Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L)

Cell Death and Disease

Volumn 5, Issue 2, 2014, Pages

  Min, K J ^a   Seo, B R ^a   Bae, Y C ^b   Yoo, Y H ^c   Kwon, T K ^a  

^a Keimyung University   (South Korea)

^b Kyungpook National University   (South Korea)

^c Dong A University College of Medicine   (South Korea)

Author keywords

Akt; c FLIP; Mcl 1; ROS; thioridazine; TRAIL

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; FLICE INHIBITORY PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; THIORIDAZINE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; GLIOMA; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; KIDNEY CELL CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANTIOXIDANTS; ANTIPSYCHOTIC AGENTS; APOPTOSIS; BRAIN NEOPLASMS; BREAST NEOPLASMS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; KIDNEY NEOPLASMS; MICE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; OXIDATIVE STRESS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIORIDAZINE; TIME FACTORS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSFECTION;

EID: 84896748716     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.35     Document Type: Article

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