An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 36, 2012, Pages 14470-14475

  Polytarchoua, Christos ^a,b   Iliopoulosa, Dimitrios ^a,b   Struhlc, Kevin ^b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cellular transformation; Transcriptional regulation; Zeb 1 repressors

Indexed keywords

BMI1 PROTEIN; HERMES ANTIGEN; KRUPPEL LIKE FACTOR 4; MEMBRANE PROTEIN; MICRORNA 107; MICRORNA 182; MICRORNA 200; PROTEIN SUZ12; PROTEIN ZEB1; PROTEIN ZEB2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER GROWTH; CANCER STEM CELL; CELL POPULATION; CHROMATIN; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INHIBITION KINETICS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SUBUNIT; PROTEIN TARGETING; PURIFICATION; TRANSCRIPTION REGULATION;

BREAST NEOPLASMS; CELL DIFFERENTIATION; CELL LINE, TUMOR; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HUMANS; MICRORNAS; NEOPLASTIC STEM CELLS; POLYCOMB-GROUP PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

EID: 84865973282     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1212811109     Document Type: Article

References (41)

1. Ailles LE, Weissman IL (2007) Cancer stem cells in solid tumors. Curr Opin Biotechnol 18:460-466. (Pubitemid 350116595)
2. Polyak K, Weinberg RA (2009) Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits. Nat Rev Cancer 9:265-273.
3. Grimshaw MJ, et al. (2008) Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells. Breast Cancer Res 10(3):R52.
4. Marotta LL, Polyak K (2009) Cancer stem cells: A model in the making. Curr Opin Genet Dev 19(1):44-50.
5. Rosen JM, Jordan CT (2009) The increasing complexity of the cancer stem cell paradigm. Science 324:1670-1673.
6. Shackleton M, Quintana E, Fearon ER, Morrison SJ (2009) Heterogeneity in cancer: Cancer stem cells versus clonal evolution. Cell 138:822-829.
7. Gotoh N (2009) Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells. Curr Stem Cell Res Ther 4(1):9-15.
8. Ben-Porath I, et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40:499-507. (Pubitemid 351601215)
9. Shimono Y, et al. (2009) Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 138:592-603.
10. Iliopoulos D, Hirsch HA, Struhl K (2009) An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139: 693-706.
11. Iliopoulos D, et al. (2010) Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell 39:761-772.
12. Iliopoulos D, Hirsch HA, Wang G, Struhl K (2011) Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci USA 108:1397-1402.
13. Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K (2009) Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 69:7507-7511.
14. Iliopoulos D, Hirsch HA, Struhl K (2011) Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res 71:3196-3201.
15. Korpal M, Lee ES, Hu G, Kang Y (2008) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 283:14910-14914.
16. Bracken CP, et al. (2008) A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res 68: 7846-7854.
17. Gregory PA, et al. (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10:593-601. (Pubitemid 351627379)
18. Burk U, et al. (2008) A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 9:582-589. (Pubitemid 351772923)
19. Park SM, Gaur AB, Lengyel E, Peter ME (2008) The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22:894-907. (Pubitemid 351482843)
20. Wellner U, et al. (2009) The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 11:1487-1495.
21. Korpal M, et al. (2011) Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med 17:1101-1108.
22. Howe EN, Cochrane DR, Richer JK (2011) Targets of miR-200c mediate suppression of cell motility and anoikis resistance. Breast Cancer Res 13(2):R45.
23. Eades G, et al. (2011) miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells. J Biol Chem 286:25992-26002.
24. Brabletz S, et al. (2011) The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J 30:770-782.
25. Hirsch HA, et al. (2010) A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell 17:348-361.
26. Bandi N, et al. (2009) miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. Cancer Res 69:5553-5559.
27. Datta J, et al. (2011) microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase CE. Oncogene, 10.1038/onc.2011.565.
28. Sachdeva M, et al. (2009) p53 represses c-Myc through induction of the tumor suppressor miR-145. Proc Natl Acad Sci USA 106:3207-3212.
29. Png KJ, et al. (2011) MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes Dev 25:226-231.
30. Tavazoie SF, et al. (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451:147-152.
31. Katada T, et al. (2009) microRNA expression profile in undifferentiated gastric cancer. Int J Oncol 34:537-542.
32. Rokavec M, Wu W, Luo J-L (2012) IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis. Mol Cell 45(1):1-13.
33. Lee TI, et al. (2006) Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125:301-313. (Pubitemid 44313811)
34. Boyer LA, et al. (2006) Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441:349-353. (Pubitemid 44050199)
35. Squazzo SL, et al. (2006) Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res 16:890-900. (Pubitemid 43992913)
36. Zhong X, et al. (2007) Identification of tumorigenic retinal stem-like cells in human solid retinoblastomas. Int J Cancer 121:2125-2131. (Pubitemid 47585590)
37. Hoenerhoff MJ, et al. (2009) BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases. Oncogene 28:3022-3032.
38. Bracken AP, Helin K (2009) Polycomb group proteins: Navigators of lineage pathways led astray in cancer. Nat Rev Cancer 9:773-784.
39. Soule HD, et al. (1990) Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res 50:6075-6086. (Pubitemid 20331424)
40. Aziz N, Cherwinski H, McMahon M (1999) Complementation of defective colony-stimulating factor 1 receptor signaling and mitogenesis by Raf and v-Src. Mol Cell Biol 19:1101-1115. (Pubitemid 29046853)
41. Iliopoulos D, Jaeger SA, Hirsch HA, Bulyk ML, Struhl K (2010) STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell 39:493- 506.