Differential effect of D623N variant and wild-type Nav1.7 sodium channels on resting potential and interspike membrane potential of dorsal root ganglion neurons

Brain Research

Volumn 1529, Issue , 2013, Pages 165-177

  Ahn, Hye Sook ^a,b   Vasylyev, Dmytro V ^a,b   Estacion, Mark ^a,b   MacAla, Lawrence J ^a,b   Shah, Palak ^a,b   Faber, Catharina G ^c   Merkies, Ingemar S J ^c,d   Dib Hajj, Sulayman D ^a,b   Waxman, Stephen G ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d Infection and Immunology   (Netherlands)

Author keywords

Dorsal root ganglia; Hodgkin Huxley; Hyperexcitability; NaV1.7; Small fiber neuropathy; Sodium channel

Indexed keywords

SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; ASPARAGINE; ASPARTIC ACID; GREEN FLUORESCENT PROTEIN; SCN9A PROTEIN, HUMAN; SODIUM CHANNEL NAV1.7; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; HYPERPOLARIZATION; MEMBRANE POTENTIAL; MEMBRANE STEADY POTENTIAL; NERVE CELL; NERVE CELL EXCITABILITY; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL GANGLION; VOLTAGE CLAMP; WILD TYPE; ANIMAL; BIOLOGICAL MODEL; BIOPHYSICS; CELL CULTURE; COMPUTER SIMULATION; CYTOLOGY; DRUG EFFECTS; ELECTROSTIMULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MUTATION; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ASPARAGINE; ASPARTIC ACID; BIOPHYSICS; CELLS, CULTURED; COMPUTER SIMULATION; ELECTRIC STIMULATION; GANGLIA, SPINAL; GREEN FLUORESCENT PROTEINS; HUMANS; MEMBRANE POTENTIALS; MODELS, NEUROLOGICAL; MUTATION; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; TETRODOTOXIN; TRANSFECTION;

EID: 84882693811     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.07.005     Document Type: Article

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