Ameliorative effects of 5-hydroxymethyl-2-furfural (5-HMF) from Schisandra chinensis on alcoholic liver oxidative injury in mice

International Journal of Molecular Sciences

Volumn 16, Issue 2, 2015, Pages 2446-2457

  Li, Wei ^a,b   Qu, Xin Nan ^b   Han, Ye ^b   Zheng, Si Wen ^a   Wang, Jia ^a,b   Wang, Ying Ping ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

^b JILIN AGRICULTURAL UNIVERSITY   (China)

Author keywords

5 HMF; Alcohol liver injury; Oxidative stress; Schisandra chinensis

Indexed keywords

5 HYDROXYMETHYLFURFURAL; CATALASE; GLUTATHIONE PEROXIDASE; INTERLEUKIN 1BETA; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; 5-HYDROXYMETHYLFURFURAL; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; FURFURAL; PROTECTIVE AGENT; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CELL ADHESION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ISOLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER FATTY DEGENERATION; LIVER INJURY; MALE; MOUSE; NONHUMAN; ORGAN WEIGHT; OXIDATIVE STRESS; PROTEIN EXPRESSION; SCHISANDRA CHINENSIS; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMISTRY; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; LIVER DISEASES, ALCOHOLIC; METABOLISM; PATHOLOGY; SCHISANDRA;

ANIMALIA; MUS; SCHISANDRA CHINENSIS;

ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; CATALASE; CHOLESTEROL; CHOLESTEROL, LDL; FURALDEHYDE; GLUTATHIONE PEROXIDASE; INTERLEUKIN-1BETA; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; MALONDIALDEHYDE; MICE; MICE, INBRED ICR; OXIDATIVE STRESS; PROTECTIVE AGENTS; SCHISANDRA; SUPEROXIDE DISMUTASE; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84921864350     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16022446     Document Type: Article

References (37)

