Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons

Brain Research

Volumn 1493, Issue , 2013, Pages 13-18

  Zhang, Jun Long ^a,b   Yang, Jan Ping ^b   Zhang, Ji Ru ^a   Li, Rui Qin ^a   Wang, Jing ^a   Jan, Jin Jin ^a   Zhuang, Qing ^a  

^a Soochow University   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Dorsal root ganglion; Gabapentin; Nav1.7; p ERK1 2; Painful diabetic neuropathy

Indexed keywords

GABAPENTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SODIUM CHANNEL NAV1.7;

ALLODYNIA; ANALGESIA; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; DIABETIC NEUROPATHY; DRUG EFFICACY; HYPERALGESIA; IMMUNOREACTIVITY; MALE; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL GANGLION; UPREGULATION; WESTERN BLOTTING;

AMINES; ANALGESICS; ANIMALS; CYCLOHEXANECARBOXYLIC ACIDS; DIABETIC NEUROPATHIES; DISEASE MODELS, ANIMAL; GAMMA-AMINOBUTYRIC ACID; GANGLIA, SPINAL; HYPERALGESIA; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; NOCICEPTORS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84872042301     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.11.032     Document Type: Article

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