메뉴 건너뛰기




Volumn 81, Issue , 2015, Pages 53-61

Role of microRNAs in maintaining cancer stem cells

Author keywords

Cancer; Cancer stem cells; Embryonic stem cells (ESCs); EMT; MicroRNAs

Indexed keywords

CELLS; CYTOLOGY; DISEASES; DRUG THERAPY; RNA; TUMORS;

EID: 84922219556     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2014.11.014     Document Type: Review
Times cited : (106)

References (104)
  • 2
    • 0141483064 scopus 로고    scopus 로고
    • Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
    • Passegué E., Jamieson C.H., Ailles L.E., Weissman I.L. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?. Proc. Natl. Acad. Sci. U. S. A. 2003, 100(Suppl. 1):11842-11849.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 11842-11849
    • Passegué, E.1    Jamieson, C.H.2    Ailles, L.E.3    Weissman, I.L.4
  • 3
    • 2942691389 scopus 로고    scopus 로고
    • Stem cell origin of cancer and differentiation therapy
    • Sell S. Stem cell origin of cancer and differentiation therapy. Crit. Rev. Oncol. Hematol. 2004, 51:1-28.
    • (2004) Crit. Rev. Oncol. Hematol. , vol.51 , pp. 1-28
    • Sell, S.1
  • 4
    • 0000886345 scopus 로고
    • Nesso fisio-pathologico tra la struttura dei nei materni e la genesi di alcuni tumori maligni
    • Durante F. Nesso fisio-pathologico tra la struttura dei nei materni e la genesi di alcuni tumori maligni. Arch. Mem. Obs. Chir. Pract. 1874, 11:217-226.
    • (1874) Arch. Mem. Obs. Chir. Pract. , vol.11 , pp. 217-226
    • Durante, F.1
  • 6
    • 34447607512 scopus 로고
    • Congenitales, quergestreiftes Muskelsarkonder Nireren
    • Cohnheim J. Congenitales, quergestreiftes Muskelsarkonder Nireren. Virchows Arch. 1875, 65:64.
    • (1875) Virchows Arch. , vol.65 , pp. 64
    • Cohnheim, J.1
  • 7
    • 0036234659 scopus 로고    scopus 로고
    • Unique molecular and cellular features of acute myelogenous leukemia stem cells
    • Jordan C.T. Unique molecular and cellular features of acute myelogenous leukemia stem cells. Leukemia 2002, 16:559-562.
    • (2002) Leukemia , vol.16 , pp. 559-562
    • Jordan, C.T.1
  • 8
    • 0023922373 scopus 로고
    • Purification and characterization of mouse hematopoietic stem cells
    • Spangrude G.J., Heimfeld S., Weissman I.L. Purification and characterization of mouse hematopoietic stem cells. Science 1988, 241:58-62.
    • (1988) Science , vol.241 , pp. 58-62
    • Spangrude, G.J.1    Heimfeld, S.2    Weissman, I.L.3
  • 10
    • 0036737914 scopus 로고    scopus 로고
    • Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
    • Ignatova T.N., Kukekov V.G., Laywell E.D., Suslov O.N., Vrionis F.D., Steindler D.A. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 2002, 193:193-206.
    • (2002) Glia , vol.193 , pp. 193-206
    • Ignatova, T.N.1    Kukekov, V.G.2    Laywell, E.D.3    Suslov, O.N.4    Vrionis, F.D.5    Steindler, D.A.6
  • 14
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen J., Li Y., Yu T.S., McKay R.M., Burns D.K., Kernie S.G., et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 2012, 488:522-526.
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4    Burns, D.K.5    Kernie, S.G.6
  • 16
    • 1642499415 scopus 로고    scopus 로고
    • Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs
    • Bohnsack M.T., Czaplinski K., Gorlich D. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 2004, 10:185-191.
    • (2004) RNA , vol.10 , pp. 185-191
    • Bohnsack, M.T.1    Czaplinski, K.2    Gorlich, D.3
  • 18
    • 0035189927 scopus 로고    scopus 로고
    • Embryo-derived stem cells: of mice and men
    • Smith A.G. Embryo-derived stem cells: of mice and men. Annu. Rev. Cell Dev. Biol. 2001, 17:435-462.
    • (2001) Annu. Rev. Cell Dev. Biol. , vol.17 , pp. 435-462
    • Smith, A.G.1
  • 19
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75:843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 21
  • 23
    • 25144525014 scopus 로고    scopus 로고
    • Core transcriptional regulatory circuitry in human embryonic stem cells
    • Boyer L.A., Lee T.I., Cole M.F., Johnstone S.E., Levine S.S., Zucker J.P., et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005, 122:947-956.
    • (2005) Cell , vol.122 , pp. 947-956
    • Boyer, L.A.1    Lee, T.I.2    Cole, M.F.3    Johnstone, S.E.4    Levine, S.S.5    Zucker, J.P.6
  • 24
    • 33645381936 scopus 로고    scopus 로고
    • The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
    • Loh Y.H., Wu Q., Chew J.L., Vega V.B., Zhang W., Chen X., G., et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 2006, 38:431-440.
