An update on the role of free radicals and antioxidant defense in human disease

International Journal of Clinical and Laboratory Research

Volumn 29, Issue 2, 1999, Pages 49-55

  Vendemiale, G ^a   Grattagliano, I ^a   Altomare, E ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Antioxidants; Free radicals; Glutathione; Oxidative stress; Oxidized proteins; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; FREE RADICAL; GLUTATHIONE; REACTIVE OXYGEN METABOLITE;

AGING; ALCOHOLISM; ARTERIOSCLEROSIS; DIABETES MELLITUS; FATTY LIVER; GENERAL ASPECTS OF DISEASE; HUMAN; ISCHEMIA; LIPID PEROXIDATION; METABOLISM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; REPERFUSION INJURY; REVIEW;

AGING; ALCOHOLISM; ANTIOXIDANTS; ARTERIOSCLEROSIS; DIABETES MELLITUS; DISEASE; FATTY LIVER; FREE RADICALS; GLUTATHIONE; HUMANS; ISCHEMIA; LIPID PEROXIDATION; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; VITAMIN E;

EID: 0032869168     PISSN: 09405437     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005990050063     Document Type: Review

References (85)

1. 3 antigens. Proc Natl Acad Sci USA 1990; 87:9943.
2. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organ. Physiol Rev 1979; 59:527.
3. Altomare E, Grattagliano I, Vendemiale G, Palmieri V, Palasciano G. Acute ethanol administration induces oxidative modifications in rat pancreatic tissue. Gut 1996; 38:742.
4. Grattagliano I, Vendemiale G, Errico F, Bolognino A, Lilo F, Salerno MT, Altomare E. Chronic ethanol intake induces oxidative alterations in rat testis. J Appl Toxicol 1997: 17:307.
5. Guerrieri F, Vendemiale G, Grattagliano I, Cocco T, Pellecchia G, Altomare E. Mitochondrial oxidative alterations following partial hepatectomy. Free Radic Biol Med 1999; 26:34.
6. Fink R, Marjot DH, Cawood P. Increased free-radical activity in alcoholics. Lancet 1985; 11:291.
7. Altomare E, Vendemiale G, Albano O. Hepatic glutathione content in patients with alcoholic and non-alcoholic liver disease. Life Sci 1988; 43:991.
8. Gut A, Shiel N, Kay PM. Segal I, Braganza JM. Heightened free radical activity in blacks with chronic pancreatitis at Johannesburg, South Africa. Clin Chim Acta 1994; 230:189.
9. De Capoa A, Ferraro M, Lavia P, Pelliccia F, Finazzi-Agro A. Silver staining of the nucleolus organizer regions (NOR) requires clusters of sulfhydryl groups. J Histochem Cytochem 1982; 30:908.
10. Pascale R, Pirisi L, Daino L, Zanetti S, Satta A, Bartoli E, Feo F. Role of phosphatidylethanolamine methylation in the synthesis of phosphatidylcholine by hepatocytes isolated from choline-deficient rats. FEBS Lett 1982; 145:293.
11. Vendemiale G, Guerrieri F, Grattagliano I, Didonna D, Muolo L, Altomare E. Mitochondrial oxidative phosphorylation and intracellular glutathione compartmentation during rat liver regeneration. Hepatology 1995; 21:1450.
12. Shaw S, Jayatilleke E, Lieber CS. Lipid peroxidation as a mechanism of alcoholic liver injury: role of iron mobilization and microsomal induction. Alcohol 1988; 5:135.
13. Britton RS, O'Neill R, Bacon BR. Hepatic mitochondrial malondialdehyde metabolism in rats with chronic iron overload. Hepatology 1990; 11:93.
14. Sokol RJ, Twedt D, McKim JM, Devereaux MW, Karrer FM, Kam I, Steigman G von, Narkewicz MR, Bacon BR, Britton RS, Neuschwander-Tetri BA. Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis. Gastroenterology 1994; 107:1788.
15. Sokol RJ, Devereaux M, Mierau GW, Hambige KM, Shikes RH. Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload. Modification by vitamin E deficiency. Gastroenterology 1990; 99:1061.
16. Esterbauer H, Schaur KG, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radic Biol Med 1991; 11:81.
17. Fairhurst S, Barber DJ, Clark B, Horton AA. Studies on paracetamol-induced lipid peroxidation. Toxicology 1982; 23:249.
