Pregnancy-Associated Plasma Protein-A2 (PAPP-A2): Tissue expression and biological consequences of gene knockout in mice

Endocrinology

Volumn 152, Issue 7, 2011, Pages 2837-2844

  Conover, Cheryl A ^a   Boldt, Henning B ^a,c   Bale, Laurie K ^a   Clifton, Kari B ^a   Grell, Jacquelyn A ^a   Mader, Jessica R ^a   Mason, Emily J ^a   Powell, David R ^b  

^a MAYO CLINIC   (United States)

^b LEXICON PHARMACEUTICALS INC   (United States)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PREGNANCY ASSOCIATED PLASMA PROTEIN A; PREGNANCY ASSOCIATED PLASMA PROTEIN A2; SOMATOMEDIN BINDING PROTEIN 5; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY HEIGHT; BONE DENSITY; BRAIN; CALVARIA; COLON; CONTROLLED STUDY; FEMALE; FEMUR; FERTILITY; FIBROBLAST; GENE INACTIVATION; GROWTH RETARDATION; KIDNEY; LUNG; MALE; MENDELIAN RANDOMIZATION ANALYSIS; MOUSE; NONHUMAN; OVARY; PLACENTA; POSTNATAL GROWTH; PRIORITY JOURNAL; PROSTATE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RNA ISOLATION; SPINAL CORD; TESTIS; TIBIA;

ANIMALS; BODY WEIGHT; BONE DEVELOPMENT; CELLS, CULTURED; EMBRYO, MAMMALIAN; FEMALE; GENE EXPRESSION; HETEROZYGOTE; HYDROLYSIS; INFERTILITY; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5; ISOENZYMES; MALE; METALLOENDOPEPTIDASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SPECIFICITY; PREGNANCY; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; RNA, MESSENGER; SEX CHARACTERISTICS;

EID: 79959389121     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2011-0036     Document Type: Article

References (38)

