Carotenoids are Effective Inhibitors of in vitro Hemolysis of Human Erythrocytes, as Determined by a Practical and Optimized Cellular Antioxidant Assay

Journal of Food Science

Volumn 79, Issue 9, 2014, Pages H1841-H1847

  Chisté, Renan C ^a,b   Freitas, Marisa ^b   Mercadante, Adriana Z ^a   Fernandes, Eduarda ^b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

AAPH; Antioxidant capacity; Erythroprotective effect; Response surface methodology; Structure activity relationship

Indexed keywords

6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID; ANTIOXIDANT; ASCORBIC ACID; CAROTENOID; CHROMAN DERIVATIVE; PERHYDROXYL RADICAL; PEROXIDE; QUERCETIN; XANTHOPHYLL;

CELL PROTECTION; DRUG EFFECTS; ERYTHROCYTE; HEMOLYSIS; HUMAN; PHYSIOLOGY;

ANTIOXIDANTS; ASCORBIC ACID; CAROTENOIDS; CHROMANS; CYTOPROTECTION; ERYTHROCYTES; HEMOLYSIS; HUMANS; LUTEIN; PEROXIDES; QUERCETIN;

EID: 84921910359     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/1750-3841.12580     Document Type: Article

References (26)

1. Banerjee A, Kunwar A, Mishra B, Priyadarsini KI. 2008. Concentration dependent antioxidant/pro-oxidant activity of curcumin Studies from AAPH induced hemolysis of RBCs. Chem-Biol Interact 174(2):134-9.
2. Chisté RC, Mercadante AZ, Gomes A, Fernandes E, Lima JLFD, Bragagnolo N. 2011. In vitro scavenging capacity of annatto seed extracts against reactive oxygen and nitrogen species. Food Chem 127(2):419-26.
3. Chisté RC, Freitas M, Mercadante AZ, Fernandes E. 2012. The potential of extracts of Caryocar villosum pulp to scavenge reactive oxygen and nitrogen species. Food Chem 135(3):1740-9.
4. Chisté RC, Freitas M, Mercadante AZ, Fernandes E. 2014. Carotenoids inhibit lipid peroxidation and hemoglobin oxidation, but not the depletion of glutathione induced by ROS in human erythrocytes. Life Sci 99(1-2):52-60.
5. Di Mascio P, Kaiser S, Sies H. 1989. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 274(2):532-8.
6. El-Agamey A, Lowe GM, McGarvey DJ, Mortensen A, Phillip DM, Truscott TG, Young AJ. 2004. Carotenoid radical chemistry and antioxidant/pro-oxidant properties. Arch Biochem Biophys 430(1):37-48.
7. Guo JJ, Hu CH. 2010. Mechanism of chain termination in lipid peroxidation by carotenes: a theoretical study. J Phys Chem B 114(50):16948-58.
8. Jomova K, Kysel O, Madden JC, Morris H, Enoch SJ, Budzak S, Young AJ, Cronin MTD, Mazur M, Valko M. 2009. Electron transfer from all-trans- β-carotene to the t-butyl peroxyl radical at low oxygen pressure (an EPR spectroscopy and computational study). Chem Phys Lett 478(4-6):266-70.
9. Kiko T, Nakagawa K, Tsuduki T, Suzuki T, Arai H, Miyazawa T. 2012. Significance of lutein in red blood cells of Alzheimer's disease patients. J Alzheimers Dis 28(3):593-600.
10. Ko FN, Hsiao G, Kuo YH. 1997. Protection of oxidative hemolysis by demethyldiisoeugenol in normal and β-thalassemic red blood cells. Free Radical Bio Med 22(1-2):215-22.
11. Kok TMCM, de Waard P, Wilms LC, van Breda SGJ. 2010. Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: the value of genomics biomarkers in molecular epidemiology. Mol Nutr Food Res 54(2):208-17.
12. Lian FZ, Hu KQ, Russell RM, Wang XD. 2006. β-Cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non-small-cell lung cancer cells and up-regulates retinoic acid receptor β expression. Int J Cancer 119(9):2084-9.
13. Lorenzo Y, Azqueta A, Luna L, Bonilla F, Dominguez G, Collins AR. 2009. The carotenoid b-cryptoxanthin stimulates the repair of DNA oxidation damage in addition to acting as an antioxidant in human cells. Carcinogenesis 30(2):308-14.
14. Magalhães AS, Silva BM, Pereira JA, Andrade PB, Valentao P, Carvalho M. 2009. Protective effect of quince (Cydonia oblonga Miller) fruit against oxidative hemolysis of human erythrocytes. Food Chem Toxicol 47(6):1372-7.
15. Miyazawa T, Suzuki T, Yasuda K, Fujimoto K, Meguro K, Sasaki H. 1992. Accumulation of phospholipid hydroperoxides in red blood cell membranes in Alzheimer disease. In: Yagi, K., Kondo, M., Niki, E., Yoshikawa, T., editors. Oxygen Radicals. Amsterdam: Elsevier Science Publishing. p 327-30.
16. Müller L, Theile K, Böhm V. 2010. In vitro antioxidant activity of tocopherols and tocotrienols and comparison of vitamin E concentration and lipophilic antioxidant capacity in human plasma. Mol Nutr Food Res 54(5):731-42.
17. Naguib YMA. 2000. Antioxidant activities of astaxanthin and related carotenoids. J Agric Food Chem 48(4):1150-4.
18. Nakagawa K, Kiko T, Hatade K, Asai A, Kimura F, Sookwong P, Tsuduki T, Arai H, Miyazawa T. 2008. Development of a high-performance liquid chromatography-based assay for carotenoids in human red blood cells: application to clinical studies. Anal Biochem 381(1):129-34.
19. Niki E. 1990. Free-radical initiators as source of water-soluble or lipid-soluble peroxyl radicals. Method Enzymol 186:100-108.
20. Niki E. 1991. Action of ascorbic-acid as a scavenger of active and stable oxygen radicals. Am J Clin Nutr 54(6):S1119-24.
21. Ou BX, Hampsch-Woodill M, Prior RL. 2001. Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem 49(10):4619-26.
22. Rodrigues E, Mariutti LRB, Chiste RC, Mercadante AZ. 2012. Development of a novel micro-assay for evaluation of peroxyl radical scavenger capacity: Application to carotenoids and structure-activity relationship. Food Chem 135(3):2103-111.
23. Sato Y, Kamo S, Takahashi T, Suzuki Y. 1995. Mechanism of free radical-induced hemolysis of human erythrocytes-hemolysis by water-soluble radical initiator. Biochemistry 34(28):8940-9.
24. Silva BM, Santos RP, Mendes LS, de Pinho PG, Valentao P, Andrade PB, Pereira JA, Carvalho M. 2011. Dracaena draco L. fruit: phytochemical and antioxidant activity assessment. Food Res Int 44(7):2182-9.
25. Sundaram S, Anjum S, Dwivedi P, Rai GK. 2011. Antioxidant activity and protective effect of banana peel against oxidative hemolysis of human erythrocyte at different stages of ripening. Appl Biochem Biotech 164(7):1192-206.
26. Zou CG, Agar NS, Jones GL. 2001. Oxidative insult to human red blood cells induced by free radical initiator AAPH and its inhibition by a commercial antioxidant mixture. Life Sci 69(1):75-86.