Resveratrol attenuates hypoxic injury in a primary hepatocyte model of hemorrhagic shock and resuscitation

Journal of Trauma and Acute Care Surgery

Volumn 76, Issue 2, 2014, Pages 409-417

  Powell, Rebecca D ^a   Swet, Jacob H ^a   Kennedy, Kenneth L ^a   Huynh, Toan T ^a   McKillop, Iain H ^a   Evans, Susan L ^a  

^a CAROLINAS MEDICAL CENTER   (United States)

Author keywords

Hemorrhagic shock; mitochondria; oxidative stress; rats; resveratrol; sirtuin 1

Indexed keywords

ANIMALS; BLOTTING, WESTERN; CELL DEATH; CELL HYPOXIA; CELL SURVIVAL; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; MALE; MITOCHONDRIA, LIVER; NF-KAPPA B; OXIDATIVE STRESS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; RESUSCITATION; SHOCK, HEMORRHAGIC; SIRTUIN 1; STILBENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84894087243     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000096     Document Type: Article

References (37)

1. Whittaker B, Christiaans SC, Altice JL, Chen MK, Bartolucci AA, Morgan CJ, et al. Early coagulopathy is an independent predictor of mortality in children after severe trauma. Shock. 2013;39(5):421-426.
2. Lv KY, Yu XY, Bai YS, Zhu SH, Tang HT, Ben DF, et al. Role of inhibition of p38 mitogen-activated protein kinase in liver dysfunction after hemorrhagic shock and resuscitation. J Surg Res. 2012;178(2):827-832.
3. Sursal T, Stearns-Kurosawa DJ, Itagaki K, Oh SY, Sun S, Kurosawa S, et al. Plasma bacterial and mitochondrial DNA distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates. Shock. 2013;39(1):55-62.
4. Jarrar D, Wang P, Cioffi WG, Bland KI, Chaudry IH. Critical role of oxygen radicals in the initiation of hepatic depression after trauma hemorrhage. J Trauma. 2000;49(5):879-885.
5. Prasad K, Lee P. Role of oxyradicals in the pathophysiology of hemorrhagic shock. Int J Angiol. 2002;11:113-128.
6. Heckbert SR, Vedder NB, Hoffman W, Winn RK, Hudson LD, Jurkovich GJ, et al. Outcome after hemorrhagic shock in trauma patients. J Trauma. 1998;45(3):545-549.
7. Helling TS. The liver and hemorrhagic shock. J Am Coll Surg. 2005; 201(5):774-783.
8. Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I. Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys. 2010;501(1):79-90.
9. Kloster MM, Naderi EH, Haaland I, Gjertsen BT, Blomhoff HK, Naderi S. cAMP signalling inhibits p53 acetylation and apoptosis via HDAC and SIRT deacetylases. Int J Oncol. 2013;42(5):1815-1821.
10. Yang H, Zhang W, Pan H, Feldser HG, Lainez E, Miller C, et al. SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-kappaB activity. PloS One. 2012; 7(9):e46364.
11. Yang L, Zhang J, Yan C, Zhou J, Lin R, Lin Q, et al. SIRT1 regulates CD40 expression induced by TNF- via NF-JB pathway in endothelial cells. Cell Physiol Biochem. 2012;30(5):1287-1298.
12. Kawasaki T, Chaudry IH. The effects of estrogen on various organs: therapeutic approach for sepsis, trauma, and reperfusion injury. Part 2: liver, intestine, spleen, and kidney. J Anesth. 2012;26(6):892-899.
13. DhanasekaranA,Kotamraju S,Kalivendi SV,Matsunaga T, Shang T,Keszler A, et al. Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis. J Biol Chem. 2004;279(36):37575-37587.
14. Schauer RJ, Kalmuk S, Gerbes AL, Leiderer R, Meissner H, Schildberg FW, et al. Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation. World J Gastroenterol. 2004;10(6):864-870.
15. Yabe Y, Kobayashi N, Nishihashi T, Takahashi R, Nishikawa M, Takakura Y, et al. Prevention of neutrophil-mediated hepatic ischemia/reperfusion injury by superoxide dismutase and catalase derivatives. J Pharmacol Exp Ther. 2001;298(3):894-899.