1. Gramenzi, A.; Caputo, F.; Biselli, M.; Kuria, F.; Loggi, E.; Andreone, P.; Bernardi, M. Review article: Alcoholic liver disease—pathophysiological aspects and risk factors. Aliment. Pharmacol. Ther. 2006, 24, 1151-1161.
2. Tang, C.C.; Huang, H.P.; Lee, Y.J.; Tang, Y.H.; Wang, C.J. Hepatoprotective effect of mulberry water extracts on ethanol-induced liver injury via anti-inflammation and inhibition of lipogenesis in c57bl/6j mice. Food Chem. Toxicol. 2013, 62, 786-796.
3. Neuman, M.G.; French, S.W.; Casey, C.A.; Kharbanda, K.K.; Nanau, R.M.; Rasineni, K.; McVicker, B.L.; Kong, V.; Donohue, T.M., Jr. Changes in the pathogenesis of alcohol-induced liver disease preclinical studies. Exp. Mol. Pathol. 2013, 95, 376-384.
4. Zeng, T.; Guo, F.F.; Zhang, C.L.; Zhao, S.; Dou, D.D.; Gao, X.C.; Xie, K.Q. The anti-fatty liver effects of garlic oil on acute ethanol-exposed mice. Chem.-Biol. Interact. 2008, 176, 234-242.
5. Mesias-Garcia, M.; Guerra-Hernandez, E.; Garcia-Villanova, B. Determination of furan precursors and some thermal damage markers in baby foods: Ascorbic acid, dehydroascorbic acid, hydroxymethylfurfural and furfural. J. Agric. Food Chem. 2010, 58, 6027-6032.
6. Zirbes, L.; Nguyen, B.K.; de Graaf, D.C.; de Meulenaer, B.; Reybroeck, W.; Haubruge, E.; Saegerman, C. Hydroxymethylfurfural: A possible emergent cause of honey bee mortality? J. Agric. Food Chem. 2013, 61, 11865-11870.
7. Yamada, P.; Nemoto, M.; Shigemori, H.; Yokota, S.; Isoda, H. Isolation of 5-(hydroxymethyl)furfural from lycium chinense and its inhibitory effect on the chemical mediator release by basophilic cells. Planta Med. 2011, 77, 434-440.
8. Cao, G.; Cai, H.; Cai, B.; Tu, S. Effect of 5-hydroxymethylfurfural derived from processed cornus officinalis on the prevention of high glucose-induced oxidative stress in human umbilical vein endothelial cells and its mechanism. Food Chem. 2013, 140, 273-279.
9. Won, T.H.; Liao, L.; Kang, S.S.; Shin, J. Simultaneous analysis of furfural metabolites from rehmanniae radix preparata by hplc-dad-esi-ms. Food Chem. 2014, 142, 107-113.
10. Liu, Z.; Chao, Z.; Liu, Y.; Song, Z.; Lu, A. Maillard reaction involved in the steaming process of the root of polygonum multiflorum. Planta Med. 2009, 75, 84-88.
11. Xu, Q.; Li, Y.H.; Lu, X.Y. Investigation on influencing factors of 5-hmf content in schisandra. J. Zhejiang Univ. Sci. B 2007, 8, 439-445.
12. Abraham, K.; Gurtler, R.; Berg, K.; Heinemeyer, G.; Lampen, A.; Appel, K.E. Toxicology and risk assessment of 5-hydroxymethylfurfural in food. Mol. Nutr. Food Res. 2011, 55, 667-678.
13. Capuano, E.; Fogliano, V. Acrylamide and 5-hydroxymethylfurfural (hmf): A review on metabolism, toxicity, occurrence in food and mitigation strategies. LWT Food Sci. Technol. 2011, 44, 793-810.
14. Truzzi, C.; Annibaldi, A.; Illuminati, S.; Finale, C.; Rossetti, M.; Scarponi, G. Determination of very low levels of 5-(hydroxymethyl)-2-furaldehyde (hmf) in natural honey: Comparison between the hplc technique and the spectrophotometric white method. J. Food Sci. 2012, 77, C784-C790.
15. Gidamis, A.B.; Chove, B.E.; Shayo, N.B.; Nnko, S.A.; Bangu, N.T. Quality evaluation of honey harvested from selected areas in tanzania with special emphasis on hydroxymethyl furfural (hmf) levels. Plant Foods Hum. Nutr. 2004, 59, 129-132.
16. Monakhova, Y.B.; Lachenmeier, D.W. The margin of exposure of 5-hydroxymethylfurfural (hmf) in alcoholic beverages. Environ. Health Toxicol. 2012, 27, e2012016.
17. Del Campo, G.; Berregi, I.; Caracena, R.; Zuriarrain, J. Quantitative determination of caffeine, formic acid, trigonelline and 5-(hydroxymethyl)furfural in soluble coffees by 1 h nmr spectrometry. Talanta 2010, 81, 367-371.
18. Zhao, L.; Chen, J.; Su, J.; Li, L.; Hu, S.; Li, B.; Zhang, X.; Xu, Z.; Chen, T. In vitro antioxidant and antiproliferative activities of 5-hydroxymethylfurfural. J. Agric. Food Chem. 2013, 61, 10604-10611.
