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Volumn 20, Issue 10, 2014, Pages 544-550

Channelopathies, painful neuropathy, and diabetes: Which way does the causal arrow point?

Author keywords

Diabetes mellitus; Diabetic neuropathy; NaV1.7; Painful neuropathy; Sodium channelopathy; cells

Indexed keywords

SODIUM CHANNEL NAV1.7; VOLTAGE GATED SODIUM CHANNEL; SCN9A PROTEIN, HUMAN;

EID: 84921998193     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2014.06.003     Document Type: Review
Times cited : (31)

References (81)
  • 1
    • 2542429732 scopus 로고    scopus 로고
    • Diabetic somatic neuropathies
    • Boulton A.J., et al. Diabetic somatic neuropathies. Diabetes Care 2004, 27:1458-1486.
    • (2004) Diabetes Care , vol.27 , pp. 1458-1486
    • Boulton, A.J.1
  • 2
    • 78651101592 scopus 로고    scopus 로고
    • Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments
    • Tesfaye S., et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care 2010, 33:2285-2293.
    • (2010) Diabetes Care , vol.33 , pp. 2285-2293
    • Tesfaye, S.1
  • 3
    • 84860818001 scopus 로고    scopus 로고
    • Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K
    • Abbott C.A., et al. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K. Diabetes Care 2011, 34:2220-2224.
    • (2011) Diabetes Care , vol.34 , pp. 2220-2224
    • Abbott, C.A.1
  • 4
    • 34447626982 scopus 로고    scopus 로고
    • Diabetic neuropathy differs in type 1 and type 2 diabetes
    • Sima A.A., Kamiya H. Diabetic neuropathy differs in type 1 and type 2 diabetes. Ann. N. Y. Acad. Sci. 2006, 1084:235-249.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1084 , pp. 235-249
    • Sima, A.A.1    Kamiya, H.2
  • 5
    • 84866332807 scopus 로고    scopus 로고
    • Diabetic neuropathy: one disease or two?
    • Callaghan B.C., et al. Diabetic neuropathy: one disease or two?. Curr. Opin. Neurol. 2012, 25:536-541.
    • (2012) Curr. Opin. Neurol. , vol.25 , pp. 536-541
    • Callaghan, B.C.1
  • 6
    • 84861111124 scopus 로고    scopus 로고
    • Diabetic neuropathy: clinical manifestations and current treatments
    • Callaghan B.C., et al. Diabetic neuropathy: clinical manifestations and current treatments. Lancet Neurol. 2012, 11:521-534.
    • (2012) Lancet Neurol. , vol.11 , pp. 521-534
    • Callaghan, B.C.1
  • 7
    • 33746441608 scopus 로고    scopus 로고
    • The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes
    • Davies M., et al. The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care 2006, 29:1518-1522.
    • (2006) Diabetes Care , vol.29 , pp. 1518-1522
    • Davies, M.1
  • 8
    • 84880134135 scopus 로고    scopus 로고
    • Painful and painless diabetic neuropathy: one disease or two?
    • Spallone V., Greco C. Painful and painless diabetic neuropathy: one disease or two?. Curr. Diab. Rep. 2013, 13:533-549.
    • (2013) Curr. Diab. Rep. , vol.13 , pp. 533-549
    • Spallone, V.1    Greco, C.2
  • 9
    • 67349187994 scopus 로고    scopus 로고
    • Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics
    • Van Acker K., et al. Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics. Diabetes Metab. 2009, 35:206-213.
    • (2009) Diabetes Metab. , vol.35 , pp. 206-213
    • Van Acker, K.1
  • 10
    • 84895832615 scopus 로고    scopus 로고
    • Global estimates of diabetes prevalence for 2013 and projections for 2035
    • Guariguata L., et al. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diab. Res. Clin. Pract. 2014, 103:137-149.
