6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression

Chemico-Biological Interactions

Volumn 228, Issue , 2015, Pages 69-78

  Han, Min Ae ^a   Woo, Seon Min ^a   Min, Kyoung Jin ^a   Kim, Shin ^a   Park, Jong Wook ^a   Kim, Dong Eun ^a   Kim, Sang Hyun ^b   Choi, Yung Hyun ^c   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

^c Dong Eui University   (South Korea)

Author keywords

6 Shogaol; Apoptosis; c FLIP(L); ROS; TRAIL

Indexed keywords

(6) GINGEROL; CYTOCHROME C; FLICE INHIBITORY PROTEIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; RHODAMINE 123; SHOGAOL; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; ANTINEOPLASTIC AGENT; CATECHOL DERIVATIVE; CFLAR PROTEIN, HUMAN; TNFSF10 PROTEIN, HUMAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CARCINOMA CELL LINE; CARCINOMA CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG SENSITIZATION; GINGER; GLIOMA CELL LINE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OLIGOMERIZATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN SECRETION; RENAL CELL CARCINOMA CELL LINE; ANIMAL; CARCINOMA, RENAL CELL; CELL PROLIFERATION; CHEMISTRY; DEFICIENCY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; GENETICS; ISOLATION AND PURIFICATION; KIDNEY NEOPLASMS; METABOLISM; PATHOLOGY; SECRETION (PROCESS); STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ZINGIBER OFFICINALE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, RENAL CELL; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CATECHOLS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KIDNEY NEOPLASMS; MICE; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 84921996881     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.01.020     Document Type: Article

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