    • (2006) Nat. Genet. , vol.38 , pp. 431-440
    • Loh, Y.H.1    Wu, Q.2    Chew, J.L.3    Vega, V.B.4    Zhang, W.5    Chen, X.G.6
  • 25
    • 33846936234 scopus 로고    scopus 로고
    • Generation and characterization of rabbit embryonic stem cells
    • Wang S., Tang X., Niu Y., Chen H., Li B., Li T., et al. Generation and characterization of rabbit embryonic stem cells. Stem Cells 2007, 25:481-489.
    • (2007) Stem Cells , vol.25 , pp. 481-489
    • Wang, S.1    Tang, X.2    Niu, Y.3    Chen, H.4    Li, B.5    Li, T.6
  • 26
    • 40949130398 scopus 로고    scopus 로고
    • MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells
    • Sinkkonen L., Hugenschmidt T., Berninger P., Gaidatzis D., Mohn F., Artus-Revel C.G., et al. MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells. Nat. Struct. Mol. Biol. 2008, 15:259-267.
    • (2008) Nat. Struct. Mol. Biol. , vol.15 , pp. 259-267
    • Sinkkonen, L.1    Hugenschmidt, T.2    Berninger, P.3    Gaidatzis, D.4    Mohn, F.5    Artus-Revel, C.G.6
  • 27
  • 28
    • 76249119007 scopus 로고    scopus 로고
    • Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
    • Melton C., Judson R.L., Blelloch R. Opposing microRNA families regulate self-renewal in mouse embryonic stem cells. Nature 2010, 463:621-626.
    • (2010) Nature , vol.463 , pp. 621-626
    • Melton, C.1    Judson, R.L.2    Blelloch, R.3
  • 29
    • 80455149978 scopus 로고    scopus 로고
    • MiR-34 miRNAs provide a barrier for somatic cell reprogramming
    • Choi Y.J., Lin C.P., Ho J.J., He X., Okada N., et al. miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat. Cell Biol. 2011, 13:1353-1360.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 1353-1360
    • Choi, Y.J.1    Lin, C.P.2    Ho, J.J.3    He, X.4    Okada, N.5
  • 31
    • 84868356989 scopus 로고    scopus 로고
    • The role and clinical implications of microRNAs in hepatocellular carcinoma
    • Zhao X., Yang Z., Li G., Li D., Zhao Y., Wu Y., et al. The role and clinical implications of microRNAs in hepatocellular carcinoma. Sci. China Life Sci. 2012, 55:906-919.
    • (2012) Sci. China Life Sci. , vol.55 , pp. 906-919
    • Zhao, X.1    Yang, Z.2    Li, G.3    Li, D.4    Zhao, Y.5    Wu, Y.6
  • 32
    • 77955362243 scopus 로고    scopus 로고
    • Hedgehog controls neural stem cells through p53-independent regulation of Nanog
    • Po A., Ferretti E., Miele E., De Smaele E., Paganelli A., Canettieri G. Hedgehog controls neural stem cells through p53-independent regulation of Nanog. EMBO J. 2010, 29:2646-2658.
    • (2010) EMBO J. , vol.29 , pp. 2646-2658
    • Po, A.1    Ferretti, E.2    Miele, E.3    De Smaele, E.4    Paganelli, A.5    Canettieri, G.6
  • 33
    • 84867018979 scopus 로고    scopus 로고
    • Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal
    • Rodova M., Fu J., Watkins D.N., Srivastava R.K., Shankar S. Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal. PLoS One 2012, 7:e46083.
    • (2012) PLoS One , vol.7 , pp. e46083
    • Rodova, M.1    Fu, J.2    Watkins, D.N.3    Srivastava, R.K.4    Shankar, S.5
  • 34
    • 84884623144 scopus 로고    scopus 로고
    • Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma
    • Cheng Y., Cheung A.K., Ko J.M., Phoon Y.P., Chiu P.M., Lo P.H. Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma. BMC Cell Biol. 2013, 14:44.
    • (2013) BMC Cell Biol. , vol.14 , pp. 44
    • Cheng, Y.1    Cheung, A.K.2    Ko, J.M.3    Phoon, Y.P.4    Chiu, P.M.5    Lo, P.H.6
  • 36
    • 68949170622 scopus 로고    scopus 로고
    • Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
    • Ji J., Yamashita T., Budhu A., Forgues M., Jia H.L., Li C., et al. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 2009, 50:472-480.
    • (2009) Hepatology , vol.50 , pp. 472-480
    • Ji, J.1    Yamashita, T.2    Budhu, A.3    Forgues, M.4    Jia, H.L.5    Li, C.6
  • 38
    • 33847686753 scopus 로고    scopus 로고
    • CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity
    • Yin S., Li J., Hu C., Chen X., Yao M., Yan M., et al. CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int. J. Cancer 2007, 120:1444-1450.