16. Gedik E, Girgin S, Ozturk H, Obay BD, Ozturk H, Buyukbayram H. Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats. World J Gastroenterol. 2008;14(46): 7101-7106.
17. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5(6):493-506.
18. Ozkan OV, Yuzbasioglu MF, Ciralik H, Kurutas EB, Yonden Z, Aydin M, et al. Resveratrol, a natural antioxidant, attenuates intestinal ischemia/reperfusion injury in rats. Tohoku J Exp Med. 2009;218(3):251-258.
19. Zhang C, Lin G,Wan W, Li X, Zeng B, Yang B, et al. Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-kappaB signaling pathway. Int JMolMed. 2012;29(4): 557-563.
20. Jian B, Yang S, Chaudry IH, Raju R. Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating Sirt1. Mol Med. 2012;18:209-214.
21. Yu HP, Hwang TL, Hsieh PW, Lau YT. Role of estrogen receptordependent upregulation of P38 MAPK/heme oxygenase 1 in resveratrolmediated attenuation of intestinal injury after trauma-hemorrhage. Shock. 2011;35(5):517-523.
22. Montegudo AE, Palilonis MA, Moore CC, Huynh T, McKillop IH, Evans SL. Pyrrolidine dithiocarbamate improves mortality in a rat model of severe hemorrhage. J Surg Res. 2013;179(1):e149-55.
23. Sokolov E, Eheim AL, Ahrens WA, Walling TL, Swet JH, McMillan MT, et al. Lysophosphatidic acid receptor expression and function in human hepatocellular carcinoma. J Surg Res. 2013;180(1):104-113.
24. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol. 1976;13:29-83.
25. Hubbard WJ, Bland KI, Chaudry IH. The role of the mitochondrion in trauma and shock. Shock. 2004;22(5):395-402.
26. Shimahara Y, Ozawa K, Ida T, Ukikusa M, Tobe T. Four stages of mitochondrial deterioration in hemorrhagic shock. Res Exp Med (Berl). 1981;179(1):23-33.
27. Lin HC, Lai IR. Isolated mitochondria infusion mitigates ischemiareperfusion injury of the liver in rats: reply. Shock. 2013;39(6):543.
28. Yu HP, Hsu JC, Hwang TL, Yen CH, Lau YT. Resveratrol attenuates hepatic injury after trauma-hemorrhage via estrogen receptor-related pathway. Shock. 2008;30(3):324-328.
29. Bratslavsky G, Kogan BA, Matsumoto S, Aslan AR, Levin RM. Reperfusion injury of the rat bladder is worse than ischemia. J Urol. 2003; 170(5):2086-2090.
30. Czerny C, Theruvath TP, Maldonado EN, Lehnert M, Marzi I, Zhong Z, et al. C-Jun N-terminal kinase 2 promotes liver injury via the mitochondrial permeability transition after hemorrhage and resuscitation. HPB Surg. 2012;2012:641982.
31. Dewar D, Moore FA, Moore EE, Balogh Z. Postinjury multiple organ failure. Injury. 2009;40(9):912-918.
32. Eltzschig HK, Collard CD. Vascular ischaemia and reperfusion injury. Br Med Bull. 2004;70:71-86.
33. Yu HP, Yang SC, Lau YT, Hwang TL. Role of Akt-dependent up-regulation of hemeoxygenase-1 in resveratrol-mediated attenuation of hepatic injury after trauma hemorrhage. Surgery. 2010;148(1):103-109.
34. DioumEM, Chen R, AlexanderMS, Zhang Q, Hogg RT, Gerard RD, et al. Regulation of hypoxia-inducible factor 2alpha signaling by the stressresponsive deacetylase sirtuin 1. Science. 2009;324(5932):1289-1293.
35. Laemmle A, Lechleiter A, Roh V, Schwarz C, Portmann S, Furer C, et al. Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1alpha protein under hypoxic conditions. PloS One. 2012; 7(3):e33433.
36. Watroba M, Maslinska D, Maslinski S. Current overview of functions of FoxO proteins, with special regards to cellular homeostasis, cell response to stress, as well as inflammation and aging. Adv Med Sci. 2012;57(2):183-195.
37. Csiszar A, Labinskyy N, Pinto JT, Ballabh P, Zhang H, Losonczy G, et al. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol. 2009;297(1):H13-H20.