1. Farr M, Strübe J, Geppert HG, Kocourek A, Mahne M, Tschesche H 2000 Pregnancy-associated plasma protein-E. Biochim Biophys Acta 1493:356-362
2. Boldt HB, Overgaard MT, Laursen LS, Weyer K, Sottrup-Jensen L, Oxvig C 2001 Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin. Biochem J 358:359-367 (Pubitemid 32826352)
3. Overgaard MT, Boldt HB, Laursen LS, Sottrup-Jensen L, Conover CA, Oxvig C 2001 Pregnancy-associated plasma protein-A2 (PAPPA2), a novel insulin-like growth factor binding protein-5 proteinase. J Biol Chem 276:21849-21853
4. Page NM, Butlin DJ, Lomthaisong K, Lowry PJ 2001 The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant. Placenta 22:681-687 (Pubitemid 32982704)
5. Lin TM, Galbert SP, Kiefer D, Spellacy WN, Gall S 1974 Characterization of four human pregnancy-associated plasma proteins. Am J Obstet Gynecol 118:223-236
6. Boldt HB, Conover CA 2007 Pregnancy-associated plasma protein- A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs. Growth Horm IGF Res 17:10-18
7. Harrington SC, Simari RD, Conover CA 2007 Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. Circ Res 100:1696-1702 (Pubitemid 46987861)
8. Tanner SJ, Hefferan TE, Rosen CJ, Conover CA 2008 Impact of pregnancy-associated plasma protein-A deletion on the adult murine skeleton. J Bone Miner Res 23:655-662 (Pubitemid 351575019)
9. Miller BS, Bronk JT, Nishiyama T, Yamagiwa H, Srivastava A, Bolander ME, Conover CA 2007 Pregnancy associated plasma protein- A is necessary for expeditious fracture healing in mice. J Endocrinol 192:505-513 (Pubitemid 46455955)
10. Qin X, Wergedal JE, Rehage M, Tran K, Newton J, Lam P, Baylink DJ, Mohan S 2006 Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo. Endocrinology 147:5653-5661 (Pubitemid 44833482)
11. Resch ZT, Simari RD, Conover CA 2006 Targeted disruption of the pregnancy-associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury. Endocrinology 147:5634-5640 (Pubitemid 44833480)
12. Boldt HB, Kjaer-Sorensen K, Overgaard MT, Weyer K, Poulsen CB, Sottrup-Jensen L, Conover CA, Giudice LC, Oxvig C 2004 The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity. J Biol Chem 279: 38525-38531 (Pubitemid 39296006)
13. Weyer K, Boldt HB, Poulsen CB, Kjaer-Sorensen K, Gyrup C, Oxvig C 2007 A substrate specificity-determining unit of three Lin12- notch repeat modules is formed in trans within the pappalysin-1 dimer and requires a sequence stretch C-terminal to the third module. J Biol Chem 282:10988-10999 (Pubitemid 47100765)
14. Weyer K, Overgaard MT, Laursen LS, Nielsen CG, Schmitz A, Christiansen M, Sottrup-Jensen L, Giudice LC, Oxvig C 2004 Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP module. Eur J Biochem 271:1525-1535 (Pubitemid 38553558)
15. Sun IY, Overgaard MT, Oxvig C, Giudice LC 2002 Pregnancy-associated plasma protein A proteolytic activity is associated with the human placental trophoblast cell membrane. J Clin Endocrinol Metab 87:5235-5240 (Pubitemid 35316369)
16. Conover CA, Harrington SC, Bale LK, Oxvig C 2007 Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages. Am J Physiol Heart Circ Physiol 292:H994-H1000
17. Laursen LS, Overgaard MT, Weyer K, Boldt HB, Ebbesen P, Christiansen M, Sottrup-Jensen L, Giudice LC, Oxvig C 2002 Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. J Biol Chem 277:47225-47234
18. Ortiz CO, Chen BK, Bale LK, Overgaard MT, Oxvig C, Conover CA 2003 Transforming growth factor-α regulation of the insulinlike growth factor binding protein-4 protease system in cultured human osteoblasts. J Bone Miner Res 18:1066-1072 (Pubitemid 37294944)
19. Byun D, Mohan S, Yoo M, Sexton C, Baylink DJ, Qin X 2001 Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro. J Clin Endocrinol Metab 86:847-854 (Pubitemid 32207505)
20. Conover CA, Bale LK, Overgaard MT, Johnstone EW, Laursen UH, Fuchtbauer E-M, Oxvig C, van Deursen J 2004 Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development. Development 131:187-1194
21. Schneider MR, Wolf E, Hoeflich A, Lahm H 2002 IGF-binding protein-5: flexible player in the IGF system and effector on its own. J Endocrinol 172:423-440 (Pubitemid 34232684)
22. Chari R, Lonergan KM, Pikor LA, Coe BP, Zhu CQ, Chan TH, MacAulay CE, Tsao MS, Lam S, NgRT, Lam WL 2010 A sequence-based approach to identify reference genes for gene expression analysis. BMC Med Genomics 3:32
23. McClive PJ, Sinclair AH 2001 Rapid DNA extraction and PCR-sexing of mouse embryos. Mol Reprod Dev 60:225-226 (Pubitemid 32847133)
24. Wang J, Qiu Q, Haider M, Bell M, Gruslin A, Christians JK 2009 Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse. J Endocrinol 202:337-345
25. Qin X, Sexton C, Byun D, Strong DD, Baylink DJ, Mohan S 2002 Differential regulation of pregnancy associated plasma protein (PAPP)-A during pregnancy in human and mouse. Growth Horm IGF Res 12:359-366 (Pubitemid 35238096)
26. Rivera GM, Fortune JE 2003 Selection of the dominant follicle and insulin-like growth factor (IGF)-binding proteins: evidence that pregnancy-associated plasma protein A contributes to proteolysis of IGF-binding protein 5 in bovine follicular fluid. Endocrinology 144: 437-446 (Pubitemid 36205213)
27. Nishizawa H, Pryor-Koishi K, Suzuki M, Kato T, Kogo H, Sekiya T, Kurahashi H, Udagawa Y 2008 Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients. Mol Hum Reprod 14:595-602
28. Buimer M, Keijser R, Jebbink JM, Wehkamp D, van Kampen AH, Boer K, van der Post JA, Ris-Stalpers C 2008 Seven placental transcripts characterize HELLP-syndrome. Placenta 29:444-453
29. Yan X, Baxter RC, Firth SM 2010 Involvement of pregnancy-associated plasma protein-A2 in insulin-like growth factor (IGF) binding protein-5 proteolysis during pregnancy: a potential mechanism for increasing IGF bioavailability. J Clin Endocrinol Metab 95: 1412-1420
30. Wald NJ, Watt HC, Hackshaw AK 1999 Integrated screening for Down's syndrome based on tests performed during the first and second trimesters. N Engl J Med 341:461-467 (Pubitemid 29372885)
31. Smith GC, Stenhouse EJ, Crossley JA, Aitken DA, Cameron AD, Connor JM 2002 Early-pregnancy origins of low birth weight. Nature 417:916 (Pubitemid 34716861)
32. Smith GC, Stenhouse EJ, Crossley JA, Aitken DA, Cameron AD, Connor JM 2002 Early pregnancy levels of pregnancy-associated plasma protein A and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth. J Clin Endocrinol Metab 87:1762-1767 (Pubitemid 34615266)
33. Wagner PK, Christians JK 2010 Altered placental expression of PAPPA2 does not affect birth weight in mice. Reprod Biol Endocrinol 8:90-97
34. Gilpin BJ, Loechel F, Mattei MG, Engvall E, Albrechtsen R, Wewer UM 1998 A novel, secreted form of human ADAM 12 (meltrin α) provokes myogenesis in vivo. J Biol Chem 273:157-166 (Pubitemid 28042189)
35. Loechel F, Fox JW, Murphy G, Albrechtsen R, Wewer UM 2000 ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3. Biochem Biophys Res Commun 278:511-515
36. Christians JK, Hoeflich A, Keightley PD 2006 PAPPA2, an enzyme that cleaves an insulin-like growth-factor-binding protein, is a candidate gene for a quantitative trait locus affecting body size in mice. Genetics 173:1547-1553 (Pubitemid 44127657)
37. Kiepe D, Ciarmatori S, Haarmann A, Tönshoff B 2006 Differential expression of IGF system components in proliferating vs. differentiating growth plate chondrocytes: the functional role of IGFBP-5. Am J Physiol Endocrinol Metab 290:E363-E371
38. Mohan S, Masinde G, Li X, Baylink DJ 2003 Mapping quantitative trait loci that influence serum insulin-like growth factor binding protein-5 levels in F2 mice 9MRL/MpJ X SJL/J). Endocrinology 144:3491-3496 (Pubitemid 36904427)