    • (2014) Diab. Res. Clin. Pract. , vol.103 , pp. 137-149
    • Guariguata, L.1
  • 11
    • 27344458828 scopus 로고    scopus 로고
    • Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep
    • Gore M., et al. Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep. J. Pain Symptom Manage. 2005, 30:374-385.
    • (2005) J. Pain Symptom Manage. , vol.30 , pp. 374-385
    • Gore, M.1
  • 12
    • 84873689387 scopus 로고    scopus 로고
    • Burden of illness associated with painful diabetic peripheral neuropathy among adults seeking treatment in the US: results from a retrospective chart review and cross-sectional survey
    • Sadosky A., et al. Burden of illness associated with painful diabetic peripheral neuropathy among adults seeking treatment in the US: results from a retrospective chart review and cross-sectional survey. Diabetes Metab. Syndr. Obes. 2013, 6:79-92.
    • (2013) Diabetes Metab. Syndr. Obes. , vol.6 , pp. 79-92
    • Sadosky, A.1
  • 13
    • 84900871166 scopus 로고    scopus 로고
    • Health status, function, productivity, and costs among individuals with idiopathic painful peripheral neuropathy with small fiber involvement in the United States: results from a retrospective chart review and cross-sectional survey
    • Schaefer C., et al. Health status, function, productivity, and costs among individuals with idiopathic painful peripheral neuropathy with small fiber involvement in the United States: results from a retrospective chart review and cross-sectional survey. J. Med. Econ. 2014, 17:394-407.
    • (2014) J. Med. Econ. , vol.17 , pp. 394-407
    • Schaefer, C.1
  • 14
    • 79955910729 scopus 로고    scopus 로고
    • Association between pain severity and health care resource use, health status, productivity and related costs in painful diabetic peripheral neuropathy patients
    • DiBonaventura M.D., et al. Association between pain severity and health care resource use, health status, productivity and related costs in painful diabetic peripheral neuropathy patients. Pain Med. 2011, 12:799-807.
    • (2011) Pain Med. , vol.12 , pp. 799-807
    • DiBonaventura, M.D.1
  • 15
    • 67649445910 scopus 로고    scopus 로고
    • Comorbidities, healthcare service utilization and costs for patients identified with painful DPN in a managed-care setting
    • Ritzwoller D.P., et al. Comorbidities, healthcare service utilization and costs for patients identified with painful DPN in a managed-care setting. Curr. Med. Res. Opin. 2009, 25:1319-1328.
    • (2009) Curr. Med. Res. Opin. , vol.25 , pp. 1319-1328
    • Ritzwoller, D.P.1
  • 16
    • 80053180821 scopus 로고    scopus 로고
    • A new definition of neuropathic pain
    • Jensen T.S., et al. A new definition of neuropathic pain. Pain 2011, 152:2204-2205.
    • (2011) Pain , vol.152 , pp. 2204-2205
    • Jensen, T.S.1
  • 17
    • 84891809070 scopus 로고    scopus 로고
    • Mechanisms and management of diabetic painful distal symmetrical polyneuropathy
    • Tesfaye S., et al. Mechanisms and management of diabetic painful distal symmetrical polyneuropathy. Diabetes Care 2013, 36:2456-2465.
    • (2013) Diabetes Care , vol.36 , pp. 2456-2465
    • Tesfaye, S.1
  • 18
    • 80053583780 scopus 로고    scopus 로고
    • Small fiber neuropathy: role in the diagnosis of diabetic sensorimotor polyneuropathy
    • Malik R., et al. Small fiber neuropathy: role in the diagnosis of diabetic sensorimotor polyneuropathy. Diabetes Metab. Res. Rev. 2011, 27:678-684.
    • (2011) Diabetes Metab. Res. Rev. , vol.27 , pp. 678-684
    • Malik, R.1
  • 19
    • 33746351504 scopus 로고    scopus 로고
    • The relationship among pain, sensory loss, and small nerve fibers in diabetes
    • Sorensen L., et al. The relationship among pain, sensory loss, and small nerve fibers in diabetes. Diabetes Care 2006, 29:883-887.
