Licochalcone A induces apoptosis in malignant pleural mesothelioma through downregulation of Sp1 and subsequent activation of mitochondria-related apoptotic pathway

International Journal of Oncology

Volumn 46, Issue 3, 2015, Pages 1385-1392

  Kim, Ka Hwi ^a   Yoon, Goo ^a   Cho, Jung Jae ^a   Cho, Jin Hyoung ^b   Cho, Young Sik ^c   Chae, Jung Il ^b   Shim, Jung Hyun ^a  

^a Mokpo National University   (South Korea)

^b Chonbuk National University   (South Korea)

^c Keimyung University   (South Korea)

Author keywords

Apoptosis; Licochalcone A; Malignant pleural mesothelioma; Mitochondria; Specificity protein 1

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; CASPASE 3; CYCLIN D1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LICOCHALCONE A; LIPOCORTIN 5; PROTEIN BAX; PROTEIN BCL XL; PROTEIN MCL 1; SURVIVIN; TRANSCRIPTION FACTOR SP1; APOPTOSIS REGULATORY PROTEIN; CHALCONE DERIVATIVE; SP1 PROTEIN, HUMAN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL GROWTH; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ANALYSIS; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MITOCHONDRIAL MEMBRANE POTENTIAL; MTS ASSAY; PLEURA MESOTHELIOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CELL CULTURE; CELL PROLIFERATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; MESOTHELIOMA; METABOLISM; MITOCHONDRION; PATHOLOGY; PLEURA TUMOR; SIGNAL TRANSDUCTION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CHALCONES; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MESOTHELIOMA; MITOCHONDRIA; PLEURAL NEOPLASMS; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR;

EID: 84921929826     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2015.2839     Document Type: Article

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