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Volumn 64, Issue 1, 2015, Pages 65-71

Preventive effect of safranal against oxidative damage in aged male rat brain

Author keywords

Aged; Brain; Oxidative damage; Safranal

Indexed keywords

ANTIOXIDANT; CATALASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; SAFRANAL; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; CYCLOHEXENE DERIVATIVE; LIPID PEROXIDE; REACTIVE OXYGEN METABOLITE; TERPENE;

EID: 84922236256     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.14-0027     Document Type: Article
Times cited : (72)

References (44)
  • 1
    • 0030853911 scopus 로고    scopus 로고
    • Age-related changes in malondialdehyde and glutathione levels of gastric mocosa of the rats and effects of exogenous melatonin
    • A kbulut, H., Akbulut, K.G., and Gonul, B. 1997. Age-related changes in malondialdehyde and glutathione levels of gastric mocosa of the rats and effects of exogenous melatonin. Dig. Diss. Sci. 42: 1381-1382.
    • (1997) Dig. Diss. Sci , vol.42 , pp. 1381-1382
    • Akbulut, H.1    Akbulut, K.G.2    Gonul, B.3
  • 2
  • 3
    • 0036775134 scopus 로고    scopus 로고
    • Effect of DL-α-lipoic acid on the status of lipid peroxidation and protein oxidation in various brain regions of aged rats
    • [Medline] [CrossRef]
    • A rivazhagan, P., Thilakavathy, T., Ramanathan, K., Kuma ran, S., and Panneerselvam, C. 2002. Effect of DL-α-lipoic acid on the status of lipid peroxidation and protein oxidation in various brain regions of aged rats. J. Nutr. Biochem. 13: 619-624. [Medline] [CrossRef]
    • (2002) J. Nutr. Biochem , vol.13 , pp. 619-624
    • Arivazhagan, P.1    Thilakavathy, T.2    Ramanathan, K.3    Kumaran, S.4    Panneerselvam, C.5
  • 4
    • 67649829751 scopus 로고    scopus 로고
    • A metabolic and functional overview of brain aging linked to neurological disorders
    • [Medline] [CrossRef]
    • Baquer, N.Z., Taha, A., Kumar, P., McLean, P., Cowsik, S.M., Kale, R.K., Singh, R., and Sharma, D. 2009. A metabolic and functional overview of brain aging linked to neurological disorders. Biogerontology 10: 377-413. [Medline] [CrossRef]
    • (2009) Biogerontology , vol.10 , pp. 377-413
    • Baquer, N.Z.1    Taha, A.2    Kumar, P.3    McLean, P.4    Cowsik, S.M.5    Kale, R.K.6    Singh, R.7    Sharma, D.8
  • 5
    • 0025242056 scopus 로고
    • Anti-oxidant defences and peroxidation in liver and brain of aged rats
    • [Medline]
    • Barja de Quiroga, G., Pérez-Campo, R., and López Torres, M. 1990. Anti-oxidant defences and peroxidation in liver and brain of aged rats. Biochem. J. 272: 247-250. [Medline]
    • (1990) Biochem. J , vol.272 , pp. 247-250
    • Barja de Quiroga, G.1    Pérez-Campo, R.2    López Torres, M.3
  • 6
    • 73649194769 scopus 로고
    • Improved method for the determination of blood glutathione
    • [Medline]
    • Beutler, E., Duron, O., and Kelly, B.M. 1963. Improved method for the determination of blood glutathione. J. Lab. Clin. Med. 61: 882-888. [Medline]
    • (1963) J. Lab. Clin. Med , vol.61 , pp. 882-888
    • Beutler, E.1    Duron, O.2    Kelly, B.M.3
  • 7
    • 84865250865 scopus 로고    scopus 로고
    • Akt/GSK-3β/eNOS phosphorylation arbitrates safranal-induced myocardial protection against ischemia- reperfusion injury in rats
    • [Medline] [CrossRef]
    • Bharti, S., Golechha, M., Kumari, S., Siddiqui, K.M., and Arya, D.S. 2012. Akt/GSK-3β/eNOS phosphorylation arbitrates safranal-induced myocardial protection against ischemia- reperfusion injury in rats. Eur. J. Nutr. 51: 719-727. [Medline] [CrossRef]
    • (2012) Eur. J. Nutr , vol.51 , pp. 719-727
