Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells

Biochemical Pharmacology

Volumn 93, Issue 3, 2015, Pages 332-342

  Wiggins, Helen L ^a   Wymant, Jennifer M ^a   Solfa, Francesca ^a   Hiscox, Stephen E ^a   Taylor, Kathryn M ^a   Westwell, Andrew D ^a   Jones, Arwyn T ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Breast cancer; Disulfiram; Fluozin 3; Lysosomes; Zinc

Indexed keywords

COPPER; DIETHYLDITHIOCARBAMIC ACID; DISULFIRAM; EPIDERMAL GROWTH FACTOR RECEPTOR 2; IONOPHORE; PYRITHIONE SODIUM; ZINC; CYTOTOXIN;

ARTICLE; AUTOPHAGY; BREAST CANCER; BREAST CANCER CELL LINE; CANCER CELL; CELL DEATH; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENDOSOME; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; LYSOSOME; PRIORITY JOURNAL; TARGET CELL; APOPTOSIS; BREAST NEOPLASMS; DOSE RESPONSE; DRUG EFFECTS; ENDOCYTOSIS; FEMALE; MCF 7 CELL LINE; METABOLISM; PHYSIOLOGY;

APOPTOSIS; BREAST NEOPLASMS; CYTOTOXINS; DISULFIRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCYTOSIS; FEMALE; HUMANS; LYSOSOMES; MCF-7 CELLS; ZINC;

EID: 84921841456     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.12.014     Document Type: Article

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