PLK1 inhibition down-regulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster

Journal of Biological Chemistry

Volumn 290, Issue 5, 2015, Pages 3033-3044

  Dimri, Manjari ^a   Cho, Joon Ho ^a   Kang, Mingu ^a   Dimri, Goberdhan P ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASES; PROTEINS; RNA; STEM CELLS; TUMORS;

BREAST CANCER CELLS; CANCER STEM CELLS; GENE SILENCING; OVER-EXPRESSION; POLO-LIKE KINASE 1; POLYCOMB GROUP PROTEINS; SENESCENCE INDUCTION; TRANSCRIPTIONAL ACTIVITY;

C (PROGRAMMING LANGUAGE);

4 (8 CYCLOPENTYL 7 ETHYL 5,6,7,8 TETRAHYDRO 5 METHYL 6 OXO 2 PTERIDINYLAMINO) 3 METHOXY N (1 METHYL 4 PIPERIDINYL)BENZAMIDE; BMI1 PROTEIN; MICRORNA; MICRORNA 141; MICRORNA 200C; POLO LIKE KINASE 1; POLYCOMB GROUP PROTEIN; BMI1 PROTEIN, HUMAN; CELL CYCLE PROTEIN; MIRN141 MICRORNA, HUMAN; MIRN200 MICRORNA, HUMAN; ONCOPROTEIN; POLO-LIKE KINASE 1; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE;

3' UNTRANSLATED REGION; ARTICLE; BREAST CANCER CELL LINE; CANCER CELL LINE; CANCER INHIBITION; CANCER STEM CELL; CELL AGING; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; HUMAN; HUMAN CELL; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; TRANSCRIPTION REGULATION; UBIQUITINATION; UPREGULATION; WESTERN BLOTTING; FEMALE; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL LINE, TUMOR; FEMALE; HUMANS; MICRORNAS; POLYCOMB REPRESSIVE COMPLEX 1; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84921922123     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.615179     Document Type: Article

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