    • (2006) Diabetes Care , vol.29 , pp. 883-887
    • Sorensen, L.1
  • 20
    • 77958172304 scopus 로고    scopus 로고
    • Painful diabetic neuropathy is associated with greater autonomic dysfunction than painless diabetic neuropathy
    • Gandhi R.A., et al. Painful diabetic neuropathy is associated with greater autonomic dysfunction than painless diabetic neuropathy. Diabetes Care 2010, 33:1585-1590.
    • (2010) Diabetes Care , vol.33 , pp. 1585-1590
    • Gandhi, R.A.1
  • 21
    • 84860624551 scopus 로고    scopus 로고
    • Impaired glucose tolerance and metabolic syndrome in idiopathic neuropathy
    • Smith A.G. Impaired glucose tolerance and metabolic syndrome in idiopathic neuropathy. J. Peripher. Nerv. Syst. 2012, 17(Suppl. 2):15-21.
    • (2012) J. Peripher. Nerv. Syst. , vol.17 , pp. 15-21
    • Smith, A.G.1
  • 22
    • 0035856416 scopus 로고    scopus 로고
    • Epidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathy
    • Smith A.G., et al. Epidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathy. Neurology 2001, 57:1701-1704.
    • (2001) Neurology , vol.57 , pp. 1701-1704
    • Smith, A.G.1
  • 23
    • 38349063153 scopus 로고    scopus 로고
    • Impaired glucose tolerance and neuropathy
    • Smith A.G., Singleton J.R. Impaired glucose tolerance and neuropathy. Neurologist 2008, 14:23-29.
    • (2008) Neurologist , vol.14 , pp. 23-29
    • Smith, A.G.1    Singleton, J.R.2
  • 24
    • 84865609605 scopus 로고    scopus 로고
    • Prediabetic neuropathy: does it exist?
    • Papanas N., Ziegler D. Prediabetic neuropathy: does it exist?. Curr. Diab. Rep. 2012, 12:376-383.
    • (2012) Curr. Diab. Rep. , vol.12 , pp. 376-383
    • Papanas, N.1    Ziegler, D.2
  • 25
    • 0034728403 scopus 로고    scopus 로고
    • The neuron as a dynamic electrogenic machine: modulation of sodium-channel expression as a basis for functional plasticity in neurons
    • Waxman S.G. The neuron as a dynamic electrogenic machine: modulation of sodium-channel expression as a basis for functional plasticity in neurons. Philos. Trans. R. Soc. Lond. B 2000, 355:199-213.
    • (2000) Philos. Trans. R. Soc. Lond. B , vol.355 , pp. 199-213
    • Waxman, S.G.1
  • 26
    • 29844439240 scopus 로고    scopus 로고
    • International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels
    • Catterall W.A., et al. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol. Rev. 2005, 57:411-425.
    • (2005) Pharmacol. Rev. , vol.57 , pp. 411-425
    • Catterall, W.A.1
  • 27
    • 3142761823 scopus 로고    scopus 로고
    • Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat
    • Hong S., et al. Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat. J. Biol. Chem. 2004, 279:29341-29350.
    • (2004) J. Biol. Chem. , vol.279 , pp. 29341-29350
    • Hong, S.1
  • 28
    • 84863169877 scopus 로고    scopus 로고
    • Reduced conduction failure of the main axon of polymodal nociceptive C-fibres contributes to painful diabetic neuropathy in rats
    • Sun W., et al. Reduced conduction failure of the main axon of polymodal nociceptive C-fibres contributes to painful diabetic neuropathy in rats. Brain 2012, 135:359-375.