18. Shaw S, Jayatilleke E, Ross WA, Gordon ER, Lieber CS. Ethanol-induced lipid peroxidation: potentiation by long-term alcohol feeding and attenuation by methionine. J Lab Clin Med 1981: 98:417.
19. Fujii S, Dale GL, Beutler E. GSH-dependent protection against oxidative damage of the human red cell membrane. Blood 1984; 63:1096.
20. Grattagliano I, Vendemiale G, Sabbà C, Buonamico P, Altomare E. Oxidation of circulating proteins in alcoholics: role of acetaldehyde and xanthine oxidase. J Hepatol 1996; 25:28.
21. Casini A, Ceni E, Salzano R, Biondi P, Parola M, Galli A, Foschi M, Caligiuri A, Pinzani M, Surrenti C. Neutrophil-derived Superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: role of nitric oxide. Hepatology 1997; 25:361.
22. Pinzani M, Marra F, Carloni V, Signal transduction in hepatic stellate cells. Liver 1998; 18:2.
23. Oliver CN, Ahn BW, Moerman EJ, Goldstein S, Stadtman ER. Age-related changes in oxidized proteins. J Biol Chem 1987; 262:5488.
24. Augusteyn RC. Protein modification in cataract: possible mechanisms. In: Duncan G. ed. Mechanisms of cataract formation in the human lens. New York: Academic Press; 1981;71-115.
25. Guerrieri F, Vendemiale G, Turturro N, Fratello A, Furio A, Muolo L, Grattagliano I, Papa S. Alteration of mitochondrial F0F1 ATP synthase during aging. Possible involvement of oxygen free radicals. Ann N Y Acad Sci 1996; 786:62.
26. Ajiboye R, Harding JJ. The non enzymatic glycosylation of bovine lens proteins by glucosamine and its inhibition by aspirin, ibuprofen and glutathione. Exp Eye Res 1989; 49:31.
27. Shigenaga HK, Hagen TM, Ames HN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci USA 1994; 91:10771.
28. Wieland P, Lauterburg BH, Oxidation of mitochondrial proteins and DNA following administration of ethanol. Biochem Biophys Res Commun 1995; 213:815.
29. Rengstrom J, Nilsson J, Tornvall P, Landou C, Hamsten A. Susceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 1992; 339:1183.
30. Steinbrecher UP, Parathasarathy S, Leake DS, Witztum JL, Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci USA 1984; 81:3883.
31. Berliner JA, Territo MC, Sevanian A, Ramin S, Kim JA, Bamshad B, Esterson M, Fogelman AM. Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J Clin Invest 1990; 85:1260.
32. Wanatabe J, Umeda F, Wakasugi H, Ibayashi H. Effect of vitamin E on platelet aggregation in diabetes mellitus. Thromb Haemost 1984; 51:313.
33. Jessup W, Rankin SM, De Whalley CV, Hoult JRS, Scott J, Leake DS. Alpha-tocopherol consumption during low-density lipoprotein oxidation. Biochem J 1990; 265:399.
34. Carney JM, Starke-Reed PE, Oliver CN, Landum RW, Cheng MS, Wu JF, Floyd RA. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-α-phenylnitrone. Proc Natl Acad Sci USA 1991;88:3633.
35. Wiztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest 1991; 88:1785.
36. De La Asuncion JG, Millan A, Pla R, Bruseghini L, Esteras A, Pallardo FV, Sastre J, Vina J. Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA FASEB J 1996; 10:333.
37. Gey F, Puska P, Jordan P, Moser UK. Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Am J Clin Nutr 1991: 53;326S.
38. Altomare E, Vendemiale G, Procacci V, Chicco D, Cirelli F. Increased lipid peroxidation in type-2 poorly controlled diabetic patients. Diabetes Metab 1992; 18:264.
39. Altomare E, Vendemiale G, Grattaghano I, Angelini P, Micelli-Ferrari T, Cardia L. Human diabetic cataract: role of lipid peroxidation. Diabetes Metab 1995; 21:173.
40. Maxwell SRJ, Thomason H, Sandler D, Legneu C, Baxter MA, Thorpe GHG, Jones AF, Barnett AH. Antioxidant status in patients with uncomplicated insulin-dependent and non-insulin dependent diabetes mellitus. Eur J Clin Invest 1997; 27:484.