    • (2007) Int. J. Cancer , vol.120 , pp. 1444-1450
    • Yin, S.1    Li, J.2    Hu, C.3    Chen, X.4    Yao, M.5    Yan, M.6
  • 39
    • 84863124163 scopus 로고    scopus 로고
    • MicroRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb
    • Zhang J., Luo N., Luo Y., Peng Z., T., Li S. microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb. Int. J. Oncol. 2012, 40:747-756.
    • (2012) Int. J. Oncol. , vol.40 , pp. 747-756
    • Zhang, J.1    Luo, N.2    Luo, Y.3    Peng, Z.T.4    Li, S.5
  • 41
    • 84860141964 scopus 로고    scopus 로고
    • Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellular carcinoma: a retrospective cohort study
    • Liu A.M., Yao T.J., Wang W., Wong K.F., Lee N.P., Fan S.T., et al. Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellular carcinoma: a retrospective cohort study. BMJ Open 2012, 2:e000825.
    • (2012) BMJ Open , vol.2 , pp. e000825
    • Liu, A.M.1    Yao, T.J.2    Wang, W.3    Wong, K.F.4    Lee, N.P.5    Fan, S.T.6
  • 42
    • 84860752172 scopus 로고    scopus 로고
    • Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145
    • Jia Y., Liu H., Zhuang Q., Xu S., Yang Z., Li J., et al. Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145. Oncol. Rep. 2012, 27:1865-1872.
    • (2012) Oncol. Rep. , vol.27 , pp. 1865-1872
    • Jia, Y.1    Liu, H.2    Zhuang, Q.3    Xu, S.4    Yang, Z.5    Li, J.6
  • 43
    • 77949518018 scopus 로고    scopus 로고
    • MicroRNA-29a induces aberrant self-renewal capacity In hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia
    • Han Y.C., Park C.Y., Bhagat G., Zhang J., Wang Y., Fan J.B., et al. microRNA-29a induces aberrant self-renewal capacity In hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia. J. Exp. Med. 2010, 207:475-489.
    • (2010) J. Exp. Med. , vol.207 , pp. 475-489
    • Han, Y.C.1    Park, C.Y.2    Bhagat, G.3    Zhang, J.4    Wang, Y.5    Fan, J.B.6
  • 45
    • 84897427626 scopus 로고    scopus 로고
    • Attenuation of microRNA-126 expression that drives CD34+38- stem/progenitor cells in acute myeloid leukemia leads to tumor eradication
    • de Leeuw D.C., Denkers F., Olthof M., Rutten A., Pouwels W., et al. Attenuation of microRNA-126 expression that drives CD34+38- stem/progenitor cells in acute myeloid leukemia leads to tumor eradication. Cancer Res. 2014, 74:2094-2105.
    • (2014) Cancer Res. , vol.74 , pp. 2094-2105
    • de Leeuw, D.C.1    Denkers, F.2    Olthof, M.3    Rutten, A.4    Pouwels, W.5
  • 47
    • 84880571480 scopus 로고    scopus 로고
    • The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation
    • Song S.J., Ito K., Ala U., Kats L., Webster K., Sun S.M., et al. The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation. Cell Stem Cell 2013, 13:87-101.
    • (2013) Cell Stem Cell , vol.13 , pp. 87-101
    • Song, S.J.1    Ito, K.2    Ala, U.3    Kats, L.4    Webster, K.5    Sun, S.M.6
  • 48
    • 84884560027 scopus 로고    scopus 로고
    • MicroRNA-150 expression induces myeloid differentiation of human acute leukemia cells and normal hematopoietic progenitors
    • Morris V.A., Zhang A., Yang T., Stirewalt D.L., Ramamurthy R., Meshinchi S., et al. MicroRNA-150 expression induces myeloid differentiation of human acute leukemia cells and normal hematopoietic progenitors. PLoS One 2013, 8:e75815.
    • (2013) PLoS One , vol.8 , pp. e75815
    • Morris, V.A.1    Zhang, A.2    Yang, T.3    Stirewalt, D.L.4    Ramamurthy, R.5    Meshinchi, S.6
  • 49
    • 84878011791 scopus 로고    scopus 로고
    • Targeting of the signal transducer Smo links microRNA-326 to the oncogenic Hedgehog pathway in CD34+ CML stem/progenitor cells
    • Babashah S., Sadeghizadeh M., Hajifathali A., Tavirani M.R., Zomorod M.S., Ghadiani M., et al. Targeting of the signal transducer Smo links microRNA-326 to the oncogenic Hedgehog pathway in CD34+ CML stem/progenitor cells. Int. J. Cancer 2013, 133:579-589.
    • (2013) Int. J. Cancer , vol.133 , pp. 579-589
    • Babashah, S.1    Sadeghizadeh, M.2    Hajifathali, A.3    Tavirani, M.R.4    Zomorod, M.S.5    Ghadiani, M.6
  • 50
    • 84880223123 scopus 로고    scopus 로고
    • The role of microRNAs in breast cancer stem cells
    • Schwarzenbacher D., Balic M., Pichler M. The role of microRNAs in breast cancer stem cells. Int. J. Mol. Sci. 2013, 14:14712-14723.