    • Bharti, S.1    Golechha, M.2    Kumari, S.3    Siddiqui, K.M.4    Arya, D.S.5
  • 8
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • [Medline] [CrossRef]
    • Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254. [Medline] [CrossRef]
    • (1976) Anal. Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 9
    • 84896137461 scopus 로고    scopus 로고
    • Analysis of the mineral composition of Italian saffron by ICP-MS and classification of geographical origin
    • [Medline] [CrossRef]
    • D 'Archivio, A.A., Giannitto, A., Incani, A., and Nisi, S. 2014 Analysis of the mineral composition of Italian saffron by ICP-MS and classification of geographical origin. Food Chem. 157: 485-489. [Medline] [CrossRef]
    • (2014) Food Chem , vol.157 , pp. 485-489
    • D'Archivio, A.A.1    Giannitto, A.2    Incani, A.3    Nisi, S.4
  • 10
    • 84876419141 scopus 로고    scopus 로고
    • Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver
    • [Medline] [CrossRef]
    • Farahmand, S.K., Samini, F., Samini, M., and Samarghandian, S. 2013. Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver. Biogerontology 14: 63-71. [Medline] [CrossRef]
    • (2013) Biogerontology , vol.14 , pp. 63-71
    • Farahmand, S.K.1    Samini, F.2    Samini, M.3    Samarghandian, S.4
  • 12
    • 38449123153 scopus 로고    scopus 로고
    • Effects of antioxidant supplementation on the aging process
    • [Medline]
    • Fusco, D., Colloca, G., Lo Monaco, M.R., and Cesari, M. 2007 Effects of antioxidant supplementation on the aging process. Clin. Interv. Aging 2: 377-387. [Medline]
    • (2007) Clin. Interv. Aging , vol.2 , pp. 377-387
    • Fusco, D.1    Colloca, G.2    Lo Monaco, M.R.3    Cesari, M.4
  • 13
    • 54149101887 scopus 로고    scopus 로고
    • [Chosen non-enzymatic substances that participate in a protection against overproduction of free radicals]
    • (in Polish) [Medline]
    • Gałecka, E., Mrowicka, M., Malinowska, K., and Gałecki, P. 2008. [Chosen non-enzymatic substances that participate in a protection against overproduction of free radicals]. Pol. Merkuriusz Lek. 25: 269-272 (in Polish). [Medline]
    • (2008) Pol. Merkuriusz Lek , vol.25 , pp. 269-272
    • Gałecka, E.1    Mrowicka, M.2    Malinowska, K.3    Gałecki, P.4
  • 14
    • 0036325318 scopus 로고    scopus 로고
    • Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: Effect of vanadate and fenugreek (Trigonellafoenum graecum)
    • [Medline] [CrossRef]
    • G enet, S., Kale, R.K., and Baquer, N.Z. 2002. Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: effect of vanadate and fenugreek (Trigonellafoenum graecum). Mol. Cell. Biochem. 236: 7-12. [Medline] [CrossRef]
    • (2002) Mol. Cell. Biochem , vol.236 , pp. 7-12
    • Genet, S.1    Kale, R.K.2    Baquer, N.Z.3
  • 15
    • 84862534161 scopus 로고    scopus 로고
    • Saffron as a source of novel acetylcholinesterase inhibitors: Molecular docking and in vitro enzymatic studies
    • [Medline] [CrossRef]
    • G eromichalos, G.D., Lamari, F.N., Papandreou, M.A., Trafalis, D.T., Margarity, M., Papageorgiou, A., and Sinakos, Z. 2012. Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies. J. Agric. Food Chem. 60: 6131-6138. [Medline] [CrossRef]
    • (2012) J. Agric. Food Chem , vol.60 , pp. 6131-6138
    • Geromichalos, G.D.1    Lamari, F.N.2    Papandreou, M.A.3    Trafalis, D.T.4    Margarity, M.5    Papageorgiou, A.6    Sinakos, Z.7
  • 16
    • 84887576750 scopus 로고    scopus 로고
    • Brain aging, memory impairment and oxidative stress: A study in Drosophila melanogaster
    • [Medline] [Cross- Ref]
    • H addadi, M., Jahromi, S.R., Sagar, B.K., Patil, R.K., Shivanandappa, T., and Ramesh, S.R. 2014. Brain aging, memory impairment and oxidative stress: a study in Drosophila melanogaster. Behav. Brain Res. 259: 60-69. [Medline] [Cross- Ref]
