Correction: Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye (Proceedings of the National Academy of Sciences of the United States of America (2015) 112, 5, (1565-1570) DOI: 10.1073/pnas.1413347112);Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 5, 2015, Pages 1565-1570

  Thompson, Richard B ^a   Reffatto, Valentina ^b   Bundy, Jacob G ^c   Kortvely, Elod ^d   Flinn, Jane M ^e   Lanzirotti, Antonio ^f   Jones, Emrys A ^c   McPhail, David S ^c   Fearn, Sarah ^c   Boldt, Karsten ^d   Ueffing, Marius ^d   Ratu, Savanjeet Guy Singh ^b   Pauleikhoff, Laurenz ^b   Bird, Alan C ^b   Lengyel, Imre ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^e GEORGE MASON UNIVERSITY   (United States)

^f UNIVERSITY OF CHICAGO   (United States)

Author keywords

Age related macular degeneration; Calcium; Drusen; Hydroxyapatite; Retinal pigment epithelium

Indexed keywords

AMYLOID BETA PROTEIN; CALCIUM PHOSPHATE; CHOLESTEROL; COMPLEMENT FACTOR H; ELASTIN; FAT DROPLET; FLUORESCENT DYE; HYDROXYAPATITE; VITRONECTIN; ZINC PHOSPHATE;

AGING; ARTICLE; BRUCH MEMBRANE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EYE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL CULTURE; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MASS SPECTROMETRY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN SECRETION; RETINA MACULA LUTEA; X RAY DIFFRACTION; METABOLISM;

AGING; DURAPATITE; EYE; HUMANS; MICROSCOPY, FLUORESCENCE; RETINAL PIGMENT EPITHELIUM; X-RAY DIFFRACTION;

EID: 84922263543     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1511664112     Document Type: Erratum

References (47)