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 14712-14723
    • Schwarzenbacher, D.1    Balic, M.2    Pichler, M.3
  • 51
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C., Hur M.H., Charafe-Jauffret E., Monville F., Dutcher J., Brown M., et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007, 1:555-567.
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3    Monville, F.4    Dutcher, J.5    Brown, M.6
  • 52
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos D., Hirsch H.A., Struhl K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 2009, 139:693-706.
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 53
    • 84879863078 scopus 로고    scopus 로고
    • Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state
    • Lim Y.Y., Wright J.A., Attema J.L., Gregory P.A., Bert A.G., Smith E., et al. Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state. J. Cell Sci. 2013, 126:2256-2266.
    • (2013) J. Cell Sci. , vol.126 , pp. 2256-2266
    • Lim, Y.Y.1    Wright, J.A.2    Attema, J.L.3    Gregory, P.A.4    Bert, A.G.5    Smith, E.6
  • 54
    • 84876272195 scopus 로고    scopus 로고
    • Let-7: a regulator of the ERα signaling pathway in human breast tumors and breast cancer stem cells
    • Sun X., Qin S., Fan C., Xu C., Du N., Ren H. Let-7: a regulator of the ERα signaling pathway in human breast tumors and breast cancer stem cells. Oncol. Rep. 2013, 29:2079-2087.
    • (2013) Oncol. Rep. , vol.29 , pp. 2079-2087
    • Sun, X.1    Qin, S.2    Fan, C.3    Xu, C.4    Du, N.5    Ren, H.6
  • 55
    • 84874324849 scopus 로고    scopus 로고
    • MiR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4
    • Okuda H., Xing F., Pandey P.R., Sharma S., Watabe M., Pai S.K., et al. miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4. Cancer Res. 2013, 73:1434-1444.
    • (2013) Cancer Res. , vol.73 , pp. 1434-1444
    • Okuda, H.1    Xing, F.2    Pandey, P.R.3    Sharma, S.4    Watabe, M.5    Pai, S.K.6
  • 56
    • 77954954098 scopus 로고    scopus 로고
    • Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells
    • Yu F., Deng H., Yao H., Liu Q., Su F., Song E. Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells. Oncogene 2010, 29:4194-4204.
    • (2010) Oncogene , vol.29 , pp. 4194-4204
    • Yu, F.1    Deng, H.2    Yao, H.3    Liu, Q.4    Su, F.5    Song, E.6
  • 57
    • 81255138201 scopus 로고    scopus 로고
    • Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5
    • Zhu Y., Yu F., Jiao Y., Feng J., Tang W., Yao H., Gong C., et al. Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5. Clin. Cancer Res. 2011, 17:7105-7115.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 7105-7115
    • Zhu, Y.1    Yu, F.2    Jiao, Y.3    Feng, J.4    Tang, W.5    Yao, H.6    Gong, C.7
  • 58
    • 84910593097 scopus 로고    scopus 로고
    • TGFbeta Induces 'BRCAness' and Sensitivity to PARP Inhibition in Breast Cancer by Regulating DNA Repair Genes
    • Liu L., Zhou W., Cheng C.T., Ren X., Somlo G., Fong M.Y. TGFbeta Induces 'BRCAness' and Sensitivity to PARP Inhibition in Breast Cancer by Regulating DNA Repair Genes. Mol. Cancer Res. 2014, 12:1597-1609.
    • (2014) Mol. Cancer Res. , vol.12 , pp. 1597-1609
    • Liu, L.1    Zhou, W.2    Cheng, C.T.3    Ren, X.4    Somlo, G.5    Fong, M.Y.6
  • 59
    • 84901241324 scopus 로고    scopus 로고
    • Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer
    • Li Q., Yao Y., Eades G., Liu Z., Zhang Y., Zhou Q. Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer. Oncogene 2014, 33:2589-2600.
    • (2014) Oncogene , vol.33 , pp. 2589-2600
    • Li, Q.1    Yao, Y.2    Eades, G.3    Liu, Z.4    Zhang, Y.5    Zhou, Q.6
  • 60
    • 84868131659 scopus 로고    scopus 로고
    • MiRNA expression profile of colon cancer stem cells compared to non-stem cells using the SW1116 cell line
    • Fang Y., Xiang J., Chen Z., Gu X., Li Z., Tang F., et al. miRNA expression profile of colon cancer stem cells compared to non-stem cells using the SW1116 cell line. Oncol. Rep. 2012, 28:2115-2124.
