Safranal treatment improves hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 16, Issue 2, 2013, Pages 352-362

  Samarghandian, Saeed ^a   Borji, Abasalt ^a   Delkhosh, Mohammad Bagher ^a   Samini, Fariborz ^b  

^a NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CATALASE; CHOLESTEROL; GLUCOSE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; NITRIC OXIDE; SAFRANAL; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERLIPIDEMIA; LIPID PEROXIDATION; LOW DRUG DOSE; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; BLOOD PROTEINS; CATALASE; CYCLOHEXENES; DIABETES MELLITUS, EXPERIMENTAL; GLUTATHIONE; HYPERGLYCEMIA; HYPERLIPIDEMIAS; HYPOGLYCEMIC AGENTS; LIPIDS; MALE; NITRIC OXIDE; OXIDATIVE STRESS; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; TERPENES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84890146337     PISSN: None     EISSN: 14821826     Source Type: Journal    
DOI: 10.18433/j3zs3q     Document Type: Article

References (51)

1. Chaiyasut C, Kusirisin W, Lailerd N, Lerttrakarnnon P, Suttajit M, Srichairatanakool S. Effects of phenolic compounds of fermented thai indigenous plants on oxidative stress in streptozotocin-induced diabetic rats. J Evid Based Complementary Altern Med, 2011; 3: 1-10.
2. Abou-Seif MA, Youssef AA. Evaluation of some biochemical changes in diabetic patients. Clin Chim Acta, 2004; 346: 161-170.
3. Strain JJ. Disturbances of micronutrient and antioxidant status in diabetes. P Nutr Soc, 1991; 50: 591-604.
4. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes, 1991; 40: 405-412.
5. Mclennan SVS. Heffernen L. Changes in hepatic glutathione metabolism in diabetes. Diabetes, 1991; 40: 344-348.
6. Mullarkey CJD. Edelstein L. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. Biochem Biophys Res Comm, 1990; 173: 932-939.
7. Soto CR., Recoba H, Barron C, Alvarez L. Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas. Comp Biochem Physiol, 2003; 136: 205-212.
8. Young IS, Torney ER. The effect of ascorbate supplementation on 7-oxidative stress in the streptozotocin diabetic rat. Free Radical Biol Med, 2003; 136: 205-212.
9. Abdullaev FJ. Biological effects of saffron. Biofactors, 1993; 4: 83-86.
10. Samarghandian S, Boskabady MH, Davoodi S. Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human 6 lung cancer cell line. Pharmacogn Mag, 2010; 6: 309-314.
11. Samarghandian S, Tavakkol Afshari J, Davoodi S. Suppression of pulmonary tumor Promotion and induction of apoptosis by Crocus sativus L. Extraction. Appl Biochem Biotechnol, 2011; 164: 238-47.
12. Farahmand SK, Samini F, Samini M, Samarghandian S. Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver. Biogerontology, 2013; 14:63-71.
13. Abdullaev FI. Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Det Preven, 2004; 28: 426-432.
14. Abdullaev FI. Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.). Toxicol in vitro, 2003; 17: 751-758.
15. Assimopoulou AN, Sinakos Z, Papageorgiou VP. Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytother Res, 2005; 19: 997-999.
16. Kianbakht S, Hajiaghaee R. Anti-hyperglycemic effects of saffron and its active constituents, crocin and safranal, in alloxan-induced diabetic rats. J Med Plants, 2011; 10: 39-43.
17. Bathaie SZ, Mousavi Z. New applications and mechanisms of action of saffron and its important ingredients. Crit Rev Food Sci Nutr, 2010; 50: 761-786.
18. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys, 1959; 82: 70-77.
19. Genet S, Kale RK, Baquer NZ. Alterations in antioxidantenzymes and oxidative damage in experimental diabetic rattissues: effect of vanadate and fenugreek (Trigonella foe-num graecum). Mol Cell Biochem, 2002; 236: 7-12.
20. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem, 1979; 47: 469-474.
21. Aebi H. Catalase in vitro. Methods Enzymol, 1984; 105: 121-126.
22. Pieper GM, Jordan M, Dondlinger LA, Adams MB, Roza AM. Peroxidative stress in diabetic blood vessels. Reversal by pancreatic islet transplantation. Diabetes, 1995; 44: 884-889.
23. Hortelano S, Dewez B, Genaro AM, Diaz-Guerra MJ, Bosca L. Nitric oxide is released in regenerating liver after partial hepatectomy. Hepatology, 1995; 21: 776-786.
24. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem, 1976; 72: 248-254.
25. Kianbakht S, Mozaffari K. Effects of saffron and its active constituents, crocin and safranal, on prevention of indomethacin induced gastric ulcers in diabetic and nondiabetic rats. J Med Plants, 2009; 8: 5-8.