41. Lyon TJ, Li W, Wells-Knecht MC, Jokl R. Toxicity of mildly modified low density lipoproteins to cultured retinal capillary endothelial cells and pericytes. Diabetes 1994; 43:1090.
42. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991; 40:405.
43. Cheng M, Gonzales G. The effect of high glucose and oxidative stress on lens metabolism, aldose reductase and senile cataractogenesis. Metabolism 1986; 35:10.
44. Ceriello A, Pirisi M. Is oxidative stress the missing link between insulin resistance and atherosclerosis? Diabetologia 1996; 39:357.
45. Altomare E, Grattagliano I, Vendemiale G, Micelli-Ferrari, Signorile A, Cardia L. Oxidative protein damage in human diabetic eye: evidence for a retinal participation. Eur J Clin Invest 1997; 27:141.
46. Williamson JR, Chang K, Frangos M. Hasan KS, Ido Y, Kawamura T, Nyengaard JR, Van Den Enden M, Kilo C, Tilton RG. Hyperglycaemic pseudohypoxia and diabetic complications. Diabetes 1993; 42:801.
47. Vendemiale G, Grattagliano I, Micelli-Ferrari T, Cardia L, Altomare E. Abnormal redox status in the lens and vitreous of diabetic subjects. Diabetologia 1996; 39:1239.
48. Babizhaev MA, Deev AJ. Lens opacity induced by lipid peroxidation products as a model of cataract associated with retinal disease. Biochem Biophys Acta 1989; 1004:124.
49. Grattagliano I, Vendemiale G, Boscia F, Micelli-Ferrari T, Cardia L, Altomare E, Oxidative retinal products and ocular damages in diabetic patients. Free Radic Biol Med 1998; 25:369.
50. Micelli-Ferrari T, Vendemiale G, Grattagliano I, Boscia F, Arnese L, Altomare E, Cardia L. Role of lipid peroxidation in the pathogenesis of myopic and senile cataract. Br J Ophthalmol 1996; 80:840.
51. Rao NA, Sevanian A, Fernandez MAS, Romero JL, Faure JP, Kozak Y de, Till GO, Marak GE. Role of oxygen radicals in experimental allergic uveitis. Invest Ophthalmol Vis Sci 1987; 28:886.
52. Martensson J, Steinherz R, Jain A, Meister A. GSH ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage. Proc Natl Acad Sci USA 1989; 86:8728.
53. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985; 312:159.
54. Kobayashi H, Nonami T, Kurokawa T, Marada A, Nakao A, Sugiyama S, Ozawa T, Takagi H. Changes in the glutathione redox system during ischemia and reperfusion in rat liver. Scand J Gastroenterol 1992; 27:711.
55. Samarasinghe DA, Farrell GC. The central role of sinusoidal endothelial cells in hepatic hypoxia-reoxygenation injury in the rat. Hepatology 1996; 24:1230.
56. Kuzume M, Nakano H, Yamaguchi M, Matsurniya A, Shimokohbe G, Kitamura N, Nagasaki H, Kumada K. A monoclonal antibody against ICAM-1 suppresses hepatic ischemia-reperfusion injury in rats. Eur Surg Res 1997; 27:93.
57. Jaeschke H, Bautista AP, Spolarics Z, Spitzer JJ. Superoxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia. Free Radic Res Commun 1991; 15:277.
58. Jaeschke H, Farood A. Neutrophils and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am J Physiol 1991; 260:G355.
59. Jaeschke H, Smith CV, Mitchell JR. Reactive oxygen species during ischemia-reflow injury in isolated perfused rat liver. J Clin Invest 1988; 81:1240.
60. Bilzer M, Lauterburg BH. Oxidant stress and potentiation of ischemia/reperfusion injury to the perfused rat liver by human polymorphonuclear leukocytes. J Hepatol 1994; 20:473.
61. Shibuya H, Ohkohchi N, Seya K, Satomi S. Kupffer cells generate Superoxide anions and modulate reperfusion injury in rat livers after cold preservation. Hepatology 1997; 25:356.
62. Lieber CS. Alcohol, protein metabolism and liver injury. Gastroenterology 1980; 79:373.
63. Stevens VJ, Fantl WJ, Newman BC. Acetaldehyde adducts with hemoglobin. J Clin Invest 1981; 67:361.
64. Kera Y, Ohbora Y, Komura S. The metabolism of acetaldehyde and not acetaldehyde itself is responsible for in vivo ethanol-induced lipid peroxidation in rats. Biochem Pharmacol 1988; 37:363.