    • (2012) Oncol. Rep. , vol.28 , pp. 2115-2124
    • Fang, Y.1    Xiang, J.2    Chen, Z.3    Gu, X.4    Li, Z.5    Tang, F.6
  • 61
    • 80054924979 scopus 로고    scopus 로고
    • MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells
    • Bitarte N., Bandres E., Boni V., Zarate R., Rodriguez J., Gonzalez-Huarriz M., et al. MicroRNA-451 is involved in the self-renewal, tumorigenicity, and chemoresistance of colorectal cancer stem cells. Stem Cells 2011, 29:1661-1671.
    • (2011) Stem Cells , vol.29 , pp. 1661-1671
    • Bitarte, N.1    Bandres, E.2    Boni, V.3    Zarate, R.4    Rodriguez, J.5    Gonzalez-Huarriz, M.6
  • 62
    • 0037829660 scopus 로고    scopus 로고
    • Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
    • Pinto D., Gregorieff A., Begthel H., Clevers H. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 2003, 17:1709-1713.
    • (2003) Genes Dev. , vol.17 , pp. 1709-1713
    • Pinto, D.1    Gregorieff, A.2    Begthel, H.3    Clevers, H.4
  • 64
    • 84855389885 scopus 로고    scopus 로고
    • MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbetaR2) in colon cancer cells
    • Yu Y., Kanwar S.S., Patel B.B., Oh P.S., Nautiyal J., Sarkar F.H., Majumdar A.P. MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFbetaR2) in colon cancer cells. Carcinogenesis 2012, 33:68-76.
    • (2012) Carcinogenesis , vol.33 , pp. 68-76
    • Yu, Y.1    Kanwar, S.S.2    Patel, B.B.3    Oh, P.S.4    Nautiyal, J.5    Sarkar, F.H.6    Majumdar, A.P.7
  • 66
    • 84877263242 scopus 로고    scopus 로고
    • A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells
    • Bu P., Chen K.Y., Chen J.H., Wang L., Walters J., Shin Y.J., et al. A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. Cell Stem Cell 2013, 12:602-615.
    • (2013) Cell Stem Cell , vol.12 , pp. 602-615
    • Bu, P.1    Chen, K.Y.2    Chen, J.H.3    Wang, L.4    Walters, J.5    Shin, Y.J.6
  • 67
    • 34250306257 scopus 로고    scopus 로고
    • Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    • Ho M.M., Ng A.V., Lam S., Hung Y.J. Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res. 2007, 67:4827-4833.
    • (2007) Cancer Res. , vol.67 , pp. 4827-4833
    • Ho, M.M.1    Ng, A.V.2    Lam, S.3    Hung, Y.J.4
  • 68
    • 52449091004 scopus 로고    scopus 로고
    • Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties
    • Levina V., Marrangoni A.M., DeMarco R., Gorelik E., Lokshin A.E. Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties. PLoS One 2008, 3:e3077.
    • (2008) PLoS One , vol.3 , pp. e3077
    • Levina, V.1    Marrangoni, A.M.2    DeMarco, R.3    Gorelik, E.4    Lokshin, A.E.5
  • 69
    • 62549152644 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer
    • Jiang F., Qiu Q., Khanna A., Todd N.-W., Deepak J., Xing L., et al. Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer. Mol. Cancer Res. 2009, 7:330-338.
    • (2009) Mol. Cancer Res. , vol.7 , pp. 330-338
    • Jiang, F.1    Qiu, Q.2    Khanna, A.3    Todd, N.-W.4    Deepak, J.5    Xing, L.6
  • 71
    • 78649522166 scopus 로고    scopus 로고
    • Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties
    • Leung E.L., Fiscus R.R., Tung J.W., Tin V.P., Cheng L.C., Sihoe A.D., et al. Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties. PLoS One 2010, 5:e14062.
    • (2010) PLoS One , vol.5 , pp. e14062
    • Leung, E.L.1    Fiscus, R.R.2    Tung, J.W.3    Tin, V.P.4    Cheng, L.C.5    Sihoe, A.D.6
  • 72
    • 84863100269 scopus 로고    scopus 로고
    • Characterization of sphere-forming cells with stem-like properties from the small cell lung cancer cell line H446
    • Qiu X., Wang Z., Li Y., Miao Y., Ren Y., Luan Y. Characterization of sphere-forming cells with stem-like properties from the small cell lung cancer cell line H446. Cancer Lett. 2012, 323:161-170.
    • (2012) Cancer Lett. , vol.323 , pp. 161-170
    • Qiu, X.1    Wang, Z.2    Li, Y.3    Miao, Y.4    Ren, Y.5    Luan, Y.6
  • 73
    • 16544366235 scopus 로고    scopus 로고
    • CD44 in cancer progression: adhesion, migration and growth regulation
    • Marhaba R., Zoller M. CD44 in cancer progression: adhesion, migration and growth regulation. J. Mol. Histol. 2004, 35:211-231.
    • (2004) J. Mol. Histol. , vol.35 , pp. 211-231
    • Marhaba, R.1    Zoller, M.2
  • 74
    • 84896319764 scopus 로고    scopus 로고
    • Alveolar progenitor and stem cells in lung development, renewal and cancer
    • Desai T.J., Brownfield D.G., Krasnow M.A. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature 2014, 507:190-194.
