren ^a   Mikkelsen, Jakob H ^a   Pedersen, Josefine H ^a   Füchtbauer, Ernst Martin ^a   Laursen, Lisbeth S ^a   Oxvig, Claus ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

COVALENT BONDS; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOLOGY; INSULIN; PROTEINS; TISSUE;

INSULIN-LIKE GROWTH FACTOR; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PROTEINASE INHIBITORS; PROTEOLYTIC ACTIVITIES; PROTEOLYTIC INHIBITIONS; RECEPTOR SIGNALING; TRANSGENIC EXPRESSION;

MAMMALS;

ALANINE; CYSTEINE; GLYCOPROTEIN; METALLOPROTEINASE; PREGNANCY ASSOCIATED PLASMA PROTEIN A; PROTEIN STC2; PROTEIN VARIANT; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN RECEPTOR; UNCLASSIFIED DRUG; PROTEIN BINDING; SOMATOMEDIN C RECEPTOR; STC2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COVALENT BOND; DISULFIDE BOND; EMBRYO; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MAMMAL; METABOLIC INHIBITION; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; CELL CULTURE; CHEMISTRY; GENETICS; GROWTH; HEK293 CELL LINE; METABOLISM; MOLECULAR GENETICS; MUTATION;

MAMMALIA; MUS; MUS MUSCULUS;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CYSTEINE; FEMALE; GLYCOPROTEINS; GROWTH; HEK293 CELLS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4; MALE; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PROTEIN BINDING; PROTEOLYSIS; RECEPTOR, IGF TYPE 1;

EID: 84922324488     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.611665     Document Type: Article

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