65. Albano E, Tomasi A, Goria-Gatti L, Dianzani MU. Spin trapping of free radical species produced during the microsomal metabolism of ethanol. Chem Biol Interact 1988; 65:223.
66. Vendemiale G, Grattagliano I, Signorile A, Altomare E. Ethanol-induced changes of intracellular thiol compartmentation and protein redox status in the rat liver: effect of tauroursodeoxycholate. J Hepatol 1998; 28:46.
67. Videla LA, Valenzuela A. Alcohol ingestion, liver GSH and lipoperoxidation: metabolic interrelations and pathological implications. Life Sci 1982; 31:2395.
68. Lauterburg BH, Bilzer M. Mechanisms of acetaldehyde hepatotoxicity. Hepatol 1988; 7:384.
69. Uchida T, Kronborg I, Peters RL. Giant mitochondria in the alcoholic liver diseases. Their identification, frequency and pathologic significance. Liver 1984; 4:29.
70. Mufti SI, Eskelson CD, Odeleye OE, Nachiappan V. Alcoholassociated generation of oxygen free radicals and tumor promotion. Alcohol Alcohol 1993; 28:621.
71. Altomare E, Grattagliano I, Didonna D, Gentile A, Vendemiale G. Gastric and intestinal ethanol toxicity in the rat. Effect on glutathione level and the role of alcohol and acetaldehyde metabolisms. Ital J Gastroenterol Hepatol 1998; 90:86.
72. Bora PS, Bora NS, Wu XL, Lange LG. Molecular cloning, sequencing, and expression of human myocardial fatty acid ethyl ester synthase-III cDNA. J Biol Chem 1991; 26:16774.
73. Clot P, Tabone M, Aricò S, Albano E. Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake. Gut 1994; 35:1637.
74. Bellentani S, Tiribelli C, Saccoccio G, Sodde M, Fratti N, De Martin C, Cristianini G and the Dionysos Study Group. Prevalence of chronic liver disease in the general population of Northern Italy: the Dionysos Study. Hepatology 1994; 20: 1442.
75. Strasberg SM, Howard TK, Molmenti EP, Hertl M. Selecting the donor liver: risk factors for poor function after orthotopic liver transplantation. Hepatology 1994; 20:829.
76. Caraceni P, Grattagliano I, Domenicali M, Nardo B, Dall'Agata M, Simoncini M, Vendemiale G, Altomare E, Cavallari A, Trevisani F, Bernardi M. Effect of fasting on mitochondrial injury in a rat model of fatty liver (abstract). Hepatology 1998; 28:324A
77. Lauterburg BH, Velez MA. GSH deficiency in alcoholics: risk factor for paracetamol hepatotoxicity. Gut 1988; 29:1153.
78. Grattagliano I, Wieland P, Schranz C, Lauterburg BH. Effect of oral GSH monoethyl ester and GSH on circulating and hepatic sulfhydryls in the rat. Pharmacol Toxicol 1994; 75:343.
79. Lieber CS Casini A, DeCarli LM, Kim CL, Lowe K, Sasaki R, Leo MA. S-Adenosyl-methionine attenuates alcohol-induced liver injury in the baboon. Hepatology 1990; 11:165.
80. Frezza M, Surrenti C, Mantillo G, Fiaccadori F, Bortolini M, DiPadova C. Oral S-Adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis: a doubleblind, placebo-controlled study. Gastroenterology 1990; 99:211.
81. Prescott LF, Ballantyne A, Park J, Adriaenssens P, Proudfoot AT. Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet 1977; II:432.
82. Grattagliano I, Wieland P, Schranz C, Lauterburg BH. Disposition of glutathione monoethyl ester in the rat: glutathione ester is a slow release form of extracellular glutathione. J Pharmacol Exp Ther 1995; 272:484.
83. Grattagliano I, Lauterburg BH. Reperfusion injury of the liver: role of mitochondria and protection by glutathione ester. J Surg Res 1999; in press.
84. Neuschwander-Tyetri B, Ferrell LD, Sukhabote RJ, Grendell JH. Glutathione monoethyl ester ameliorates caerulein-induced pancreatitis in the mouse. J Clin Invest 1992; 89:109.
85. Levy EJ, Anderson ME, Meister A. Transport of glutathione diethyl ester into human cells. Proc Natl Acad Sci USA 1993; 90:9171.