    • (2014) Nature , vol.507 , pp. 190-194
    • Desai, T.J.1    Brownfield, D.G.2    Krasnow, M.A.3
  • 75
    • 84897042607 scopus 로고    scopus 로고
    • The microRNA miR-34a inhibits non-small cell lung cancer (NSCLC) growth and the CD44hi stem-like NSCLC cells
    • Shi Y., Liu C., Liu X., Tang D.G., Wang J. The microRNA miR-34a inhibits non-small cell lung cancer (NSCLC) growth and the CD44hi stem-like NSCLC cells. PLoS One 2014, 9:e90022.
    • (2014) PLoS One , vol.9 , pp. e90022
    • Shi, Y.1    Liu, C.2    Liu, X.3    Tang, D.G.4    Wang, J.5
  • 76
    • 55349148006 scopus 로고    scopus 로고
    • Identification of uPAR-positive chemoresistant cells in small cell lung cancer
    • Gutova M., Najbauer J., Gevorgyan A., Metz M.Z., Weng Y., Shih C.C. Identification of uPAR-positive chemoresistant cells in small cell lung cancer. PLoS One 2007, 2:e243.
    • (2007) PLoS One , vol.2 , pp. e243
    • Gutova, M.1    Najbauer, J.2    Gevorgyan, A.3    Metz, M.Z.4    Weng, Y.5    Shih, C.C.6
  • 77
    • 84872876364 scopus 로고    scopus 로고
    • MiR-27a regulates the self-renewal of the H446 small cell lung cancer cell line in vitro
    • Miao Y., Li J., Qiu X., Li Y., Wang Z., Luan Y. miR-27a regulates the self-renewal of the H446 small cell lung cancer cell line in vitro. Oncol. Rep. 2013, 29:161-168.
    • (2013) Oncol. Rep. , vol.29 , pp. 161-168
    • Miao, Y.1    Li, J.2    Qiu, X.3    Li, Y.4    Wang, Z.5    Luan, Y.6
  • 78
    • 84874807742 scopus 로고    scopus 로고
    • Cancer stem cells and therapeutic targets: an emerging field for cancer treatment
    • Vaz A.P., Ponnusamy M.P., Batra S.K. Cancer stem cells and therapeutic targets: an emerging field for cancer treatment. Drug Deliv. Transl. Res. 2013, 3:113-120.
    • (2013) Drug Deliv. Transl. Res. , vol.3 , pp. 113-120
    • Vaz, A.P.1    Ponnusamy, M.P.2    Batra, S.K.3
  • 79
    • 84921292963 scopus 로고    scopus 로고
    • MicroRNA-191, by promoting the EMT and increasing CSC-like properties, is involved in neoplastic and metastatic properties of transformed human bronchial epithelial cells
    • (Epub ahead of print)
    • Xu W., Ji J., Xu Y., Liu Y., Shi L., Liu Y. MicroRNA-191, by promoting the EMT and increasing CSC-like properties, is involved in neoplastic and metastatic properties of transformed human bronchial epithelial cells. Mol. Carcinog. 2014, (Epub ahead of print).
    • (2014) Mol. Carcinog.
    • Xu, W.1    Ji, J.2    Xu, Y.3    Liu, Y.4    Shi, L.5    Liu, Y.6
  • 80
    • 84905496411 scopus 로고    scopus 로고
    • MiR-326 is downstream of sonic hedgehog signaling and regulates the expression of Gli2 and smoothened
    • Jiang Z., Cushing L., Ai X., Lü J. miR-326 is downstream of sonic hedgehog signaling and regulates the expression of Gli2 and smoothened. Am. J. Respir. Cell Mol. Biol. 2014, 51:273-283.
    • (2014) Am. J. Respir. Cell Mol. Biol. , vol.51 , pp. 273-283
    • Jiang, Z.1    Cushing, L.2    Ai, X.3    Lü, J.4
  • 81
    • 84885083594 scopus 로고    scopus 로고
    • MicroRNA-218 inhibits glioma invasion, migration, proliferation, and cancer stem-like cell self-renewal by targeting the polycomb group gene Bmi1
    • Tu Y., Gao X., Li G., Fu H., Cui D., Liu H., et al. MicroRNA-218 inhibits glioma invasion, migration, proliferation, and cancer stem-like cell self-renewal by targeting the polycomb group gene Bmi1. Cancer Res. 2013, 73:6046-6055.
    • (2013) Cancer Res. , vol.73 , pp. 6046-6055
    • Tu, Y.1    Gao, X.2    Li, G.3    Fu, H.4    Cui, D.5    Liu, H.6
  • 83
    • 84883189850 scopus 로고    scopus 로고
    • MiR-128 coordinately targets polycomb repressor complexes in glioma stem cells
    • Peruzzi P., Bronisz A., Nowicki M.O., Wang Y., Ogawa D., Price R., et al. miR-128 coordinately targets polycomb repressor complexes in glioma stem cells. Neuro Oncol. 2013, 15:1212-1224.