    • (2014) Behav. Brain Res , vol.259 , pp. 60-69
    • Haddadi, M.1    Jahromi, S.R.2    Sagar, B.K.3    Patil, R.K.4    Shivanandappa, T.5    Ramesh, S.R.6
  • 17
    • 0019644298 scopus 로고
    • The ageing process: Major risk factor for disease and death
    • [Medline] [CrossRef]
    • H arman, D. 1981. The ageing process: major risk factor for disease and death. Proc. Natl. Acad. Sci. USA 78: 7124- 7128 [Medline] [CrossRef]
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 7124-7128
    • Harman, D.1
  • 18
    • 68849096206 scopus 로고    scopus 로고
    • Crocus sativus L. (Saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle
    • [Medline] [CrossRef]
    • H osseinzadeh, H., Modaghegh, M.H., and Saffari, Z. 2009. Crocus sativus L. (Saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evid. Based Complement. Alternat. Med. 6: 343-350. [Medline] [CrossRef]
    • (2009) Evid. Based Complement. Alternat. Med , vol.6 , pp. 343-350
    • Hosseinzadeh, H.1    Modaghegh, M.H.2    Saffari, Z.3
  • 19
    • 27444442382 scopus 로고    scopus 로고
    • Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus
    • [Medline]
    • H osseinzadeh, H. and Sadeghnia, H.R. 2005. Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. J. Pharm. Pharm. Sci. 8: 394-399. [Medline]
    • (2005) J. Pharm. Pharm. Sci , vol.8 , pp. 394-399
    • Hosseinzadeh, H.1    Sadeghnia, H.R.2
  • 20
    • 2942555103 scopus 로고    scopus 로고
    • Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans
    • [Medline] [CrossRef]
    • Keaney, M., Matthijssens, F., Sharpe, M., Vanfleteren, J., and Gems, D. 2004. Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans. Free Radic. Biol. Med. 37: 239-250. [Medline] [CrossRef]
    • (2004) Free Radic. Biol. Med , vol.37 , pp. 239-250
    • Keaney, M.1    Matthijssens, F.2    Sharpe, M.3    Vanfleteren, J.4    Gems, D.5
  • 21
    • 69249164798 scopus 로고    scopus 로고
    • Effects of saffron and its active constituents, crocin and safranal, on prevention of indomethacin induced gastric ulcers in diabetic and nondiabetic rats
    • Kianbakht, S. and Mozaffari, K. 2009. Effects of saffron and its active constituents, crocin and safranal, on prevention of indomethacin induced gastric ulcers in diabetic and nondiabetic rats. J. Med. Plants 8: 30-38.
    • (2009) J. Med. Plants , vol.8 , pp. 30-38
    • Kianbakht, S.1    Mozaffari, K.2
  • 22
    • 84878633136 scopus 로고    scopus 로고
    • Saffron administration prevents selenite-induced cataractogenesis
    • [Medline]
    • M akri, O.E., Ferlemi, A.V., Lamari, F.N., and Georgakopoulos, C.D. 2013. Saffron administration prevents selenite-induced cataractogenesis. Mol. Vis. 19: 1188-1197. [Medline]
    • (2013) Mol. Vis , vol.19 , pp. 1188-1197
    • Makri, O.E.1    Ferlemi, A.V.2    Lamari, F.N.3    Georgakopoulos, C.D.4
  • 23
    • 0016272750 scopus 로고
    • Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase
    • [Medline] [CrossRef]
    • M arklund, S. and Marklund, G. 1974. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47: 469-474. [Medline] [CrossRef]
    • (1974) Eur. J. Biochem , vol.47 , pp. 469-474
    • Marklund, S.1    Marklund, G.2
  • 25
    • 2342429093 scopus 로고    scopus 로고
    • Oxidative stress in mild cognitive impairment and Alzheimer disease: A continuum
    • [Medline]
    • M ecocci, P. 2004. Oxidative stress in mild cognitive impairment and Alzheimer disease: a continuum. J. Alzheimers Dis. 6: 159-163. [Medline]
    • (2004) J. Alzheimers Dis , vol.6 , pp. 159-163
    • Mecocci, P.1
  • 26
