Therapeutic potential of Ganoderma lucidum (Fr.) P. Karst. against the declined antioxidant status in the mitochondria of post-mitotic tissues of aged mice

Clinical Nutrition

Volumn 29, Issue 3, 2010, Pages 406-412

  Sudheesh, N P ^a   Ajith, T A ^b   Ramnath, V ^c   Janardhanan, K K ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

^b AMALA INSTITUTE OF MEDICAL SCIENCES   (India)

^c KERALA AGRICULTURAL UNIVERSITY   (India)

Author keywords

Antioxidants; Congestive heart failure; Ganoderma lucidum; Mitochondrial ageing; Neurodegenerative diseases; Reactive oxygen species

Indexed keywords

ADVANCED OXIDATION PROTEIN PRODUCT; ALCOHOL; CATALASE; GANODERMA LUCIDUM EXTRACT; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID; ANTIOXIDANT; PROTEIN; SUPEROXIDE DISMUTASE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN; CELL ISOLATION; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FREEZE DRYING; HEART; LIPID PEROXIDATION; MALE; MITOCHONDRION; MITOSIS; MOUSE; NONHUMAN; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; ETHNOPHARMACOLOGY; GANODERMA LUCIDUM; HEART MITOCHONDRION; INDIA; METABOLISM; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS;

AGING; ANIMALS; ANTIOXIDANTS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHNOPHARMACOLOGY; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; INDIA; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED BALB C; MITOCHONDRIA; MITOCHONDRIA, HEART; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEINS; REACTIVE OXYGEN SPECIES; REISHI; SUPEROXIDE DISMUTASE;

EID: 77953535803     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2009.12.003     Document Type: Article

References (65)