    • (2012) Brain , vol.135 , pp. 359-375
    • Sun, W.1
  • 29
    • 84878927045 scopus 로고    scopus 로고
    • Increases in inflammatory mediators in DRG implicate in the pathogenesis of painful neuropathy in type 2 diabetes
    • Galloway C., Chattopadhyay M. Increases in inflammatory mediators in DRG implicate in the pathogenesis of painful neuropathy in type 2 diabetes. Cytokine 2013, 63:1-5.
    • (2013) Cytokine , vol.63 , pp. 1-5
    • Galloway, C.1    Chattopadhyay, M.2
  • 30
    • 0036894050 scopus 로고    scopus 로고
    • Changes of sodium channel expression in experimental painful diabetic neuropathy
    • Craner M.J., et al. Changes of sodium channel expression in experimental painful diabetic neuropathy. Ann. Neurol. 2002, 52:786-792.
    • (2002) Ann. Neurol. , vol.52 , pp. 786-792
    • Craner, M.J.1
  • 31
    • 0032400799 scopus 로고    scopus 로고
    • Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel
    • Cummins T.R., et al. Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel. J. Neurosci. 1998, 18:9607-9619.
    • (1998) J. Neurosci. , vol.18 , pp. 9607-9619
    • Cummins, T.R.1
  • 32
    • 33845893561 scopus 로고    scopus 로고
    • Neurobiology: a channel sets the gain on pain
    • Waxman S.G. Neurobiology: a channel sets the gain on pain. Nature 2006, 444:831-832.
    • (2006) Nature , vol.444 , pp. 831-832
    • Waxman, S.G.1
  • 33
    • 84871443483 scopus 로고    scopus 로고
    • The Na(V)1.7 sodium channel: from molecule to man
    • Dib-Hajj S.D., et al. The Na(V)1.7 sodium channel: from molecule to man. Nat. Rev. Neurosci. 2013, 14:49-62.
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 49-62
    • Dib-Hajj, S.D.1
  • 34
    • 84858739003 scopus 로고    scopus 로고
    • Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy
    • Chattopadhyay M., et al. Reduction of voltage gated sodium channel protein in DRG by vector mediated miRNA reduces pain in rats with painful diabetic neuropathy. Mol. Pain 2012, 8:17.
    • (2012) Mol. Pain , vol.8 , pp. 17
    • Chattopadhyay, M.1
  • 35
    • 80051545144 scopus 로고    scopus 로고
    • Vector-mediated release of GABA attenuates pain-related behaviors and reduces Na(V)1.7 in DRG neurons
    • Chattopadhyay M., et al. Vector-mediated release of GABA attenuates pain-related behaviors and reduces Na(V)1.7 in DRG neurons. Eur. J. Pain 2011, 15:913-920.
    • (2011) Eur. J. Pain , vol.15 , pp. 913-920
    • Chattopadhyay, M.1
  • 36
    • 84872042301 scopus 로고    scopus 로고
    • Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons
    • Zhang J.L., et al. Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons. Brain Res. 2013, 1493:13-18.
    • (2013) Brain Res. , vol.1493 , pp. 13-18
    • Zhang, J.L.1
  • 37
    • 84862020461 scopus 로고    scopus 로고
    • Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
    • Bierhaus A., et al. Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nat. Med. 2012, 18:926-933.
    • (2012) Nat. Med. , vol.18 , pp. 926-933
    • Bierhaus, A.1
  • 38
    • 84875970622 scopus 로고    scopus 로고
    • Antinociceptive activities of lidocaine and the nav1.8 blocker a803467 in diabetic rats
    • Mert T., Gunes Y. Antinociceptive activities of lidocaine and the nav1.8 blocker a803467 in diabetic rats. J. Am. Assoc. Lab. Anim. Sci. 2012, 51:579-585.
    • (2012) J. Am. Assoc. Lab. Anim. Sci. , vol.51 , pp. 579-585
    • Mert, T.1    Gunes, Y.2
  • 39
    • 0034900781 scopus 로고    scopus 로고
    • Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons
    • Renganathan M., et al. Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons. J. Neurophysiol. 2001, 86:629-640.