    • 0033765735 scopus 로고    scopus 로고
    • Oxidative injury in diseases of the central nervous system: Focus on Alzheimer's disease
    • [Medline] [CrossRef]
    • Praticò, D. and Delanty, N. 2000. Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease. Am. J. Med. 109: 577-585. [Medline] [CrossRef]
    • (2000) Am. J. Med , vol.109 , pp. 577-585
    • Praticò, D.1    Delanty, N.2
  • 27
    • 0036284936 scopus 로고    scopus 로고
    • Increase of brain oxidative stress in mild cognitive impairment: A possible predictor of Alzheimer disease
    • [Medline] [CrossRef]
    • Praticò, D., Clark, C.M., Liun, F., Rokach, J., Lee, V.Y., and Trojanowski, J.Q. 2002. Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch. Neurol. 59: 972-976. [Medline] [CrossRef]
    • (2002) Arch. Neurol , vol.59 , pp. 972-976
    • Praticò, D.1    Clark, C.M.2    Liun, F.3    Rokach, J.4    Lee, V.Y.5    Trojanowski, J.Q.6
  • 28
    • 0026737356 scopus 로고
    • The role of glutathione in aging and cancer
    • [Medline] [CrossRef]
    • R ichie, J.P. Jr. 1992. The role of glutathione in aging and cancer. Exp. Gerontol. 27: 615-626. [Medline] [CrossRef]
    • (1992) Exp. Gerontol , vol.27 , pp. 615-626
    • Richie, J.P.1
  • 29
    • 79956348262 scopus 로고    scopus 로고
    • Suppression of pulmonary tumor promotion and induction of apoptosis by Crocus sativus L. extraction
    • [Medline] [CrossRef]
    • Samarghandian, S., Tavakkol Afshari, J., and Davoodi, S. 2011 Suppression of pulmonary tumor promotion and induction of apoptosis by Crocus sativus L. extraction. Appl. Biochem. Biotechnol. 164: 238-247. [Medline] [CrossRef]
    • (2011) Appl. Biochem. Biotechnol , vol.164 , pp. 238-247
    • Samarghandian, S.1    Tavakkol Afshari, J.2    Davoodi, S.3
  • 30
    • 78149457185 scopus 로고    scopus 로고
    • Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line
    • [Medline] [CrossRef]
    • Samarghandian, S., Boskabady, M.H., and Davoodi, S. 2010. Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line. Pharmacogn. Mag. 6: 309-314. [Medline] [CrossRef]
    • (2010) Pharmacogn. Mag , vol.6 , pp. 309-314
    • Samarghandian, S.1    Boskabady, M.H.2    Davoodi, S.3
  • 31
    • 84897993549 scopus 로고    scopus 로고
    • Anticarcinogenic effect of saffron (Crocus sativus L.) and its ingredients
    • [Medline] [CrossRef]
    • Samarghandian, S. and Borji, A. 2014. Anticarcinogenic effect of saffron (Crocus sativus L.) and its ingredients. Pharmacogn. Res. 6: 99-107. [Medline] [CrossRef]
    • (2014) Pharmacogn. Res , vol.6 , pp. 99-107
    • Samarghandian, S.1    Borji, A.2
  • 32
    • 84890146337 scopus 로고    scopus 로고
    • Safranal treatment improves hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats
    • [Medline]
    • Samarghandian, S., Borji, A., Delkhosh, M.B., and Samini, F. 2013. Safranal treatment improves hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. J. Pharm. Pharm. Sci. 16: 352-362. [Medline]
    • (2013) J. Pharm. Pharm. Sci , vol.16 , pp. 352-362
    • Samarghandian, S.1    Borji, A.2    Delkhosh, M.B.3    Samini, F.4
  • 33
    • 84884625812 scopus 로고    scopus 로고
    • DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line
    • [Medline] [CrossRef]
    • Samarghandian, S. and Shabestari, M.M. 2013. DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line. Indian J. Urol. 29: 177-183. [Medline] [CrossRef]
    • (2013) Indian J. Urol , vol.29 , pp. 177-183
    • Samarghandian, S.1    Shabestari, M.M.2
  • 34
    • 84889063132 scopus 로고    scopus 로고
    • Crocus sativus L. (saffron) stigma aqueous extract induces apoptosis in alveolar human lung cancer cells through caspase-dependent pathways activation