    • (2013) Neuro Oncol. , vol.15 , pp. 1212-1224
    • Peruzzi, P.1    Bronisz, A.2    Nowicki, M.O.3    Wang, Y.4    Ogawa, D.5    Price, R.6
  • 84
    • 84876012922 scopus 로고    scopus 로고
    • MiR-134 regulates the proliferation and invasion of glioblastoma cells by reducing Nanog expression
    • Niu C.S., Yang Y., Cheng C.D. MiR-134 regulates the proliferation and invasion of glioblastoma cells by reducing Nanog expression. Int. J. Oncol. 2013, 42:1533-1540.
    • (2013) Int. J. Oncol. , vol.42 , pp. 1533-1540
    • Niu, C.S.1    Yang, Y.2    Cheng, C.D.3
  • 85
    • 84878421257 scopus 로고    scopus 로고
    • MicroRNA-153 is tumor suppressive in glioblastoma stem cells
    • Zhao S., Deng Y., Liu Y., Chen X., Yang G., Mu Y., et al. MicroRNA-153 is tumor suppressive in glioblastoma stem cells. Mol. Biol. Rep. 2013, 40:2789-2798.
    • (2013) Mol. Biol. Rep. , vol.40 , pp. 2789-2798
    • Zhao, S.1    Deng, Y.2    Liu, Y.3    Chen, X.4    Yang, G.5    Mu, Y.6
  • 86
    • 84872580192 scopus 로고    scopus 로고
    • Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype
    • Ying Z., Li Y., Wu J., Zhu X., Yang Y., Tian H., et al. Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype. Cancer Res. 2013, 73:990-999.
    • (2013) Cancer Res. , vol.73 , pp. 990-999
    • Ying, Z.1    Li, Y.2    Wu, J.3    Zhu, X.4    Yang, Y.5    Tian, H.6
  • 87
    • 79751473114 scopus 로고    scopus 로고
    • The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
    • Liu C., Kelnar K., Liu B., Chen X., Calhoun-Davis T., Li H., et al. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat. Med. 2011, 17:211-215.
    • (2011) Nat. Med. , vol.17 , pp. 211-215
    • Liu, C.1    Kelnar, K.2    Liu, B.3    Chen, X.4    Calhoun-Davis, T.5    Li, H.6
  • 88
    • 84874609641 scopus 로고    scopus 로고
    • Wild-type p53 suppresses the epithelial-mesenchymal transition and stemness in PC-3 prostate cancer cells by modulating miR-145
    • Ren D., Wang M., Guo W., Zhao X., Tu X., Huang S., et al. Wild-type p53 suppresses the epithelial-mesenchymal transition and stemness in PC-3 prostate cancer cells by modulating miR-145. Int. J. Oncol. 2013, 42:1473-1481.
    • (2013) Int. J. Oncol. , vol.42 , pp. 1473-1481
    • Ren, D.1    Wang, M.2    Guo, W.3    Zhao, X.4    Tu, X.5    Huang, S.6
  • 89
    • 38349064711 scopus 로고    scopus 로고
    • MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1
    • Tay Y.M., Tam W.L., Ang Y.S., Gaughwin P.M., Yang H., Wang W., et al. MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells 2008, 26:17-29.
    • (2008) Stem Cells , vol.26 , pp. 17-29
    • Tay, Y.M.1    Tam, W.L.2    Ang, Y.S.3    Gaughwin, P.M.4    Yang, H.5    Wang, W.6
  • 90
    • 84896469723 scopus 로고    scopus 로고
    • Aberrant microRNA Expression Likely Controls RAS Oncogene Activation During Malignant Transformation of Human Prostate Epithelial and Stem Cells by Arsenic
    • Ngalame N.N., Tokar E.J., Person R.J., Xu Y., Waalkes M.P. Aberrant microRNA Expression Likely Controls RAS Oncogene Activation During Malignant Transformation of Human Prostate Epithelial and Stem Cells by Arsenic. Toxicol. Sci. 2014, 138:268-277.
    • (2014) Toxicol. Sci. , vol.138 , pp. 268-277
    • Ngalame, N.N.1    Tokar, E.J.2    Person, R.J.3    Xu, Y.4    Waalkes, M.P.5
  • 91
    • 79952121979 scopus 로고    scopus 로고
    • Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
    • Iliopoulos D., Hirsch H.A., Wang G., Struhl K. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:1397-1402.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 1397-1402
    • Iliopoulos, D.1    Hirsch, H.A.2    Wang, G.3    Struhl, K.4
  • 93
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani S.A., Guo W., Liao M.J., Eaton E.N., Ayyanan A., Zhou A.Y. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 94
    • 84879983245 scopus 로고    scopus 로고
    • Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
    • Chaffer C.L., Marjanovic N.D., Lee T., Bell G., Kleer C.G., Reinhardt F. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell 2013, 154:61-74.