    • (2001) J. Neurophysiol. , vol.86 , pp. 629-640
    • Renganathan, M.1
  • 40
    • 33846974357 scopus 로고    scopus 로고
    • Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons
    • Rush A.M., et al. Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. J. Physiol. 2007, 579:1-14.
    • (2007) J. Physiol. , vol.579 , pp. 1-14
    • Rush, A.M.1
  • 41
    • 58149232445 scopus 로고    scopus 로고
    • Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas
    • Black J.A., et al. Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas. Ann. Neurol. 2008, 64:644-653.
    • (2008) Ann. Neurol. , vol.64 , pp. 644-653
    • Black, J.A.1
  • 42
    • 23444443202 scopus 로고    scopus 로고
    • Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons
    • Dib-Hajj S.D., et al. Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons. Brain 2005, 128:1847-1854.
    • (2005) Brain , vol.128 , pp. 1847-1854
    • Dib-Hajj, S.D.1
  • 43
    • 33847168937 scopus 로고    scopus 로고
    • SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes
    • Fertleman C.R., et al. SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron 2006, 52:767-774.
    • (2006) Neuron , vol.52 , pp. 767-774
    • Fertleman, C.R.1
  • 44
    • 33845901486 scopus 로고    scopus 로고
    • An SCN9A channelopathy causes congenital inability to experience pain
    • Cox J.J., et al. An SCN9A channelopathy causes congenital inability to experience pain. Nature 2006, 444:894-898.
    • (2006) Nature , vol.444 , pp. 894-898
    • Cox, J.J.1
  • 45
    • 84856143604 scopus 로고    scopus 로고
    • Gain of function Nanu1.7 mutations in idiopathic small fiber neuropathy
    • Faber C.G., et al. Gain of function Nanu1.7 mutations in idiopathic small fiber neuropathy. Ann. Neurol. 2012, 71:26-39.
    • (2012) Ann. Neurol. , vol.71 , pp. 26-39
    • Faber, C.G.1
  • 46
    • 84869795443 scopus 로고    scopus 로고
    • Gain-of-function Nav1.8 mutations in painful neuropathy
    • Faber C.G., et al. Gain-of-function Nav1.8 mutations in painful neuropathy. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:19444-19449.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 19444-19449
    • Faber, C.G.1
  • 47
    • 84901436064 scopus 로고    scopus 로고
    • Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathy
    • Huang J., et al. Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathy. Brain 2014, 137:1627-1642.
    • (2014) Brain , vol.137 , pp. 1627-1642
    • Huang, J.1
  • 48
    • 84907274301 scopus 로고    scopus 로고
    • Recent advances in the molecular genetics of type 2 diabetes mellitus
    • Brunetti A., et al. Recent advances in the molecular genetics of type 2 diabetes mellitus. World J. Diabetes 2014, 5:128-140.
    • (2014) World J. Diabetes , vol.5 , pp. 128-140
    • Brunetti, A.1
  • 49
    • 44649198581 scopus 로고    scopus 로고
    • The molecular genetics of type 1 diabetes: new genes and emerging mechanisms
    • Ounissi-Benkalha H., Polychronakos C. The molecular genetics of type 1 diabetes: new genes and emerging mechanisms. Trends Mol. Med. 2008, 14:268-275.
    • (2008) Trends Mol. Med. , vol.14 , pp. 268-275
    • Ounissi-Benkalha, H.1    Polychronakos, C.2
  • 50
    • 84873670723 scopus 로고    scopus 로고
    • Regulation of insulin secretion in human pancreatic islets
    • Rorsman P., Braun M. Regulation of insulin secretion in human pancreatic islets. Annu. Rev. Physiol. 2013, 75:155-179.