1. Harman D. Ageing: a theory based on free radical and radiation chemistry. J Gerontol 1956, 11:298-300.
2. Harman D. Free radical theory of ageing. Mutat Res 1992, 275:257-266.
3. Kayali R., Cakatay U., Akcay T., Altug T. Effect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat. Cell Biochem Funct 2006, 24:79-85.
4. Coleman R., Silbermann M., Gershon D., Reznick A.Z. Giant mitochondria in the myocardium of ageing and endurance-trained mice. Gerontology 1987, 33:34-39.
5. Muscari C., Giaccari A., Giorano E., Clo C., Guarnieri C., Caldarera C.M. Role of reactive oxygen species in cardiovascular ageing. Mol Cell Biochem 1996, 160-161:159-166.
6. Suh J.H., Shigeno E.T., Morrow J.D., Cox B., Rocha A.E., Frei B., et al. Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid. FASEB J 2001, 15(3):700-706.
7. Lesnefsky E.J., Moghaddas S., Tandler B., Kerner J., Hoppel C.L. Mitochondria dysfunction in cardiac disease: ischemia-reperfusion, aging and heart failure. J Mol Cell Cardiol 2001, 33:1065-1089.
8. Floyd R.A., Hansley K. Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 2002, 23:795-807.
9. Navarro A., Boveris A. Rat brain and liver mitochondria develop oxidative stress and loose enzymatic activity with aging. Am J Physiol Regul Integr Comp Physiol 2004, 287:R1244-R1249.
10. Beal M.F. Mitochondrial dysfunction in neurodegenerative diseases. Biochim Biophys Acta 1998, 1366:201-223.
11. Trushina E., McMurray C.T. Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases. Neuroscience 2007, 145:1223-1248.
12. Kelso G.F., Porteous C.M., Hughes G., Ledgerwood E.C., Gane A.M., Smith R.A., et al. Prevention of mitochondrial oxidative damage using targeted antioxidants. Ann N Y Acad Sci 2002, 959:263-274.
13. Liu J., Atamna H., Kuratsune H., Ames B.N. Delaying brain mitochondrial decay and aging with antioxidants and metabolites. Ann N Y Acad Sci 2002, 959:133-166.
14. Kwok Y., Ng K.F., Li C.C., Lam C.C., Man R.Y. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005, 101:423-426.
15. Tang W., Gao Y., Chen G., Gao H., Dai X., Ye J., et al. A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia. J Med Food 2005, 8:53-58.
16. Chen X., Hu Z.P., Yang X.X., Huang M., Gao Y., Tang W., et al. Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer. Int Immunopharmacol 2006, 6:499-508.
17. Jones S., Janardhanan K.K. Antioxidant and antitumor activity of Ganoderma lucidum (Curt: fr) P. Karst - Reishi (Aphyllophoromycetideae) from South India. Int J Med Mushr 2000, 2:195-200.
18. Lakshmi B., Ajith T.A., Sheena M., Nidhi G., Janardhanan K.K. Antiperoxidative, anti-inflammatory and antimutagenic activities of ethanol extract of the mycelium of Ganoderma lucidum occurring in South India. Teratog Carcinog Mutagen 2003, s1:85-97.
19. Pillai G.T., Nair C.K.K., Janardhanan K.K. Polysaccharides isolated from Ganoderma lucidum occurring in Southern parts of India, protects radiation induced damages both in vitro and in vivo. Environ Toxicol Pharmcol 2008, 26:80-85.
20. Lai C.S., Yu M.S., Yuen W.H., So K.F., Zee S.Y., Chang R.C. Antagonizing β-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum. Brain Res 2008, 1190:215-224.
21. Ajith T.A., Sudheesh N.P., Roshny D., Abishek G., Janardhanan K.K. Effect of Ganoderma lucidum on the activities of mitochondrial dehydrogenases and complex I and II of electron transport chain in the brain of aged rats. Exp Gerontol 2009, 44:219-223.
22. Sudheesh N.P., Ajith T.A., Janardhanan K.K. Ganoderma lucidum (Fr.) P. Karst enhances activities of heart mitochondrial enzymes and respiratory chain complexes in the aged rat. Biogerontology 2009, 10:627-636.
23. McCord J.M., Fridovich I. Superoxide dismutase, an enzymatic function for erythrocuprein. J Biol Chem 1969, 244:6049-6055.
24. Beers R.F., Sizer I.W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 1952, 195:133-140.
25. Hafemann D.G., Sunde R.A., Houestra W.G. Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J Nutr 1974, 104:580-587.
26. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974, 249:7130-7139.
27. Moron M.S., Depierre J.W., Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979, 582:67-78.
28. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-358.
29. Kayali R., Cakatay U., Tekeli F. Male rats exhibit higher oxidative protein damage than females of the same chronological age. Mech Ageing Dev 2007, 128:365-369.
30. Wasilewski M., Wojtczak L. Effects of N-acylethanolamines on the respiratory chain and production of reactive oxygen species in heart mitochondria. FEBS Lett 2005, 579:4724-4728.
31. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
32. Savitha S., Pannerselvam C. Mitochondrial membrane damage during aging process in rat heart: potential efficacy of l-carnitine and dl-α-lipoic acid. Mech Ageing Dev 2006, 127:349-355.
33. Radi R., Turrens J.F., Chang L.Y., Bush K.M., Crapo J.D., Freeman B.A. Detection of catalase in rat heart mitochondria. J Biol Chem 1991, 266:22028-22034.