    • (2013) Cell , vol.154 , pp. 61-74
    • Chaffer, C.L.1    Marjanovic, N.D.2    Lee, T.3    Bell, G.4    Kleer, C.G.5    Reinhardt, F.6
  • 95
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park S.M., Gaur A.B., Lengyel E., Peter M.E. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008, 22:894-907.
    • (2008) Genes Dev. , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 96
    • 84869212635 scopus 로고    scopus 로고
    • Loss of SNAIL regulated miR-128-2 on chromosome 3p22.3 targets multiple stem cell factors to promote transformation of mammary epithelial cells
    • Qian P., Banerjee A., Wu Z.S., Zhang X., Wang H., Pandey V. Loss of SNAIL regulated miR-128-2 on chromosome 3p22.3 targets multiple stem cell factors to promote transformation of mammary epithelial cells. Cancer Res. 2012, 72:6036-6050.
    • (2012) Cancer Res. , vol.72 , pp. 6036-6050
    • Qian, P.1    Banerjee, A.2    Wu, Z.S.3    Zhang, X.4    Wang, H.5    Pandey, V.6
  • 97
    • 84894224148 scopus 로고    scopus 로고
    • The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression
    • Liu Y., Sánchez-Tilló E., Lu X., Huang L., Clem B., Telang S. The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression. J. Biol. Chem. 2014, 14:4116-4125.
    • (2014) J. Biol. Chem. , vol.14 , pp. 4116-4125
    • Liu, Y.1    Sánchez-Tilló, E.2    Lu, X.3    Huang, L.4    Clem, B.5    Telang, S.6
  • 98
    • 84055184850 scopus 로고    scopus 로고
    • MiR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    • Siemens H., Jackstadt R., Hünten S., Kaller M., Menssen A., Götz U., et al. miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 2011, 10:4256-4271.
    • (2011) Cell Cycle , vol.10 , pp. 4256-4271
    • Siemens, H.1    Jackstadt, R.2    Hünten, S.3    Kaller, M.4    Menssen, A.5    Götz, U.6
  • 99
    • 84873638537 scopus 로고    scopus 로고
    • MiR-125b functions as a key mediator for snail-induced stem cell propagation and chemoresistance
    • Liu Z., Liu H., Desai S., Schmitt D.C., Zhou M., Khong H.T. miR-125b functions as a key mediator for snail-induced stem cell propagation and chemoresistance. J. Biol. Chem. 2013, 288:4334-4345.
    • (2013) J. Biol. Chem. , vol.288 , pp. 4334-4345
    • Liu, Z.1    Liu, H.2    Desai, S.3    Schmitt, D.C.4    Zhou, M.5    Khong, H.T.6
  • 100
    • 77953806998 scopus 로고    scopus 로고
    • TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214
    • Yin G., Chen R., Alvero A.B., Fu H.H., Holmberg J., Glackin C. TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214. Oncogene 2010, 29:3545-3553.
    • (2010) Oncogene , vol.29 , pp. 3545-3553
    • Yin, G.1    Chen, R.2    Alvero, A.B.3    Fu, H.H.4    Holmberg, J.5    Glackin, C.6
  • 101
    • 84880168463 scopus 로고    scopus 로고
    • NVP-LDE-225 (Erismodegib) inhibits epithelial-mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128
    • Nanta R., Kumar D., Meeker D., Rodova M., Van Veldhuizen P.J., Shankar S. NVP-LDE-225 (Erismodegib) inhibits epithelial-mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128. Oncogenesis 2013, 2:e42.
    • (2013) Oncogenesis , vol.2 , pp. e42
    • Nanta, R.1    Kumar, D.2    Meeker, D.3    Rodova, M.4    Van Veldhuizen, P.J.5    Shankar, S.6
  • 102
    • 84855830390 scopus 로고    scopus 로고
    • Snail promotes the cell-autonomous generation of Flk1(+) endothelial cells through the repression of the microRNA-200 family
    • Gill J.G., Langer E.M., Lindsley R.C., Cai M., Murphy T.L., Murphy K.M. Snail promotes the cell-autonomous generation of Flk1(+) endothelial cells through the repression of the microRNA-200 family. Stem Cells Dev. 2012, 21:167-176.
    • (2012) Stem Cells Dev. , vol.21 , pp. 167-176
    • Gill, J.G.1    Langer, E.M.2    Lindsley, R.C.3    Cai, M.4    Murphy, T.L.5    Murphy, K.M.6
  • 103
    • 84865973282 scopus 로고    scopus 로고
    • An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state
    • Polytarchou C., Iliopoulos D., Struhl K. An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:14470-14475.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 14470-14475
    • Polytarchou, C.1    Iliopoulos, D.2    Struhl, K.3
  • 104
    • 84881247532 scopus 로고    scopus 로고
    • What makes cancer stem cell markers different?
    • Karsten U., Goletz S. What makes cancer stem cell markers different?. Springerplus 2013, 2:301.
    • (2013) Springerplus , vol.2 , pp. 301
    • Karsten, U.1    Goletz, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.