    • (2013) Annu. Rev. Physiol. , vol.75 , pp. 155-179
    • Rorsman, P.1    Braun, M.2
  • 51
    • 84882693811 scopus 로고    scopus 로고
    • Differential effect of D623N variant and wild-type Na(v)1.7 sodium channels on resting potential and interspike membrane potential of dorsal root ganglion neurons
    • Ahn H.S., et al. Differential effect of D623N variant and wild-type Na(v)1.7 sodium channels on resting potential and interspike membrane potential of dorsal root ganglion neurons. Brain Res. 2013, 1529:165-177.
    • (2013) Brain Res. , vol.1529 , pp. 165-177
    • Ahn, H.S.1
  • 52
    • 84863622829 scopus 로고    scopus 로고
    • Nav1.7-related small fiber neuropathy: impaired slow-inactivation and DRG neuron hyperexcitability
    • Han C., et al. Nav1.7-related small fiber neuropathy: impaired slow-inactivation and DRG neuron hyperexcitability. Neurology 2012, 78:1635-1643.
    • (2012) Neurology , vol.78 , pp. 1635-1643
    • Han, C.1
  • 53
    • 84866147238 scopus 로고    scopus 로고
    • Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy
    • Han C., et al. Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy. Brain 2012, 135:2613-2628.
    • (2012) Brain , vol.135 , pp. 2613-2628
    • Han, C.1
  • 54
    • 33744454923 scopus 로고    scopus 로고
    • A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons
    • Rush A.M., et al. A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:8245-8250.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 8245-8250
    • Rush, A.M.1
  • 55
    • 48249083049 scopus 로고    scopus 로고
    • Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion
    • Braun M., et al. Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion. Diabetes 2008, 57:1618-1628.
    • (2008) Diabetes , vol.57 , pp. 1618-1628
    • Braun, M.1
  • 56
    • 57349170894 scopus 로고    scopus 로고
    • Channel regulation of glucose sensing in the pancreatic beta-cell
    • Hiriart M., Aguilar-Bryan L. Channel regulation of glucose sensing in the pancreatic beta-cell. Am. J. Physiol. Endocrinol. Metab. 2008, 295:E1298-E1306.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295 , pp. E1298-E1306
    • Hiriart, M.1    Aguilar-Bryan, L.2
  • 57
    • 84876250129 scopus 로고    scopus 로고
    • Ion channels and regulation of insulin secretion in human beta-cells: a computational systems analysis
    • Fridlyand L.E., et al. Ion channels and regulation of insulin secretion in human beta-cells: a computational systems analysis. Islets 2013, 5:1-15.
    • (2013) Islets , vol.5 , pp. 1-15
    • Fridlyand, L.E.1
  • 58
    • 33645808245 scopus 로고    scopus 로고
    • Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells
    • Vignali S., et al. Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells. J. Physiol. 2006, 572:691-706.
    • (2006) J. Physiol. , vol.572 , pp. 691-706
    • Vignali, S.1
  • 59
    • 61849121436 scopus 로고    scopus 로고
    • Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion
    • Ernst S.J., et al. Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion. Endocrinology 2009, 150:1132-1139.
    • (2009) Endocrinology , vol.150 , pp. 1132-1139
    • Ernst, S.J.1
  • 60
    • 39749147110 scopus 로고    scopus 로고
    • Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes
    • Muoio D.M., Newgard C.B. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat. Rev. Mol. Cell Biol. 2008, 9:193-205.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 193-205
    • Muoio, D.M.1    Newgard, C.B.2
  • 61
  • 62
    • 61749086774 scopus 로고    scopus 로고
    • Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes
    • Girard C.A., et al. Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J. Clin. Invest. 2009, 119:80-90.
    • (2009) J. Clin. Invest. , vol.119 , pp. 80-90
    • Girard, C.A.1
  • 63
    • 77954840889 scopus 로고    scopus 로고
    • Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin
    • Clark R.H., et al. Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin. Science 2010, 329:458-461.