26. Rahbani M, Mohajeri D, Rezaie A, Doustar Y, Nazeri M. Attenuation of oxidative stress of hepatic tissue by ethanolic extract of saffron (dried stigmas of Crocus sativus L.) in streptozotocin (STZ)- induced diabetic rats. Afr J Pharm Pharmacol, 2011; 5: 2166-2173.
27. Kamalipour M, Akhondzadeh S. Cardiovascular Effects of Saffron: An Evidence-Based Review J Teh Univ Heart Ctr, 2011; 2: 59-61.
28. Budin S, Othman F, Louis SA., Bakar M, Das S, Mohamed J. The effects of palm oil to cotrienolrich fraction supplementation on biochemical parameters, oxidative stress and the vascular wall of streptozotocin-induced diabetic rats. Clincs, 2009; 64: 235-244.
29. Yazdanparast R, Ardestani A, Jamshidi S. Experimental diabetes treated with Achillea santolina: Effect on pancreatic oxidative parameters. J Ethnopharmacol, 2007; 112: 13-18.
30. Elsner M, Guldbakke B, Tiedge M, Munday R, Lenzen S. Relative importance of transport and alkylation for pancreatic -cell toxicity of streptozotocin. Diabetologia, 2000; 43: 1528-1533.
31. Szkudelski T. The mechanism of alloxan and streptozotocin action in cells of the rat pancreas. Physiol Res, 2001; 50: 537-546.
32. Turk J, Corbett JA, Ramanadham S, Bohrer A, McDaniel ML. Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets. Biochem Biophys Res Commun, 1993; 197: 1458-1464.
33. Kroncke KD, Fehsel K, Sommer A, Rodriguez ML. Kolb- Bachofen, V. Nitric oxide generation during cellular metabolization of the diabetogenic Nmethyl- N-nitroso-urea streptozotozin contributes to islet cell DNA damage. Biol Chem Hoppe Seyler, 1995; 376: 179-185.
34. Chatzigeorgiou A, Halapas A, Kalafatakis K, Kamper E. The use of animal models in the study of diabetes mellitus. In Vivo, 2009; 3: 245-258.
35. Shahady E. Hyperlipidemia in diabetes-etiology, consequences and treatment Adapted from Libby P. Circulation, 1995; 91: 2844-2850.
36. Grune T, Siems WG, Petras T. Identification of metabolic pathways of the lipid peroxidation product 4-hydroxynonenal in in situ perfused rat kidney. J Lipid Res, 1997; 38: 1660-1665.
37. Chalupsky K, Cai H. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. Proc Natl Acad Sci USA, 2005; 102: 9056-9061.
38. Guzik TJ, Mussa S, Gastaldi D. Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD (P) H oxidase and endothelial nitric oxide synthase. Circulation, 2002; 105: 1656-1662.
39. Bardell AL, MacLeod KM. Evidence for inducible nitric-oxide synthase expression and activity in vascular smooth muscle of streptozotocin-diabetic rats. J Pharmacol Exp Ther, 2001; 296: 252-259.
40. Soto CP, Perez BL, Favari LP, Reyes JL. Prevention of alloxan-induced diabetes mellitus in the rat by silymarin. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol, 1998; 119: 125-129.
41. El-Missiry MA. Enhanced testicular antioxidant system by ascorbic acid in alloxan diabetic rats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol, 1999; 124: 233-237.
42. Nishikimi M, Rao NA, Yagl K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulphate and molecular oxygen. Biochem Biophys Res Commun, 1972; 46: 844-853.
43. Arasteh A, Aliyev A, Khamnei S, Delazar A, Mesgari M, Mehmannavaz Y. Effects of hydromethanolic extract of saffron (Crocus sativus) on serum glucose, insulin and cholesterol levels in healthy male rats. J Med Plants Res, 2010; 4: 397-402.
44. Xiang M, Yang M, Zhou C, Liu J, Li W, Qian Z. Crocetin prevents AGEs-induced vascular endothelial cell apoptosis. Pharmacol Res, 2006; 54: 268-274.
45. Johansen JS, Harris AK, Rychly DJ, Ergul A.Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol, 2005; 4:5.
46. Wiernsperger NF. Oxidative stress as a therapeutic target in diabetes: revisiting the controversy. Diabetes Metab, 2003; 29: 579-85.
47. Assimopoulou AN, Sinakos Z, Papageorgiou VP. Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytother Res, 2005; 19: 997-1000.
48. Bharti S, Golechha M, Kumari S, Siddiqui KM, Arya DS. Akt/GSK-3b/eNOS phosphorylation arbitrates safranal- induced myocardial protection against ischemia-reperfusion injury in rats. Eur J Nutr, 2012; 51: 719-727.
49. Halataei BA, Khosravi M, Arbabian S, Sahraei H, Golmanesh L, Zardooz H, Jalili C, Ghoshooni H. Saffron (Crocus sativus) aqueous extract and its constituent crocin reduces stress-induced anorexia in mice. Phytother Res, 2011; 25: 1833-1838.
50. Hosseinzadeh H, Sadeghnia HR. Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. J Pharm Pharm Sci, 2005; 8:394-399.
51. Papandreou MA, Tsachaki M, Efthimiopoulos S, Cordopatis P, Lamari FN, Margarity M. Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection. Behav Brain Res, 2011; 219: 197-20.