1. Crabb JW, et al. (2002) Drusen proteome analysis: An approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci USA 99(23):14682-14687.
2. Pauleikhoff D, Harper CA, Marshall J, Bird AC (1990) Aging changes in Bruch's membrane. A histochemical and morphologic study. Ophthalmology 97(2):171-178.
3. Sarks SH (1976) Ageing and degeneration in the macular region: A clinico-pathological study. Br J Ophthalmol 60(5):324-341.
4. Bird AC (2010) Therapeutic targets in age-related macular disease. J Clin Invest 120(9):3033-3041.
5. Moore DJ, Hussain AA, Marshall J (1995) Age-related variation in the hydraulic conductivity of Bruch's membrane. Invest Ophthalmol Vis Sci 36(7):1290-1297.
6. Bird AC, Phillips RL, Hageman GS (2014) Geographic atrophy: A histopathological assessment. JAMA Ophthalmol 132(3):338-345.
7. Johnson LV, et al. (2011) Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration. Proc Natl Acad Sci USA 108(45):18277-18282.
8. Kunchithapautham K, Atkinson C, Rohrer B (2014) Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation. J Biol Chem 289(21):14534-14546.
9. Rudolf M, Seckerdieck K, Grisanti S, Curcio CA (2014) Internal structure consistent with remodelling in very small drusen, revealed by filipin histochemistry for esterified cholesterol. Br J Ophthalmol 98(5):698-702.
10. Curcio CA, Johnson M, Rudolf M, Huang JD (2011) The oil spill in ageing Bruch membrane. Br J Ophthalmol 95(12):1638-1645.
11. Curcio CA, Johnson M, Huang JD, Rudolf M (2010) Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration. J Lipid Res 51(3):451-467.
12. Rudolf M, Curcio CA (2009) Esterified cholesterol is highly localized to Bruch's membrane, as revealed by lipid histochemistry in wholemounts of human choroid. J Histochem Cytochem 57(8):731-739.
13. Curcio CA, Johnson M, Huang JD, Rudolf M (2009) Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins. Prog Retin Eye Res 28(6):393-422.
14. Miller JW (2013) Age-related macular degeneration revisited - Piecing the puzzle: The LXIX Edward Jackson memorial lecture. Am J Ophthalmol 155(1):1-35.e13.
15. Luibl V, et al. (2006) Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. J Clin Invest 116(2):378-385.
16. Russell SR, Mullins RF, Schneider BL, Hageman GS (2000) Location, substructure, and composition of basal laminar drusen compared with drusen associated with aging and age-related macular degeneration. Am J Ophthalmol 129(2):205-214.
17. Lengyel I, et al. (2007) High concentration of zinc in sub-retinal pigment epithelial deposits. Exp Eye Res 84(4):772-780.
18. Flinn JM, Kakalec P, Tappero R, Jones B, Lengyel I (2014) Correlations in distribution and concentration of calcium, copper and iron with zinc in isolated extracellular deposits associated with age-related macular degeneration. Metallomics 6(7):1223-1228.
19. Davis WL, Jones RG, Hagler HK (1981) An electron microscopic histochemical and analytical X-ray microprobe study of calcification in Bruch's membrane from human eyes. J Histochem Cytochem 29(5):601-608.
20. Vogt SD, et al. (2011) Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy. Exp Eye Res 93(4):413-423.
21. Raggatt LJ, Partridge NC (2010) Cellular and molecular mechanisms of bone remodeling. J Biol Chem 285(33):25103-25108.
22. van der Schaft TL, de Bruijn WC, Mooy CM, Ketelaars DA, de Jong PT (1992) Element analysis of the early stages of age-related macular degeneration. Arch Ophthalmol 110(3):389-394.
23. Skinner HC, Nalbandian J (1975) Tetracyclines and mineralized tissues: Review and perspectives. Yale J Biol Med 48(5):377-397.
24. Kovar JL, et al. (2011) Near-infrared-labeled tetracycline derivative is an effective marker of bone deposition in mice. Anal Biochem 416(2):167-173.
25. Vilmann H (1969) The in vivo staining of bone with alizarin red S. J Anat 105(Pt 3):533-545.
26. Rahn BA, Perren SM (1971) Xylenol orange, a fluorochrome useful in polychrome sequential labeling of calcifying tissues. Stain Technol 46(3):125-129.
27. Lengyel I, et al. (2004) Association of drusen deposition with choroidal intercapillary pillars in the aging human eye. Invest Ophthalmol Vis Sci 45(9):2886-2892.
28. Raggio CL, Boyan BD, Boskey AL (1986) In vivo hydroxyapatite formation induced by lipids. J Bone Miner Res 1(5):409-415.
29. Fletcher JS, Vickerman JC (2013) Secondary ion mass spectrometry: Characterizing complex samples in two and three dimensions. Anal Chem 85(2):610-639.
30. Wang L, et al. (2010) Abundant lipid and protein components of drusen. PLoS ONE 5(4):e10329.
31. Hageman GS, et al. (2005) A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 102(20):7227-7232.
32. Hageman GS, Mullins RF, Russell SR, Johnson LV, Anderson DH (1999) Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells. FASEB J 13(3):477-484.
33. Cummings LJ, Snyder MA, Brisack K (2009) Protein chromatography on hydroxyapatite columns. Methods Enzymol 463:387-404.
34. Anderson HC, Garimella R, Tague SE (2005) The role of matrix vesicles in growth plate development and biomineralization. Front Biosci 10:822-837.
35. Mullins RF, Russell SR, Anderson DH, Hageman GS (2000) Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 14(7):835-846.
36. Laird DF, Mucalo MR, Yokogawa Y (2006) Growth of calcium hydroxyapatite (Ca-HAp) on cholesterol and cholestanol crystals from a simulated body fluid: A possible insight into the pathological calcifications associated with atherosclerosis. J Colloid Interface Sci 295(2):348-363.
37. Bertazzo S, et al. (2013) Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification. Nat Mater 12(6):576-583.
38. Vingerling JR, et al. (1995) The prevalence of age-related maculopathy in the Rotterdam Study. Ophthalmology 102(2):205-210.
39. Jensen OA (1977) Bruch's membrane in pseudoxanthoma elasticum. Histochemical, ultrastructural, and x-ray microanalytical study of the membrane and angioid streak areas. Albrecht Von Graefes Arch Klin Exp Ophthalmol 203(3-4):311-320.
40. Ulshafer RJ, Allen CB, Nicolaissen B, Jr, Rubin ML (1987) Scanning electron microscopy of human drusen. Invest Ophthalmol Vis Sci 28(4):683-689.
41. Boskey AL, Posner AS (1976) Formation of hydroxyapatite at low supersaturation. J Phys Chem 80(1):40-45.
42. Rudolf M, et al. (2008) Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathy. Invest Ophthalmol Vis Sci 49(3):1200-1209.
43. Panorgias A, et al. (2013) Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy. Invest Ophthalmol Vis Sci 54(6):4372-4384.
44. Curcio CA, Medeiros NE, Millican CL (1998) The Alabama Age-Related Macular Degeneration Grading System for donor eyes. Invest Ophthalmol Vis Sci 39(7):1085-1096.
45. Hammersley AP (1998) FIT2D V9.129 Reference Manual V3.1. ESRF Internal Report, ESRF98HA01T.
46. Bendall SC, et al. (2008) Prevention of amino acid conversion in SILAC experiments with embryonic stem cells. Mol Cell Proteomics 7(9):1587-1597.
47. Gloeckner CJ, Boldt K, Ueffing M (2009) Strep/FLAG tandem affinity purification (SF-TAP) to study protein interactions. Curr Protoc Protein Sci, Chap 19:Unit 19.20.