    • (2010) Science , vol.329 , pp. 458-461
    • Clark, R.H.1
  • 64
    • 0016284890 scopus 로고
    • Membrane potential of beta-cells in pancreatic islets
    • Meissner H.P., Schmelz H. Membrane potential of beta-cells in pancreatic islets. Pflugers Arch. 1974, 351:195-206.
    • (1974) Pflugers Arch. , vol.351 , pp. 195-206
    • Meissner, H.P.1    Schmelz, H.2
  • 65
    • 0023880410 scopus 로고
    • Na+ currents in cultured mouse pancreatic B-cells
    • Plant T.D. Na+ currents in cultured mouse pancreatic B-cells. Pflugers Arch. 1988, 411:429-435.
    • (1988) Pflugers Arch. , vol.411 , pp. 429-435
    • Plant, T.D.1
  • 66
    • 82455205940 scopus 로고    scopus 로고
    • Electrophysiology of pancreatic beta-cells in intact mouse islets of Langerhans
    • Rorsman P., et al. Electrophysiology of pancreatic beta-cells in intact mouse islets of Langerhans. Prog. Biophys. Mol. Biol. 2011, 107:224-235.
    • (2011) Prog. Biophys. Mol. Biol. , vol.107 , pp. 224-235
    • Rorsman, P.1
  • 67
    • 0025337490 scopus 로고
    • Sodium channels contribute to action potential generation in canine and human pancreatic islet B cells
    • Pressel D.M., Misler S. Sodium channels contribute to action potential generation in canine and human pancreatic islet B cells. J. Membr. Biol. 1990, 116:273-280.
    • (1990) J. Membr. Biol. , vol.116 , pp. 273-280
    • Pressel, D.M.1    Misler, S.2
  • 68
    • 0029417209 scopus 로고
    • Voltage-dependent Na+ and Ca2+ currents in human pancreatic islet beta-cells: evidence for roles in the generation of action potentials and insulin secretion
    • Barnett D.W., et al. Voltage-dependent Na+ and Ca2+ currents in human pancreatic islet beta-cells: evidence for roles in the generation of action potentials and insulin secretion. Pflugers Arch. 1995, 431:272-282.
    • (1995) Pflugers Arch. , vol.431 , pp. 272-282
    • Barnett, D.W.1
  • 69
    • 35348964085 scopus 로고    scopus 로고
    • The electrophysiology of the beta-cell based on single transmembrane protein characteristics
    • Meyer-Hermann M.E. The electrophysiology of the beta-cell based on single transmembrane protein characteristics. Biophys. J. 2007, 93:2952-2968.
    • (2007) Biophys. J. , vol.93 , pp. 2952-2968
    • Meyer-Hermann, M.E.1
  • 70
    • 0014867061 scopus 로고
    • The in vitro inhibition of insulin secretion by diphenylhydantoin
    • Kizer J.S., et al. The in vitro inhibition of insulin secretion by diphenylhydantoin. J. Clin. Invest. 1970, 49:1942-1948.
    • (1970) J. Clin. Invest. , vol.49 , pp. 1942-1948
    • Kizer, J.S.1
  • 71
    • 0016908323 scopus 로고
    • Studies on the hyperglycemic effect of diphenylhydantoin in normal golden hamsters
    • Tamburrano S., et al. Studies on the hyperglycemic effect of diphenylhydantoin in normal golden hamsters. Horm. Metab. Res. 1976, (Suppl. 6):74-79.
    • (1976) Horm. Metab. Res. , pp. 74-79
    • Tamburrano, S.1
  • 72
    • 0029826344 scopus 로고    scopus 로고
    • Phenytoin-induced hyperglycaemia may confound rat cerebroprotection models
    • Qi H., Newman G.C. Phenytoin-induced hyperglycaemia may confound rat cerebroprotection models. Clin. Exp. Pharmacol. Physiol. 1996, 23:893-897.