    • [Medline] [CrossRef]
    • Samarghandian, S., Borji, A., Farahmand, S.K., Afshari, R., and Davoodi, S. 2013. Crocus sativus L. (saffron) stigma aqueous extract induces apoptosis in alveolar human lung cancer cells through caspase-dependent pathways activation. Biomed. Res. Int. 2013: 417928. [Medline] [CrossRef]
    • (2013) Biomed. Res. Int , vol.2013 , pp. 417928
    • Samarghandian, S.1    Borji, A.2    Farahmand, S.K.3    Afshari, R.4    Davoodi, S.5
  • 35
    • 0023550043 scopus 로고
    • Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat
    • [Medline] [CrossRef]
    • Sawada, M. and Carlson, J.C. 1987. Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat. Mech. Ageing Dev. 41: 125-137. [Medline] [CrossRef]
    • (1987) Mech. Ageing Dev , vol.41 , pp. 125-137
    • Sawada, M.1    Carlson, J.C.2
  • 36
    • 25844496961 scopus 로고    scopus 로고
    • Amelioration of altered antioxidant status and membrane linked functions by vanadium and Trigonella in alloxan diabetic rat brains
    • [Medline] [CrossRef]
    • Siddiqui, M.R., Taha, A., Moorthy, K., Hussain, M.E., Basir, S.F., and Baquer, N.Z. 2005. Amelioration of altered antioxidant status and membrane linked functions by vanadium and Trigonella in alloxan diabetic rat brains. J. Biosci. 30: 483-490. [Medline] [CrossRef]
    • (2005) J. Biosci , vol.30 , pp. 483-490
    • Siddiqui, M.R.1    Taha, A.2    Moorthy, K.3    Hussain, M.E.4    Basir, S.F.5    Baquer, N.Z.6
  • 37
    • 0037040250 scopus 로고    scopus 로고
    • Membrane association of glutathione S-transferase mGSTA4-4, an enzyme that metabolizes lipid peroxidation products
    • [Medline] [CrossRef]
    • Singh, S.P., Janecki, A.J., Srivastava, S.K., Awasthi, S., Awasthi, Y.C., Xia, S.J., and Zimniak, P. 2002. Membrane association of glutathione S-transferase mGSTA4-4, an enzyme that metabolizes lipid peroxidation products. J. Biol. Chem. 277: 4232-4239. [Medline] [CrossRef]
    • (2002) J. Biol. Chem , vol.277 , pp. 4232-4239
    • Singh, S.P.1    Janecki, A.J.2    Srivastava, S.K.3    Awasthi, S.4    Awasthi, Y.C.5    Xia, S.J.6    Zimniak, P.7
  • 40
    • 77953535803 scopus 로고    scopus 로고
    • Therapeutic potential of Ganoderma lucidum (Fr.) P. Karst. against the declined antioxidant status in the mitochondria of post-mitotic tissues of aged mice
    • [Medline] [CrossRef]
    • Sudheesh, N.P., Ajith, T.A., Ramnath, V., and Janardhanan, K.K. 2010. Therapeutic potential of Ganoderma lucidum (Fr.) P. Karst. against the declined antioxidant status in the mitochondria of post-mitotic tissues of aged mice. Clin. Nutr. 29: 406-412. [Medline] [CrossRef]
    • (2010) Clin. Nutr , vol.29 , pp. 406-412
    • Sudheesh, N.P.1    Ajith, T.A.2    Ramnath, V.3    Janardhanan, K.K.4
  • 41
    • 0345596416 scopus 로고    scopus 로고
    • Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging
    • [Medline] [CrossRef]
    • Tian, L., Cai, Q., and Wei, H. 1998. Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging. Free Radic. Biol. Med. 24: 1477-1484. [Medline] [CrossRef]
    • (1998) Free Radic. Biol. Med , vol.24 , pp. 1477-1484
    • Tian, L.1    Cai, Q.2    Wei, H.3
  • 43
    • 0032869168 scopus 로고    scopus 로고
    • An update on the role of free radicals and antioxidant defense in human disease
    • [Medline] [CrossRef]
    • Vendemiale, G., Grattagliano, I., and Altomare, E. 1999. An update on the role of free radicals and antioxidant defense in human disease. Int. J. Clin. Lab. Res. 29: 49-55. [Medline] [CrossRef]
    • (1999) Int. J. Clin. Lab. Res , vol.29 , pp. 49-55
    • Vendemiale, G.1    Grattagliano, I.2    Altomare, E.3


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