19. Li, M.M.; Wu, L.Y.; Zhao, T.; Xiong, L.; Huang, X.; Liu, Z.H.; Fan, X.L.; Xiao, C.R.; Gao, Y.; Ma, Y.B, et al. The protective role of 5-hmf against hypoxic injury. Cell Stress Chaperones 2011, 16, 267-273.
20. Janzowski, C.; Glaab, V.; Samimi, E.; Schlatter, J.; Eisenbrand, G. 5-hydroxymethylfurfural: Assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione. Food Chem. Toxicol. 2000, 38, 801-809.
21. Powell, R.D.; Swet, J.H.; Kennedy, K.L.; Huynh, T.T.; McKillop, I.H.; Evans, S.L. Resveratrol attenuates hypoxic injury in a primary hepatocyte model of hemorrhagic shock and resuscitation. J. Trauma Acute Care Surg. 2014, 76, 409-417.
22. Ding, X.; Wang, M.Y.; Yao, Y.X.; Li, G.Y.; Cai, B.C. Protective effect of 5-hydroxymethylfurfural derived from processed fructus corni on human hepatocyte lo2 injured by hydrogen peroxide and its mechanism. J. Ethnopharmacol. 2010, 128, 373-376.
23. Hwang, I.S.; Kim, J.E.; Lee, Y.J.; Kwak, M.H.; Choi, Y.H.; Kang, B.C.; Hong, J.T.; Hwang, D.Y. Protective effects of gomisin a isolated from schisandra chinensis against ccl(4)-induced hepatic and renal injury. Int. J. Mol. Med. 2013, 31, 888-898.
24. Zeng, T.; Zhang, C.L.; Song, F.Y.; Zhao, X.L.; Yu, L.H.; Zhu, Z.P.; Xie, K.Q. The activation of ho-1/nrf-2 contributes to the protective effects of diallyl disulfide (dads) against ethanol-induced oxidative stress. Biochim. Biophys. Acta 2013, 1830, 4848-4859.
25. Ibrahim, M.; Hassan, W.; Meinerz, D.F.; Leite Gde, O.; Nogueira, C.W.; Rocha, J.B. Ethanol-induced oxidative stress: The role of binaphthyl diselenide as a potent antioxidant. Biol. Trace Elem. Res. 2012, 147, 309-314.
26. Liu, H.; Qi, X.; Cao, S.; Li, P. Protective effect of flavonoid extract from Chinese bayberry (myrica rubra sieb. Et zucc.) fruit on alcoholic liver oxidative injury in mice. J. Nat. Med. 2014, 68, 521-529.
27. Mantena, S.K.; King, A.L.; Andringa, K.K.; Landar, A.; Darley-Usmar, V.; Bailey, S.M. Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease. World J. Gastroenterol. 2007, 13, 4967-4973.
28. Parlesak, A.; Schafer, C.; Paulus, S.B.; Hammes, S.; Diedrich, J.P.; Bode, C. Phagocytosis and production of reactive oxygen species by peripheral blood phagocytes in patients with different stages of alcohol-induced liver disease: Effect of acute exposure to low ethanol concentrations. Alcohol. Clin. Exp. Res. 2003, 27, 503-508.
29. Kawaratani, H.; Tsujimoto, T.; Douhara, A.; Takaya, H.; Moriya, K.; Namisaki, T.; Noguchi, R.; Yoshiji, H.; Fujimoto, M.; Fukui, H. The effect of inflammatory cytokines in alcoholic liver disease. Mediat. Inflamm. 2013, 2013, 495156.
30. Orman, E.S.; Odena, G.; Bataller, R. Alcoholic liver disease: Pathogenesis, management, and novel targets for therapy. J. Gastroenterol. Hepatol. 2013, 28, 77-84.
31. Kim, H.K.; Choi, Y.W.; Lee, E.N.; Park, J.K.; Kim, S.G.; Park, D.J.; Kim, B.S.; Lim, Y.T.; Yoon, S. 5-hydroxymethylfurfural from black garlic extract prevents tnfalpha-induced monocytic cell adhesion to huvecs by suppression of vascular cell adhesion molecule-1 expression, reactive oxygen species generation and nf-kappab activation. Phytother. Res. 2011, 25, 965-974.
32. Brunt, E.M. Grading and staging the histopathological lesions of chronic hepatitis: The knodellhistology activity index and beyond. Hepatology 2000, 31, 241-246.
33. Clark, D.L. Handbook helps students improve writing skills. J. Am. Med. Rec. Assoc. 1985, 56, 42-45.
34. Mohandas, J.; Marshall, J.J.; Duggin, G.G.; Horvath, J.S.; Tiller, D.J. Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer. Cancer Res. 1984, 44, 5086-5091.
35. Beauchamp, C.; Fridovich, I. Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels. Anal. Biochem. 1971, 44, 276-287.
36. Draper, H.H.; Hadley, M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol. 1990, 186, 421-431.
37. Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.