    • (1996) Clin. Exp. Pharmacol. Physiol. , vol.23 , pp. 893-897
    • Qi, H.1    Newman, G.C.2
  • 73
    • 0019800101 scopus 로고
    • Phenytoin-induced hyperglycemia
    • Carter B.L., et al. Phenytoin-induced hyperglycemia. Am. J. Hosp. Pharm. 1981, 38:1508-1512.
    • (1981) Am. J. Hosp. Pharm. , vol.38 , pp. 1508-1512
    • Carter, B.L.1
  • 74
    • 0013952238 scopus 로고
    • Diphenylhydantoin intoxication associated with hyperglycemia
    • Klein J.P. Diphenylhydantoin intoxication associated with hyperglycemia. J. Pediatr. 1966, 69:463-465.
    • (1966) J. Pediatr. , vol.69 , pp. 463-465
    • Klein, J.P.1
  • 75
    • 0014670247 scopus 로고
    • Hyperglycemia with relative hypoinsulinemia in diphenylhydantoin toxicity
    • Peters B.H., Samaan N.A. Hyperglycemia with relative hypoinsulinemia in diphenylhydantoin toxicity. N. Engl. J. Med. 1969, 281:91-92.
    • (1969) N. Engl. J. Med. , vol.281 , pp. 91-92
    • Peters, B.H.1    Samaan, N.A.2
  • 76
    • 0015105905 scopus 로고
    • Hyperglycaemia due to phenytoin toxicity
    • Treasure T., Toseland P.A. Hyperglycaemia due to phenytoin toxicity. Arch. Dis. Child. 1971, 46:563-564.
    • (1971) Arch. Dis. Child. , vol.46 , pp. 563-564
    • Treasure, T.1    Toseland, P.A.2
  • 77
    • 0018873002 scopus 로고
    • The effect of long-term diphenylhydantoin therapy on glucose tolerance and insulin secretion: a controlled trial
    • Perry-Keene D.A., et al. The effect of long-term diphenylhydantoin therapy on glucose tolerance and insulin secretion: a controlled trial. Clin. Endocrinol. 1980, 12:575-580.
    • (1980) Clin. Endocrinol. , vol.12 , pp. 575-580
    • Perry-Keene, D.A.1
  • 78
    • 0020079154 scopus 로고
    • Carbamazepine-induced hyperglycemia in hyponatremic rats
    • Tannhauser M., et al. Carbamazepine-induced hyperglycemia in hyponatremic rats. Pharmacology 1982, 24:123-125.
    • (1982) Pharmacology , vol.24 , pp. 123-125
    • Tannhauser, M.1
  • 79
    • 84873408163 scopus 로고    scopus 로고
    • Neuropathy-associated Nav1.7 variant I228M impairs integrity of dorsal root ganglion neuron axons
    • Persson A.K., et al. Neuropathy-associated Nav1.7 variant I228M impairs integrity of dorsal root ganglion neuron axons. Ann. Neurol. 2013, 73:140-145.
    • (2013) Ann. Neurol. , vol.73 , pp. 140-145
    • Persson, A.K.1
  • 80
    • 84889075974 scopus 로고    scopus 로고
    • Sodium channels contribute to degeneration of dorsal root ganglion neurites induced by mitochondrial dysfunction in an in vitro model of axonal injury
    • Persson A.K., et al. Sodium channels contribute to degeneration of dorsal root ganglion neurites induced by mitochondrial dysfunction in an in vitro model of axonal injury. J. Neurosci. 2013, 33:19250-19261.
    • (2013) J. Neurosci. , vol.33 , pp. 19250-19261
    • Persson, A.K.1
  • 81
    • 84886617294 scopus 로고
    • Probability of conduction deficit as related to fiber length in random-distribution models of peripheral neuropathies
    • Waxman S.G., et al. Probability of conduction deficit as related to fiber length in random-distribution models of peripheral neuropathies. J. Neurol. Sci. 1976, 29:39-53.
    • (1976) J. Neurol. Sci. , vol.29 , pp. 39-53
    • Waxman, S.G.1


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