34. Savitha S., Tamilselvan J., Anusuyadevi M., Pannerselvam C. Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of dl-α-lipoic acid and l-carnitine. Clin Chim Acta 2005, 355:173-180.
35. Salvi M., Battaglia V., Brunati A.M., La Rocca N., Tibaldi E., Pietrangeli P., et al. Catalase takes part in rat liver mitochondria oxidative stress defense. J Biol Chem 2007, 282:24407-24415.
36. Srividhya R., Zarkovic K., Stroser M., Waeg G., Zarkovic N., Kalaiselvi P. Mitochondrial alteration in aging rat brain: effective role of (-)-epigallocatechin gallate. Int J Dev Neurosci 2009, 27:223-231.
37. Jouihan H.A., Cobine P.A., Cooksey R.C., Hoagland E.A., Boudina S., Abel E.D., et al. Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Mol Med 2008, 14:98-108.
38. Sitte N., Merker K., Von Z.T., Davies K.J., Grune T. Protein oxidation and degeneration during cellular senescence of human BJ fibroblast: part II-aging of non-dividing cells. FASEB J 2000, 14:503-510.
39. Shigenaga M.K., Hagen T.M., Ames B.N. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A 1994, 91:10771-10778.
40. Richter C. Oxidative damage to mitochondrial DNA and its relationship to ageing. Int J Biochem Cell Biol 1995, 27:647-653.
41. Dringen R., Gutterer J.M., Hirrlinger J. Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. Eur J Biochem 2000, 267:4912-4916.
42. Townsend D.M., Tew K.D., Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother 2003, 57:145-155.
43. Rikans L.E., Hornbrook K.R. Lipid peroxidation, antioxidant protection and ageing. Biochim Biophys Acta 1997, 1362:116-127.
44. Yu P.B. Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994, 74:134-162.
45. Alderman C.J., Shah S., Foreman J.C., Chain B.M., Katz D.R. The role of advanced oxidation protein products in regulation of dendritic cell function. Free Radic Biol Med 2002, 32:377-385.
46. Cakatay U., Kayali R., Sivas A., Tekeli F. Prooxidant activities of alpha-lipoic acid on oxidative protein damage in the aging rat heart muscle. Arch Gerontol Geriatr 2005, 40:231-240.
47. Cakatay U., Telci A., Kayali R., Tekeli F., Akcay T., Sivas A. Relation of oxidative protein damage and nitrotyrosine levels in the aging rat brain. Exp Gerontol 2001, 36:221-229.
48. Savitha S., Panneerselvam C. Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process. Biogerontology 2006, 7:101-109.
49. Kayali R., Cakatay U., Uzun H., Gene H. Gender difference as regards myocardial protein oxidation in aged rats: male rats have increased oxidative protein damage. Biogerontology 2007, 8:653-661.
50. Hagen T.M., Moreau R., Suh J.H., Visioli F. Mitochondrial decay in the aging rat heart evidence for improvement by dietary supplementation with acetyl-l-carnitine and/or lipoic acid. Ann N Y Acad Sci 2002, 959:491-507.
51. Clausen A., Doctrow S., Baudry M. Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice. Neurobiol Aging 2008, 10.1016/j.neurobiolaging.2008.05.009.
52. Wu J.I., Wu Q.O., Yang X.F., Wei M.K., Zhang J.M., Huang Q., et al. l-Malate reverses oxidative stress and antioxidative defenses in liver and heart of aged rats. Physiol Res 2008, 57:261-268.
53. Cortopassi G.A., Shibata D., Soong N.W., Arnheim N. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci U S A 1992, 89:7370-7374.
54. Cortopassi G.A., Arnheim N. Detection of a specific mitochondria! DNA deletion in tissues of older humans. Nucleic Acids Res 1990, 18:6927-6933.
55. Beyer R.E. An analysis of the role of coenzyme Q in free radical generation and as an anti oxidant. Biochem Cell Biol 1992, 70:390-403.
56. Cadenas E., Davies K.J. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 2000, 29:222-230.
57. Esposito L.A., Melov S., Panov A., Cottrell B.A., Wallace D.C. Mitochondrial disease in mouse results in increased oxidative stress. Proc Natl Acad Sci U S A 1999, 96:4820-4825.
58. Pitkanen S., Robinson B.H. Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase. J Clin Invest 1996, 98:345-351.
59. Halliwell B., Gutteridge J.M.C. Cellular responses to oxidative stress: adaptation, damage, repair, senescence and death. Free radicals in biology and medicine 2007, 268-340. Oxford University Press, Oxford. 4th ed. B. Halliwell, J.M.C. Gutteridge (Eds.).
60. Soong N.W., Hinton D.R., Cortopassi G., Arnheim N. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat Genet 1992, 2:318-323.
61. Corral-Debrinski M., Horton T., Lott M.T., Shoffner J.M., Beal M.F., Wallace D.C. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat Genet 1992, 2:324-329.
62. Sheena N., Ajith T.A., Janardhanan K.K. Anti-inflammatory and antinociceptive activities of Ganoderma lucidum occurring in South India. Pharm Biol 2003, 41:4301-4304.
63. Gao Y.H., Zhou S.F. Cancer prevention and treatment by Ganoderma, a mushroom with medicinal properties. Food Rev Int 2003, 19:275-325.
64. Hui C.W., Di X. Chromatographic and electrophoretic methods for Lingzhi pharmacologically active components. J Chromatogr B 2004, 812:241-257.
65. Chauhan V., Chauhan A. Oxidative stress in Alzheimer's disease. Rev Pathophysiol 2006, 13:195-208.